DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mthl10 and mthl4

DIOPT Version :9

Sequence 1:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_788394.1	Gene:	mthl4 / 36960	FlyBaseID:	FBgn0034219	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	172/550 - (31%)
Similarity:	287/550 - (52%)	Gaps:	54/550 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLCLVVFRLIPGIPFGTYVMAERDHYHTIDDPNVP-CNFYDTVNLTGHRLFPNGSYDYYGTIVPA 84
            :|..|:|.|:|.                 .:..:| |:|:|||:::....|.||||.|.|.::||
  Fly     4 LLIAVLFLLMPK-----------------SNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPA 51

  Fly    85 ELVGTYDYIHSSLTERIEVREHVRGCVCKFKSCLNICCPWRQVFNSEVDGCIIDHSDNRTWPDPP 149
            .|...|||...:...:.:|..|||||.|..:.|:..|||  |....:...|..|.|::......|
  Fly    52 HLTAEYDYKLLADDSKEKVASHVRGCACHLRPCIRFCCP--QYQKMQKSKCYGDMSEDELNKHDP 114

  Fly   150 MLNITFRNESTILVNMFTQFAIQS--FRP-CPKMFSLQPETNNWDDYLLFENGSMLRVDDKLLIR 211
            .:|:|..:.|.:..:......:||  .:| ||:|:.|..|... :::.||||||:||..||:.:.
  Fly   115 FVNVTLSDGSVVRRHFKEDLIVQSDLAKPGCPRMYFLNHELPG-NEFTLFENGSLLRHWDKVELS 178

  Fly   212 KNEFCMVPTYVNESDMFYTIHPANCDMQDDHS-TVKIINSYAMMFSIPFMMLTIAVYLLIPELRN 275
            |.|:|:  .:::..|....|.|..|.:..:|| |.|.:   |::.|:..::|||:|||.:.:|||
  Fly   179 KREYCV--QHLSFKDDSIRIAPHFCPLSSEHSRTWKTV---AIVISLICIILTISVYLYVEKLRN 238

  Fly   276 QHGKSLVCYLIGLSVGYSSLCY-VQLYQVDATGVTCKVFGYTAYFFFMGAYMWLSVISFDLWHNF 339
            .|||..:|||..|.:||..|.. |..|   ::|. |...|:..||..|.|:.|||||...|...|
  Fly   239 LHGKCFICYLASLFLGYFFLVLNVWKY---SSGF-CVTAGFLGYFSVMAAFFWLSVIGIHLRIKF 299

  Fly   340 R-GTRGINRFQEKKRFLFYSLYSWGIALVFLAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSNWA 403
            . .:..::|...:..|..|:||:|||.|:..|.||.|.|:.. ...|:|.:|.|..||:...:..
  Fly   300 SLASNCLHRLLPENPFRAYNLYAWGIPLIMTAITYTADQVVK-NEKLRPRVGVGKNCWIYTGDMT 363

  Fly   404 AMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKRFYRAWSNYRFG 468
            .|||||||:|.::..|.|||:::||.|:.:::.:..::..:.:.:.:..::           .|.
  Fly   364 VMIYFYGPMLLLIAFNIIMFVLSAIYIYNIKKNVKGLVHKQQTNQQINDQQ-----------MFA 417

  Fly   469 LFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLFVMKKKVKHLI----T 529
            :|||||::||::|..|::|:.:...:.|::...::|..|..||.:||:||::|..:..||    .
  Fly   418 IFLRLFILMGLSWSFEILSFLLTKQQAWARALMVADYFNWSQGTIIFVLFILKPSILKLIIAGGR 482

  Fly   530 NRCSSVRDGSNQRQSQYSTKTTS--SSVAN 557
            .........|..:.::|::..|:  .|:|:
  Fly   483 QNLPGSHHNSRSKAARYNSTHTACEGSIAD 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	61/182 (34%)
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	90/271 (33%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:284145	61/182 (34%)
mthl4	NP_788394.1	7tm_4	213..>385	CDD:304433	69/179 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.070