Protein Alignment mthl10 and mthl14

DIOPT Version :9

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_728509.1
• Gene: mthl14 / 318046
• FlyBaseID: FBgn0052476
• Length: 533
• Species: Drosophila melanogaster
• Alignment Length: 453
• Identity: 97/453 - (21%)
• Similarity: 183/453 - (40%)
• Gaps: 99/453 - (21%)

  Fly   116 SCLNICCPWRQVFNSEVDGCIIDHSDNRTWPDPPMLNITFRNESTILVNMFTQFAIQSFRP---- 176
            |.|..|||               |.:|        |||...|:|..:.:.    .:.||.|
  Fly   115 SRLRKCCP---------------HGEN--------LNIYRENQSDSMCDN----GLLSFEPTIIS 152

  Fly   177 ------CPKMFSLQPETNNWDDYLLFE--NGSMLRVDDK----LLIRKNEFCMVPTYVNESDMFY 229
                  |  :..|:.||..  ||.:..  |.|:| .|||    .:::.....::..:.|||   |
  Fly   153 AVLFDNC--IEDLEVETTL--DYDIGNPCNSSLL-YDDKDDVFFVLQDGSLLIIDKFGNES---Y 209

  Fly   230 TIHPANC----------------DMQDDHSTVKII-NSYAMMFSIPFMMLTIAVYLLIPELRNQH 277
            |:....|                .:::..:..|:: .:..|:.|:|.::|...:::.:..|||.|
  Fly   210 TVKEHYCLDIDKSGHLFAFTCVTQVEEQIAFAKVVFVAVLMLISMPCLLLVSYLHMTLRLLRNLH 274

  Fly   278 GKSLVCYLIGLSVGYSSLCYVQLYQVDATGVTCKVFGYTAYFFFMGAYMWLSVISF----DLWHN 338
            |.||....:.|:.||.....|.:|.:...|    ..||...|..:..:.|...|.|    ::|:.
  Fly   275 GLSLSLMSLCLASGYFVHSVVHIYGIPNQG----FIGYVIQFCILSYFFWYLCICFNVLLNVWYK 335

  Fly   339 FRGTRGINRFQEKKRFLFYSLYSWGIALVFLAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSNWA 403
            .......::......|..|:::::......:|.| ..:.|..:|:....|:.:.:.        .
  Fly   336 LPCCIQCSKSWATFNFACYAVFAFSGPATIVALT-VQKGLPGMPSYFLQGLTESIR--------D 391

  Fly   404 AMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEK---DKRFYRAWSNY 465
            :..||..|:..|:.   :.|::..|...|.|    ||.....:.||::..|   |::.|......
  Fly   392 SQRYFIPPVSTILF---LSFLLNIISFFGFQ----RISGYAKAEKNIQERKCLFDQQKYEDVKKD 449

  Fly   466 RFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLFVMKKKVKHLI 528
            ...:.| |.:||.::||.|:|:::.||:   |....:.|:.|.:||..:.::|::.::.:.:|
  Fly   450 AKCVSL-LGIIMVVSWLLEIITFYSGSN---SNYLILCDMVNGLQGVWVLLIFLVVRRRRTII 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	32/135 (24%)
		7tm_4	244..514	CDD:304433	62/277 (22%)
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	64/294 (22%)
		TM helix 1	241..266	CDD:320167	5/24 (21%)
		TM helix 2	275..297	CDD:320167	7/21 (33%)
		TM helix 3	306..331	CDD:320167	6/24 (25%)
		TM helix 4	349..369	CDD:320167	3/19 (16%)
		TM helix 5	389..418	CDD:320167	6/39 (15%)
		TM helix 6	445..472	CDD:320167	8/27 (30%)
		TM helix 7	477..502	CDD:320167	6/24 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462176
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840