Protein Alignment mthl10 and ADGRE2

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_054176753.1
• Gene: ADGRE2 / 30817
• HGNCID: 3337
• Length: 892
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 80/369 - (21%)
• Similarity: 141/369 - (38%)
• Gaps: 89/369 - (24%)

  Fly   229 YTIHPANCDMQDDHSTVKIINSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYS 293
            :.:..|:.|:|::...:.:|....:..|:..::|....:||...::|. ..||...|
Human   589 FAVLMAHYDVQEEDPVLTVITYMGLSVSLLCLLLAALTFLLCKAIQNT-STSLHLQL-------- 644

  Fly   294 SLC-----YVQLYQVDATG--VTCKVFGYTAYFFFMGAYMWLSVISFDLWHNFRGT-----RGIN 346
            |||     .:.|..:|.||  |.|.:...|.::.::....|:.:.:..|:...|..     ..||
Human   645 SLCLFLAHLLFLVAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYLFLTARNLTVVNYSSIN 709

  Fly   347 RFQEKKRFLFYSLYSWGIALVFLAFTYCAQ-QLTNLPANLKPGIGDGVYCWLDMSN---WAAMIY 407
            ||.:|..|    ...:|:..|.:|.:..:: .|...|:.          |||....   |.
Human   710 RFMKKLMF----PVGYGVPAVTVAISAASRPHLYGTPSR----------CWLQPEKGFIWG---- 756

  Fly   408 FYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENST-KNLRTEKDKRFYRAWSNYRFGLFL 471
            |.||:.||...|.::|::|.    .:.:.....:.||.|| :|.|.            ..|....
Human   757 FLGPVCAIFSVNLVLFLVTL----WILKNRLSSLNSEVSTLRNTRM------------LAFKATA 805

  Fly   472 RLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLFVMKKKVKHLITNRCSSVR 536
            :|| |:|.||...::.  ||  .....:.|:..:.|::||..||:::.:.
Human   806 QLF-ILGCTWCLGILQ--VG--PAARVMAYLFTIINSLQGVFIFLVYCLL--------------- 850

  Fly   537 DGSNQRQSQYSTKT-------TSSSVANLSLHEKPSVEKPLVIS 573
              |.|.:.||...:       |.|.:..||...|....||..::
Human   851 --SQQVREQYGKWSKGIRKLKTESEMHTLSSSAKADTSKPSTVN 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	1/6 (17%)
		7tmB3_Methuselah-like	242..533	CDD:410632	66/307 (21%)
		TM helix 1	244..269	CDD:410632	3/24 (13%)
		TM helix 2	278..300	CDD:410632	6/26 (23%)
		TM helix 3	311..338	CDD:410632	3/26 (12%)
		TM helix 4	354..374	CDD:410632	4/19 (21%)
		TM helix 5	401..430	CDD:410632	9/31 (29%)
		TM helix 6	446..489	CDD:410632	11/43 (26%)
		TM helix 7	497..522	CDD:410632	6/24 (25%)
ADGRE2	XP_054176753.1	EGF_CA	136..168	CDD:429571
		EGF_CA	188..>220	CDD:214542
		EGF_CA	232..263	CDD:429571
		EGF_CA	281..312	CDD:429571
		GPS	548..598	CDD:197639	1/8 (13%)
		7tmB2_EMR	602..864	CDD:320555	70/326 (21%)
		TM helix 1	604..629	CDD:320555	3/24 (13%)
		TM helix 2	638..660	CDD:320555	7/29 (24%)
		TM helix 3	669..696	CDD:320555	3/26 (12%)
		TM helix 4	713..733	CDD:320555	5/23 (22%)
		TM helix 5	750..773	CDD:320555	7/26 (27%)
		TM helix 6	797..822	CDD:320555	8/39 (21%)
		TM helix 7	826..851	CDD:320555	6/41 (15%)