Protein Alignment mthl10 and mthl12

DIOPT Version :9

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_731791.2
• Gene: mthl12 / 261599
• FlyBaseID: FBgn0045442
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 512
• Identity: 141/512 - (27%)
• Similarity: 236/512 - (46%)
• Gaps: 86/512 - (16%)

  Fly    56 CNFYDTVNLTGHRLFPNGSYDYYGTIVPAELVGTYDYIHSSLTERIEVR---EHVRGCVCKFKSC 117
            |.:.:|:|:: |....|.:|.|....:||.|.|.:||  ..|.:..:|.   .::|||:||.:.|
  Fly    27 CKYDETINIS-HFKRLNDAYIYEHFEIPANLTGEFDY--KELMDGSKVPTEFPNLRGCICKVRPC 88

  Fly   118 LNICCPWRQVF-NSEV-DGCIIDHSDNRTWPDPPMLNITFRNESTILVNMFTQF-------AIQS 173
            :.|||..:.:. |.|. ||  :.:....|..|..|.:|...:.:...:||..|:       ..:.
  Fly    89 IRICCARKNILSNGECSDG--VKNEIKLTMLDLTMQDILLTDPTLAELNMIPQYNSTELLILREQ 151

  Fly   174 FRPCPKMFSLQPETNNWDDYLLFENGSMLRVDDKLLIRKNEFCMVPTYVNESDMFYTIHPANCDM 238
            |:||.::.||:.     |:|.:.::||:|......::..:::|:.|.       .|:..|
  Fly   152 FQPCDEIVSLKR-----DEYTILKDGSILLHTSAEILSNDQYCLYPE-------IYSDFP----- 199

  Fly   239 QDDHSTVKIIN-----------SYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGY 292
                .|::|||           :...:.|:...:||:||||.:.:|||..||.|:|.|..:.:.|
  Fly   200 ----ETIRIINRRCYRNVMPGIAQLSVISVVGFILTLAVYLSVEKLRNLLGKCLICSLFSMFMEY 260

  Fly   293 S--SLCYVQLYQVDATGVTCKVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQEKKRFL 355
            .  ::.|.:|.|     ..|...||..|||.|.:|:|.||:||.||..|   ..:||.:.:.|||
  Fly   261 FIWTMDYFRLLQ-----SICSAAGYMKYFFSMSSYLWFSVVSFHLWELF---TSLNRHEPQYRFL 317

  Fly   356 FYSLYSWGIALVFLAFTYCAQQL-TNLPANLK--PGIGDGVYCWLDMSNWAAMIYFYG--PILAI 415
            .|:.:.|..|.:.....:...|: .|.|...:  |.:|   |....:.:|.:..:||.  ||:.:
  Fly   318 IYNTFVWCTAAIPTVVIFSMNQMWENDPGKSEWLPLVG---YFGCSVKDWNSSSWFYSHIPIVIL 379

  Fly   416 VVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGIT 480
            ...|.|||::|||.|..|::.: :..|..:.......|.:.:.|..        |:|||||||.:
  Fly   380 NSFNVIMFVLTAIYIWKVKKGV-KSFAQHDERNTTCLEFNVQTYIQ--------FVRLFLIMGAS 435

  Fly   481 WLTELISYFVGSDKGWSKLFY------ISDLANAMQGFLIFMLFVMKKKVKHLITNR 531
            ||.:.::.....    |.|..      ::...||..|.|||:|.::|.....:|..|
  Fly   436 WLLDQLTRLAED----SHLLLDTIVLNLTVYLNAAFGILIFVLLILKGSTFKMIMER 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	49/191 (26%)
		7tm_4	244..514	CDD:304433	85/293 (29%)
mthl12	NP_731791.2	Methuselah_N	27..209	CDD:284145	53/207 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449114
Domainoid	1	1.000	49	1.000	Domainoid score	I4416
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I5395
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111500at6656
OrthoFinder	1	1.000	-	-		FOG0003851
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR47154
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	7.000