DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl10 and Adgrf5

DIOPT Version :10

Sequence 1:NP_788446.2 Gene:mthl10 / 38057 FlyBaseID:FBgn0035132 Length:585 Species:Drosophila melanogaster
Sequence 2:XP_038938942.1 Gene:Adgrf5 / 245977 RGDID:621679 Length:1426 Species:Rattus norvegicus


Alignment Length:438 Identity:93/438 - (21%)
Similarity:167/438 - (38%) Gaps:98/438 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 FSLQPETNNWDDYLLFENGSMLRVDDKLLIRKNEFCMVPTYVNESDMFYTIHPANCDMQDDHSTV 245
            |||...|..||     .:|..:. ||....|...||.    .|....|..:  .:.|..|..|.:
  Rat  1036 FSLANNTGGWD-----SSGCTVE-DDGRDNRDRVFCK----CNHLTSFSIL--MSPDSPDPGSLL 1088

  Fly   246 KIINSYAMMFSIPFMMLTIAVYLLIPEL--------RNQHGKSLVCYLIGLSVGYSSLCYVQL-- 300
            ||:........:.|.::::|..|::..:        |..:.:.:....|.|.:..:.:.::..  
  Rat  1089 KILLDIISYIGLGFSIVSLAACLVVEAMVWKSVTKNRTSYMRHICIVNIALCLLIADIWFIVAGA 1153

  Fly   301 -----YQVDATGVTCKVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGI----NRFQEKKRFLF 356
                 |.::.|  .|....:..:||::..:.|:..:...|::     |.|    :..:..::.:.
  Rat  1154 IHDGHYPLNET--ACVAATFFIHFFYLSVFFWMLTLGLMLFY-----RLIFILHDASKSTQKAIA 1211

  Fly   357 YSLYSWGIALVFLAFTYCAQQLTNLPANLKPGIGDGVY-----CWLDMSNWAAMIYFYGPILAIV 416
            :|| .:|..|:..:.|....|    |..        ||     |||:..:..|::.|..|.|.||
  Rat  1212 FSL-GYGCPLIISSITVGVTQ----PQE--------VYMRKNACWLNWEDTRALLAFAIPALIIV 1263

  Fly   417 VANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITW 481
            |.|..:.::.          :.:|:......|..:.||...|..:.|   .|:   |..::|:||
  Rat  1264 VVNVSITVVV----------ITKILRPSVGDKPGKQEKSSLFQISKS---IGV---LTPLLGLTW 1312

  Fly   482 LTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLF--VMKKKVKHLITNRCSSVRDGSNQRQS 544
            ...|.:...||:..:..:|   .|.||.|| |..:||  :..:||:..:.::.|..|     ..|
  Rat  1313 GFGLATVIQGSNAVFHIIF---TLLNAFQG-LFILLFGCLWDQKVQEALLHKFSLSR-----WSS 1368

  Fly   545 QYSTKTTSSSVANLSLHEKP---------------SVEKPLVISSSVD 577
            |:|..|:..|...:.....|               :|..|...||||:
  Rat  1369 QHSKSTSLGSSTPVFSMSSPISRRFNNLFGKTGTYNVSTPETTSSSVE 1416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl10NP_788446.2 Methuselah_N 56..236 CDD:429053 14/54 (26%)
7tmB3_Methuselah-like 242..533 CDD:410632 63/316 (20%)
TM helix 1 244..269 CDD:410632 4/24 (17%)
TM helix 2 278..300 CDD:410632 2/21 (10%)
TM helix 3 311..338 CDD:410632 4/26 (15%)
TM helix 4 354..374 CDD:410632 5/19 (26%)
TM helix 5 401..430 CDD:410632 8/28 (29%)
TM helix 6 446..489 CDD:410632 11/42 (26%)
TM helix 7 497..522 CDD:410632 9/26 (35%)
Adgrf5XP_038938942.1 TM helix 6 1298..1320 CDD:410628 7/27 (26%)
TM helix 7 1325..1350 CDD:410628 9/28 (32%)
SEA 181..271 CDD:460188
IG_like 298..372 CDD:214653
Ig strand B 302..306 CDD:409353
Ig strand C 315..318 CDD:409353
Ig strand E 329..350 CDD:409353
ig 550..627 CDD:395002
Ig strand B 563..567 CDD:409353
Ig strand C 576..579 CDD:409353
Ig strand E 603..607 CDD:409353
Ig strand F 617..622 CDD:409353
GPS 1029..1076 CDD:460350 14/49 (29%)
7tm_GPCRs 1090..1363 CDD:475119 61/312 (20%)
TM helix 1 1092..1116 CDD:410628 3/23 (13%)
TM helix 2 1131..1152 CDD:410628 2/20 (10%)
TM helix 3 1167..1189 CDD:410628 3/21 (14%)
TM helix 4 1210..1226 CDD:410628 4/16 (25%)
TM helix 5 1248..1271 CDD:410628 8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

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