Protein Alignment mthl10 and ADGRG5

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_011521251.2
• Gene: ADGRG5 / 221188
• HGNCID: 19010
• Length: 592
• Species: Homo sapiens
• Alignment Length: 382
• Identity: 64/382 - (16%)
• Similarity: 125/382 - (32%)
• Gaps: 123/382 - (32%)

  Fly   233 PANC-DMQDDHSTVKIINSYAMMFSIPFMMLTIAVY---LLIPELRNQHGKSLVCY--LIGLSVG 291
            |..| ..|..||.|....::...|:: .|.|:.|:.   ||.|          :.|  |:|.|:.
Human   270 PEGCRTEQPSHSQVLCRCNHLTYFAV-LMQLSPALVPAELLAP----------LTYISLVGCSIS 323

  Fly   292 -YSSLCYVQLY-----QVDA------------------------------TGVTCKVFGYTAYFF 320
             .:||..|.|:     |.|:                              .|..|.......::.
Human   324 IVASLITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFLLSPAFAMSPVPGSACTALAAALHYA 388

  Fly   321 FMGAYMWLSVISFDLW------HNFRGTRGINRFQEKKRFLF-YSLYSWGIALVFLAFTYCAQQL 378
            .:....|:::..|:|:      :|.          ..:|::| ..:..||...:.:..:...:..
Human   389 LLSCLTWMAIEGFNLYLLLGRVYNI----------YIRRYVFKLGVLGWGAPALLVLLSLSVKSS 443

  Fly   379 TNLPANLK--------PGIGDGVYCWL-DMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQ 434
            ...|..:.        .|..:...||: .....:.::..||.:.::.....:.:.:..:
Human   444 VYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYGGLTSLFNLVVLAWALWTL------ 502

  Fly   435 REMARIIASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKL 499
                         :.||...|....||.  :.....|.|.:::|.||.....|:.|
Human   503 -------------RRLRERADAPSVRAC--HDTVTVLGLTVLLGTTWALAFFSFGV--------- 543

  Fly   500 F-----YISDLANAMQGFLIFMLFVMKKKVKHLITNRCSSVRDGSNQRQSQYSTKTT 551
            |     ::..:.|::.||.:|:.|         .:.||.|..:...|.::..|::||
Human   544 FLLPQLFLFTILNSLYGFFLFLWF---------CSQRCRSEAEAKAQIEAFSSSQTT 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	1/2 (50%)
		7tmB3_Methuselah-like	242..533	CDD:410632	55/352 (16%)
		TM helix 1	244..269	CDD:410632	5/27 (19%)
		TM helix 2	278..300	CDD:410632	7/24 (29%)
		TM helix 3	311..338	CDD:410632	3/32 (9%)
		TM helix 4	354..374	CDD:410632	3/20 (15%)
		TM helix 5	401..430	CDD:410632	2/28 (7%)
		TM helix 6	446..489	CDD:410632	11/42 (26%)
		TM helix 7	497..522	CDD:410632	6/29 (21%)
ADGRG5	XP_011521251.2	GPS	252..296	CDD:460350	7/26 (27%)
		7tmB2_GPR114	309..582	CDD:320559	49/331 (15%)
		TM helix 1	311..336	CDD:320559	9/34 (26%)
		TM helix 2	345..367	CDD:320559	0/21 (0%)
		TM helix 3	379..406	CDD:320559	3/26 (12%)
		TM helix 4	419..439	CDD:320559	3/19 (16%)
		TM helix 5	473..502	CDD:320559	2/28 (7%)
		TM helix 6	515..542	CDD:320559	8/28 (29%)
		TM helix 7	546..571	CDD:320559	5/33 (15%)