Protein Alignment mthl10 and LOC1280992

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: XP_320866.3
• Gene: LOC1280992 / 1280992
• VectorBaseID: AGAMI1_010236
• Length: 682
• Species: Anopheles gambiae
• Alignment Length: 479
• Identity: 92/479 - (19%)
• Similarity: 183/479 - (38%)
• Gaps: 112/479 - (23%)

  Fly   111 VCKFKSCLNICCPWRQVFNSEVDGCIIDHSD--NRTWPDPPMLNITFRNESTILVNMFTQFAIQS 173
            |.:..|.:..|||..:...||....:....|  :...|.|             :|..|.:..|:.
Mosquito   203 VSRDASIMRKCCPPGESLVSEHSKHVSCQKDAPSSYLPQP-------------IVAQFYRDCIED 254

  Fly   174 F-----------RPCPK---MFSLQPETNNWDDYLLFENGSMLRVDDKLLIRKNEFCMVPTYVNE 224
            .           .|||.   |.|....||  |...:.:|||:|     ::....::.:..||..:
Mosquito   255 LEEELRLDVRYGNPCPSEGGMVSFGAHTN--DTLYVIQNGSLL-----VIYGGKDYDVYDTYCLD 312

  Fly   225 SD-----MFYTIHPANCDMQDDHSTVK---IINSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSL 281
            .|     :...:.|:...:..|  .||   .:.:..::.:||.:::|..:|:::|:|.:.||::|
Mosquito   313 YDRTDGALLAYVCPSEVRVMVD--VVKGQLFLLTICLIVAIPALLVTALLYIIVPKLHDLHGRAL 375

  Fly   282 VCYLIGLSVGYSSLCYVQLYQVDATG----VTCKVFGYTAYFFFMGAYMWLSV----ISFDLWHN 338
            ....:..::.....|:   :|....|    :...|....|.:|.:..:.||.|    ..|..|:.
Mosquito   376 AMNCVNFAIALLLECF---FQYRNRGKRMLMDDMVLENYAEYFILATFFWLLVNCGNNCFHAWYY 437

  Fly   339 FRGTRGINRFQEKKRFLFYSLYSWGIAL-VFLAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSNW 402
            ....:..|..::.:||..|:.::..|.| :.|:::.       .||. .|.|..
Mosquito   438 VPRGKKANTLEDNQRFALYAAFAQLIPLWIILSYSM-------TPAG-TPAIKH----------- 483

  Fly   403 AAMIYFYGPILAIVVANTIMFIMTAIKI----------HGVQREMARIIASENSTKNLRT---EK 454
                |.:.||...:...::..::|.:.:          |.:::.:.:....|...|.:..   :.
Mosquito   484 ----YLFIPIGVTLGLGSLCLLVTLLGLTRLKNCYYTCHQIRQRLVQSGQYEELCKYVPVCGRKV 544

  Fly   455 DKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLFV 519
            :|..|  .:.|.    :.||::||..|....::|:...|   ..:||  |:....||.|:|::||
Mosquito   545 NKVIY--MNKYT----VPLFVVMGTIWTVMAVTYYATYD---LPIFY--DILFGFQGILMFVIFV 598

  Fly   520 MKKKVKHLITNRCSSVRDGSNQRQ 543
                   .:.....::|...|:|:
Mosquito   599 -------CMPRPYETIRQWLNERR 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	29/145 (20%)
		7tmB3_Methuselah-like	242..533	CDD:410632	59/315 (19%)
		TM helix 1	244..269	CDD:410632	6/27 (22%)
		TM helix 2	278..300	CDD:410632	3/21 (14%)
		TM helix 3	311..338	CDD:410632	8/30 (27%)
		TM helix 4	354..374	CDD:410632	5/20 (25%)
		TM helix 5	401..430	CDD:410632	4/28 (14%)
		TM helix 6	446..489	CDD:410632	9/45 (20%)
		TM helix 7	497..522	CDD:410632	9/24 (38%)
LOC1280992	XP_320866.3	None