Protein Alignment mthl10 and Calcr

DIOPT Version :10

• Sequence 1: NP_788446.2
• Gene: mthl10 / 38057
• FlyBaseID: FBgn0035132
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_031614.2
• Gene: Calcr / 12311
• MGIID: 101950
• Length: 533
• Species: Mus musculus
• Alignment Length: 460
• Identity: 72/460 - (15%)
• Similarity: 143/460 - (31%)
• Gaps: 187/460 - (40%)

  Fly   142 NRT------WPDPPMLNITFRNESTILVNMFTQFAIQSFRPCPKMFSLQPETNNWDDYLLF--EN 198
            |||      |.|.|.                   ...:::.||..|   |:.:..:....:  ||
Mouse    90 NRTWDGWMCWDDTPA-------------------GATAYQHCPDYF---PDFDTAEKVSKYCDEN 132

  Fly   199 GSMLRVDDKLLIRKNEFCMVPTYVNESDMFYTIHPANCDMQDDHSTVKIINSYAMMF-------- 255
            |...|..|.               |.:...||:    |:.   .::.|:.|:|.:.:
Mouse   133 GEWFRHPDS---------------NRTWSNYTL----CNA---FTSEKLQNAYVLYYLALVGHSL 175

  Fly   256 SIPFMMLTIAVYLLIPELRNQ----HGKSLVCYLIGLSVGYSSLCYVQLYQVDATG--------- 307
            ||..::.::.::.:...|..|    |....:.|::.     |.:..:.|.:|...|
Mouse   176 SIAALVASMLIFWIFKNLSCQRVTLHKHMFLTYILN-----SIIIIIHLVEVVPNGDLVRRDPMH 235

  Fly   308 -----------------------------------VTCKVFGYTAYFFFMGAYMWL--------S 329
                                               ::|||..:...:.....|.|:        :
Mouse   236 IFHHNTHMWTMQWELSPPLPLSAHEGKMDPHASEVISCKVLHFLHQYMMSCNYFWMLCEGIYLHT 300

  Fly   330 VISFDLWHNFRGTRGINRFQEKKRFLFYSLYSWGIALV---FLAFTYCAQQLTNLPANLKPGIGD 391
            :|...:            |.:::|..:|.|..||..:|   ..|.|.......|
Mouse   301 LIVMAV------------FTDEQRLRWYYLLGWGFPIVPTIIHAITRALYYNDN----------- 342

  Fly   392 GVYCWLDMSNWAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDK 456
               |||........| .:||::..:|.| ..|::..:          |::.    ||..:|.:.:
Mouse   343 ---CWLSAETHLLYI-IHGPVMVALVVN-FFFLLNIV----------RVLV----TKMRQTHEAE 388

  Fly   457 RFYRAWSNYRFGLFLR-------LFLIMGITWLTELISYFVGSDKGWSKLF-YISDLANAMQGFL 513
            .:          ::|:       |..::||.:   ::..:..|:|...|:: |:.......|||.
Mouse   389 SY----------MYLKAVKATMVLVPLLGIQF---VVFPWRPSNKVLGKIYDYLMHSLIHFQGFF 440

  Fly   514 IFMLF 518
            :..::
Mouse   441 VATIY 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:429053	18/101 (18%)
		7tmB3_Methuselah-like	242..533	CDD:410632	53/352 (15%)
		TM helix 1	244..269	CDD:410632	5/32 (16%)
		TM helix 2	278..300	CDD:410632	2/21 (10%)
		TM helix 3	311..338	CDD:410632	5/34 (15%)
		TM helix 4	354..374	CDD:410632	7/22 (32%)
		TM helix 5	401..430	CDD:410632	6/28 (21%)
		TM helix 6	446..489	CDD:410632	7/49 (14%)
		TM helix 7	497..522	CDD:410632	5/23 (22%)
Calcr	NP_031614.2	HRM	86..154	CDD:397086	19/107 (18%)
		7tmB1_calcitonin_R	162..472	CDD:341343	51/344 (15%)
		TM helix 1	164..189	CDD:341343	2/24 (8%)
		TM helix 2	198..220	CDD:341343	3/26 (12%)
		TM helix 3	274..301	CDD:341343	4/26 (15%)
		TM helix 4	313..333	CDD:341343	5/19 (26%)
		TM helix 5	348..377	CDD:341343	7/40 (18%)
		TM helix 6	391..418	CDD:341343	4/29 (14%)
		TM helix 7	424..449	CDD:341343	5/22 (23%)