DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl10 and adgre14

DIOPT Version :9

Sequence 1:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_021330419.1	Gene:	adgre14 / 108182849	ZFINID:	ZDB-GENE-131120-49	Length:	505	Species:	Danio rerio

Alignment Length:	439	Identity:	80/439 - (18%)
Similarity:	162/439 - (36%)	Gaps:	85/439 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 SEVDGCIIDHSDNRTWPDPPMLNITFRNESTILVNMFTQFAIQSFRPCPKMFSLQPETNNWDDYL 194
            |.|....:..:.|.....|  :|.|||:             |:.|.|......:....:.|
Zfish   130 SSVISVTLPKTTNTALSKP--VNFTFRH-------------IREFDPSGSFSCVYWNISKW---- 175

  Fly   195 LFENGSMLRVDDKL----LIRKNEFCMVPTYVNESDMFYTIHPANCDMQDDHSTVKIINSYAMMF 255
            :.:..|:|..:...    .:..:.|.::        |....||...|     |.:.::|...::.
Zfish   176 IVDGCSVLNTNRSFTVCSCVHLSTFALI--------MQTRSHPPESD-----SLLNVLNVVCVIV 227

  Fly   256 SIPFMMLTIAVYLLI---PELRNQHGKSLVCYLIGLSVGYSSLCYVQ--LYQVDATGVTCKVFGY 315
            .:.|..|.:..:...   |.:.|. .:..:|  |.|.:.:......|  |..:....|.|.:...
Zfish   228 GLLFFSLALLTFTRCQWSPGVNNV-ARINIC--ISLLLAHLLFLLTQQFLSLIRRQKVLCMLISG 289

  Fly   316 TAYFFFMGAYMWLSVISFDLWHNFRGTRGI-NRFQEKKRFLFYSLYSWGIALVFLAFTYCAQQLT 379
            ..:|.|:..::|:.:.:..|:...:....| ::.:...|.....:..:.:|||          :.
Zfish   290 LLHFLFLSGFVWMFIEAVLLFICVKNLSQISSQMKNVLRNKLLCVIGYAVALV----------VV 344

  Fly   380 NLPANLKPGIGDGVYCWLDMSN---WAAMIYFYGPILAIVVANTIMFIMTAIKIHGVQREMARII 441
            ::.|.:.|.......||:.|..   |:    |.||:..|:..|.|:||.....:....:::...:
Zfish   345 SISAAVVPNGYGSEKCWIQMHKGFIWS----FLGPVTIIIALNVILFISIGFSLKSAFKKLNADV 405

  Fly   442 ASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFVGSDKGWSKLFYISDLA 506
            :..|.||.:..:.                |..|:::|.:|   ::.:|..|.|....||.|   .
Zfish   406 SQLNQTKIVMFKT----------------LAQFVVLGCSW---ILGFFTNSSKVLEILFLI---L 448

  Fly   507 NAMQGFLIFMLF-VMKKKVKHLITNRCSSVRDGSNQRQSQYSTKTTSSS 554
            |:.||..||::: |:.|.::.......:|:..|...:...:|::.|..|
Zfish   449 NSQQGTFIFLIYCVLNKGIRQEYRKLFTSLYSGLKPKNFNWSSENTEDS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145	18/109 (17%)
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	51/278 (18%)
adgre14	XP_021330419.1	GPS	167..205	CDD:197639	4/49 (8%)
		7tm_GPCRs	214..476	CDD:333717	57/305 (19%)
		TM helix 1	217..241	CDD:320095	3/23 (13%)
		TM helix 2	250..271	CDD:320095	4/23 (17%)
		TM helix 3	285..307	CDD:320095	3/21 (14%)
		TM helix 4	331..347	CDD:320095	3/25 (12%)
		TM helix 5	365..388	CDD:320095	7/26 (27%)
		TM helix 6	412..435	CDD:320095	5/41 (12%)
		TM helix 7	439..464	CDD:320095	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153592at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920