DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl10 and adgre13

DIOPT Version :9

Sequence 1:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_021327151.1	Gene:	adgre13 / 100538238	ZFINID:	ZDB-GENE-150505-3	Length:	303	Species:	Danio rerio

Alignment Length:	325	Identity:	63/325 - (19%)
Similarity:	133/325 - (40%)	Gaps:	55/325 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 STVKIINSYAMMFSIPFMMLTIAVYLLI---PELRNQHGKSLVCYLIGLSVGYSSLCYVQ--LYQ 302
            |.:.::|...::..:.|..|.:..:...   |.:.|. .:..:|  |.|.:.:......|  |..
Zfish    13 SLLNVLNVVCVIVGLLFFSLALLTFAFCQWGPGVNNV-ARINIC--ISLLLAHLLFLLTQQFLSL 74

  Fly   303 VDATGVTCKVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQEKK----RFLFYSLYSWG 363
            :....:.|:|.....:|.|:..::|:.:.:..|   |...:.:::...:|    |.:|..:..:.
Zfish    75 IRRQQMLCEVISGLLHFLFLSGFVWMFIEAVLL---FICVKNLSQISSQKRNVLRNIFLCVIGYA 136

  Fly   364 IALVFLAFTYCAQQLTNLPANLKPGIGDGVYCWLDMSN---WAAMIYFYGPILAIVVANTIMFIM 425
            :|||.:..:         .|.:..|.| ...||:.|..   |:    |.||:..|:..|.|:||.
Zfish   137 VALVVVGIS---------AAVVPKGYG-SEKCWIKMDKGFIWS----FLGPVTVILALNVILFIG 187

  Fly   426 TAIKIHGVQREMARIIASENSTKNLRTEKDKRFYRAWSNYRFGLFLRLFLIMGITWLTELISYFV 490
            ..:.:....:::...::..|.||.:..:.                |..|:::|.:|   ::.:|.
Zfish   188 IGVSLKSAFKKLNADVSQLNQTKIIMFKT----------------LAQFVVLGCSW---ILGFFT 233

  Fly   491 GSDKGWSKLFYISDLANAMQGFLIFMLF-VMKKKVKHLITNRCSSVRDGSNQRQSQYSTKTTSSS 554
            .|.|....||.|   .|:.||..||::: |:.|.::.......:|:..|...:...::::.|..|
Zfish   234 NSSKVLEILFLI---LNSQQGTFIFLIYCVLNKGIRQEYRKLFTSLYCGLKPKNINWTSENTEDS 295

Fly 555 554
Zfish 296 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	54/281 (19%)
adgre13	XP_021327151.1	7tm_GPCRs	12..274	CDD:333717	59/302 (20%)
		TM helix 1	15..39	CDD:320095	3/23 (13%)
		TM helix 2	48..69	CDD:320095	4/23 (17%)
		TM helix 3	83..105	CDD:320095	4/21 (19%)
		TM helix 4	129..145	CDD:320095	4/15 (27%)
		TM helix 5	163..186	CDD:320095	7/26 (27%)
		TM helix 6	210..233	CDD:320095	5/41 (12%)
		TM helix 7	237..262	CDD:320095	10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1153592at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010