DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl10 and gpr157

DIOPT Version :9

Sequence 1:	NP_788446.2	Gene:	mthl10 / 38057	FlyBaseID:	FBgn0035132	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001124512.1	Gene:	gpr157 / 100038048	XenbaseID:	XB-GENE-492646	Length:	323	Species:	Xenopus tropicalis

Alignment Length:	367	Identity:	76/367 - (20%)
Similarity:	137/367 - (37%)	Gaps:	96/367 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 QDDHSTVKIINSYAMMFSIPFMMLTIAVYLLIPELRNQHGKSLVCYLIGLSVGYSSLCYVQLYQV 303
            :|.:.:.::|...:.:.|.....|.|..|:|..:||::  ..|:...:.::...|:|.|  .|.|
Frog     9 EDLNVSEQVIVLLSCVLSFLGSALIIVTYILWQDLRSR--PRLLLLFLSVADLLSALSY--FYGV 69

  Fly   304 -----DATGVTCKVFGYTAYFFFMGAYMWLSVISFDLWHNFRGTRGINRFQEKKRFL-----FYS 358
                 |:|. .|...|..:.|....::.|...::..|:        |...:.::.|.     :..
Frog    70 LRNFQDSTW-DCVTQGAISTFSNTSSFFWTVAVAVYLY--------ITIVKSQQSFADQIIPWLH 125

  Fly   359 LYSWGIALVFLAFTYCAQQLTNLPANLKPGIGDGVYCW--LDMSN-----------WAAMIYFYG 410
            |.|||:.||......|.:::....:.:..|     :||  :|:.:           |..:.|...
Frog   126 LISWGVPLVITLSAVCLKKIGYDASYVSVG-----WCWVKIDVEDKLLWMLLAGKVWEILAYLIL 185

  Fly   411 PILAIVVANTIMFIMTAIKIHGVQREMARIIASENSTKNLRTEKDKR---------FYRAWSNYR 466
            |:|.|::...|.      :.|....|...|:|: :.....||..||:         |.|.||..|
Frog   186 PVLYILIKKHIG------RAHAALAEYRPILAT-SPVNQPRTIADKKLVFIPIIFIFLRVWSTIR 243

  Fly   467 FGLFL---------RLFLIMGITWLTELISYFVGSDKGWSKLFYISDLANAMQGFLIFMLFVMKK 522
            |.|.|         .|..:.||                          .|..||....::||:..
Frog   244 FILTLCDSPAVHNPILVTLHGI--------------------------GNTFQGGANCIMFVLCT 282

  Fly   523 KV--KHLITNRCSSVRDGSNQRQSQYSTKTTSSSVANLSLHE 562
            .|  ..|::..|...|  |::|:::.||:.|..|.|...:::
Frog   283 PVIRSRLVSLLCGCSR--SSRRENETSTRRTYGSTAGTPVNQ 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl10	NP_788446.2	Methuselah_N	56..236	CDD:284145
mthl10	NP_788446.2	7tm_4	244..514	CDD:304433	62/310 (20%)
gpr157	NP_001124512.1	7tm_GPCRs	17..>192	CDD:391938	39/192 (20%)
		TM helix 1	17..39	CDD:341315	5/21 (24%)
		TM helix 2	48..69	CDD:341315	5/22 (23%)
		TM helix 3	81..103	CDD:341315	3/21 (14%)
		TM helix 4	123..139	CDD:341315	6/15 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	49	1.000	Inparanoid score	I5275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960