Protein Alignment mthl9 and ADGRE5

DIOPT Version :10

• Sequence 1: NP_612029.1
• Gene: mthl9 / 38056
• FlyBaseID: FBgn0035131
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_510966.1
• Gene: ADGRE5 / 976
• HGNCID: 1711
• Length: 835
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 75/375 - (20%)
• Similarity: 147/375 - (39%)
• Gaps: 107/375 - (28%)

  Fly   140 RTELGCRNKFVDKKHDNFWQWDLFENGTLRRDNRLWSTD--------------------EYCFSP 184
            |.||.|.          ||:.|....|.       |:|:                    .:....
Human   490 RQELLCA----------FWKSDSDRGGH-------WATEGCQVLGSKNGSTTCQCSHLSSFAILM 537

  Fly   185 LEHNPEQWELTPLNCERFQTGYRVWIYAICSIIAIIINIFILSLLGSVRDARKSHYGQLIIYYLL 249
            ..::.|.|:||.:.    :.|..:.::  |.::.|:..:.:..:.||    |.:    :.::..:
Human   538 AHYDVEDWKLTLIT----RVGLALSLF--CLLLCILTFLLVRPIQGS----RTT----IHLHLCI 588

  Fly   250 SMIVGYSLLVYLA-LKNPMKLSHVACRNIGFLAYFCIMLSFVFLAICSLD--FLLKFKQKAVRSS 311
            .:.||.:  ::|| ::|......:.||.:..|.::|.:.:|.::::..|:  ||:....:....|
Human   589 CLFVGST--IFLAGIENEGGQVGLRCRLVAGLLHYCFLAAFCWMSLEGLELYFLVVRVFQGQGLS 651

  Fly   312 VRRLSL-ALAV-LAVIGLRFLVSLAQDSKLPKHFKPGMGED-YCWFDVRTWGILIYYYGPIALLL 373
            .|.|.| ...| |.::|    ||.|..||       |.|.. |||.|... |.|..:.||:..::
Human   652 TRWLCLIGYGVPLLIVG----VSAAIYSK-------GYGRPRYCWLDFEQ-GFLWSFLGPVTFII 704

  Fly   374 IFSIVCCLKAYFSI----YELPPDTQYILGTQLKIVKTHFYAFSA----YIVG---VFAVWIRE- 426
            :.:.|..:...:.:    .|:.||.:       |:.|......:|    :::|   ||.::|.:
Human   705 LCNAVIFVTTVWKLTQKFSEINPDMK-------KLKKARALTITAIAQLFLLGCTWVFGLFIFDD 762

  Fly   427 ---IVVYIMARVREHFFIIDFWSGICILGLAIAGFILLLGKNL--HVKSW 471
               ::.|:       |.|::     |:.|..:.....||.|.:  ..:.|
Human   763 RSLVLTYV-------FTILN-----CLQGAFLYLLHCLLNKKVREEYRKW 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl9	NP_612029.1	Methuselah_N	29..199	CDD:429053	14/78 (18%)
		7tmB3_Methuselah-like	232..473	CDD:410632	56/263 (21%)
		TM helix 2	241..263	CDD:410632	4/22 (18%)
		TM helix 3	275..302	CDD:410632	7/28 (25%)
		TM helix 4	314..334	CDD:410632	7/21 (33%)
		TM helix 5	358..387	CDD:410632	5/28 (18%)
		TM helix 6	404..431	CDD:410632	6/37 (16%)
		TM helix 7	440..465	CDD:410632	5/24 (21%)
ADGRE5	NP_510966.1	EGF_CA	64..96	CDD:429571
		EGF_CA	116..>148	CDD:214542
		EGF_CA	160..191	CDD:429571
		EGF_CA	209..240	CDD:429571
		GPS	494..536	CDD:460350	7/58 (12%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	495..543		7/64 (11%)
		7tmB2_CD97	544..806	CDD:320554	64/304 (21%)
		TM helix 1	546..571	CDD:320554	5/30 (17%)
		TM helix 2	580..602	CDD:320554	4/27 (15%)
		TM helix 3	613..640	CDD:320554	5/26 (19%)
		TM helix 4	652..672	CDD:320554	8/23 (35%)
		TM helix 5	689..718	CDD:320554	5/29 (17%)
		TM helix 6	734..761	CDD:320554	6/26 (23%)
		TM helix 7	765..790	CDD:320554	6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	814..835