Protein Alignment mthl9 and ADGRG7

DIOPT Version :10

• Sequence 1: NP_612029.1
• Gene: mthl9 / 38056
• FlyBaseID: FBgn0035131
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_116176.2
• Gene: ADGRG7 / 84873
• HGNCID: 19241
• Length: 797
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 84/423 - (19%)
• Similarity: 153/423 - (36%)
• Gaps: 137/423 - (32%)

  Fly   149 FVDKKHDNFWQWDLFENGTLRRD--NRLWS--TDE----------YCFSPLEHNPEQWELTPLNC 199
            ||..::|..:|...|   |.:.|  .::.|  |||          ..||| ::|.::::|....|
Human   323 FVVYQNDKLFQSKTF---TAKSDFSQKIISSKTDENEQDQSASVDMVFSP-KYNQKEFQLYSYAC 383

  Fly   200 ERFQTGYRVWIYAIC-----------------SIIAIII----------NIFILSLLGS------ 231
            ..:....:.|....|                 :..|:::          ::.|||.:|.
Human   384 VYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNVGCALSVTG 448

  Fly   232 ----------VRDARKSHYGQLIIYYLLSMIVGYSLLVYLALKNPMK------------------ 268
                      .|..||:....:::...:||:: ::||....::|..|
Human   449 LALTVIFQIVTRKVRKTSVTWVLVNLCISMLI-FNLLFVFGIENSNKNLQTSDGDINNIDFDNND 512

  Fly   269 --------LSHVACRNIGFLAYFCIMLSFVF--LAICSLDFLLKFKQKAV-RSSVRRLSL----- 317
                    :.:..|..|..|.::.::::|.:  |:...|.:||....|.: |..:..:||
Human   513 IPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGV 577

  Fly   318 -ALAVLAVIGLRFLVSLAQDSKLPKHFKPGMGEDYCWFDV----------RTWGILIYYYGPIAL 371
             |:.|...:|    |..:|:...|:.......|..||..:          ..|..::    |:.:
Human   578 PAIVVAITVG----VIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIV----PVTI 634

  Fly   372 LLIFSIVCCLKAYFSIYELPPDTQYILGTQ-----LKIVKTHFYAFSAYIVGVFAVWIREIVVYI 431
            :||.::|..:.  .||..|..:.|.:..|:     .|||.|   ...|.:.|:  .|   |:.|:
Human   635 ILISNVVMFIT--ISIKVLWKNNQNLTSTKKVSSMKKIVST---LSVAVVFGI--TW---ILAYL 689

  Fly   432 MARVREHFFIIDFWSGICIL----GLAIAGFIL 460
            |. |.:....|.|....|:.    ||.|  |||
Human   690 ML-VNDDSIRIVFSYIFCLFNTTQGLQI--FIL 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl9	NP_612029.1	Methuselah_N	29..199	CDD:429053	16/63 (25%)
		7tmB3_Methuselah-like	232..473	CDD:410632	60/283 (21%)
		TM helix 2	241..263	CDD:410632	4/21 (19%)
		TM helix 3	275..302	CDD:410632	6/28 (21%)
		TM helix 4	314..334	CDD:410632	6/25 (24%)
		TM helix 5	358..387	CDD:410632	5/28 (18%)
		TM helix 6	404..431	CDD:410632	7/26 (27%)
		TM helix 7	440..465	CDD:410632	9/25 (36%)
ADGRG7	NP_116176.2	GPS	381..421	CDD:460350	4/39 (10%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	383..428		4/44 (9%)
		7tmB2_GPR128	431..737	CDD:320385	64/311 (21%)
		TM helix 1	433..458	CDD:320385	4/24 (17%)
		TM helix 2	468..490	CDD:320385	4/22 (18%)
		TM helix 3	527..554	CDD:320385	5/26 (19%)
		TM helix 4	567..587	CDD:320385	4/19 (21%)
		TM helix 5	621..651	CDD:320385	7/35 (20%)
		TM helix 6	665..692	CDD:320385	10/35 (29%)
		TM helix 7	699..724	CDD:320385	9/23 (39%)