DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mthl9 and adgre5b.3

DIOPT Version :10

Sequence 1:NP_612029.1 Gene:mthl9 / 38056 FlyBaseID:FBgn0035131 Length:513 Species:Drosophila melanogaster
Sequence 2:XP_005160275.1 Gene:adgre5b.3 / 792970 ZFINID:ZDB-GENE-121214-275 Length:756 Species:Danio rerio


Alignment Length:396 Identity:85/396 - (21%)
Similarity:141/396 - (35%) Gaps:117/396 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 WDLFENGTLRRDNRL-WSTDEYCFSPLEHNPE---QWELTPLNCERFQTGYRVWIYAICSIIAII 220
            |...|.|...|...| ||...:......|...   ...|.|:. :.|:......:..:.|:|.:|
Zfish   419 WSESERGWSGRGCELAWSNSTHTACSCSHLSSFAVLMALYPVE-DTFELVVITRVGLVLSLICLI 482

  Fly   221 INIFILSLLGSVRDARKSHYGQLIIYYLLSMIVGYSLLVYLALKNPMKLSH--VACRNIG----- 278
            :.|.......|::..|.|      |:..||:.:..:.||:|.   .:..:|  |||..:.     
Zfish   483 LCILTFRFCRSIQGTRNS------IHLHLSVCLFIADLVFLC---GISSTHNQVACAIVAGLLHF 538

  Fly   279 -FLAYFCIML--------SFVFLAICSLDFLLKFKQKAVRSSVRRLSLALAVLAVIGLRFLVSLA 334
             ||:.||.||        ..|.:...:|..|..:   ||...|..:.::::.:||          
Zfish   539 FFLSAFCWMLLEGVQLYRMVVLVFHTTLKHLYMY---AVGYGVPLVIVSISAIAV---------- 590

  Fly   335 QDSKLPKHFKPGMGED-YCWFDVRTWGILIYYYGPIALLLIFS----IVCCLKAYFSIYELPPDT 394
                 ||    |.|.| :||..:..:.||.::. |:.:::|.:    |:...|.......|.|| 
Zfish   591 -----PK----GYGTDRHCWLSLEGYLILSFFI-PVCIIVILNITVFIITVWKLALKFSSLNPD- 644

  Fly   395 QYILGTQLKIVKTH-FYAFSAYIVGVFAV----WI----------REIVVYIMARVREHFFIIDF 444
                     :.|.| ..:|.|..|....|    |:          .|:::|:       |.|::.
Zfish   645 ---------LSKLHKIRSFLATAVAQLCVLGGSWVFGFFLFQKNGTEVMLYL-------FIILNS 693

  Fly   445 WSGICILGLAIAGFIL--LLGKNLHVKSWWAINVESSQTDLSIINARVYKFDEKGD-----LKSS 502
            ..|..|       ||:  ||.|.:.|             :...:..|:....:|||     .:.|
Zfish   694 LQGALI-------FIMHCLLSKQVRV-------------EYRSLFMRMCSNKKKGDYSVSSTEPS 738

  Fly   503 DSPYKP 508
            .|..||
Zfish   739 HSSQKP 744

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl9NP_612029.1 Methuselah_N 29..199 CDD:429053 10/42 (24%)
7tmB3_Methuselah-like 232..473 CDD:410632 61/278 (22%)
TM helix 2 241..263 CDD:410632 6/21 (29%)
TM helix 3 275..302 CDD:410632 9/40 (23%)
TM helix 4 314..334 CDD:410632 2/19 (11%)
TM helix 5 358..387 CDD:410632 6/32 (19%)
TM helix 6 404..431 CDD:410632 8/41 (20%)
TM helix 7 440..465 CDD:410632 7/26 (27%)
adgre5b.3XP_005160275.1 EGF_CA 32..>62 CDD:214542
EGF_CA 72..103 CDD:429571
EGF_CA <121..152 CDD:214542
EGF_CA 154..188 CDD:214542
GPS 416..460 CDD:197639 9/40 (23%)
7tm_GPCRs 463..723 CDD:475119 68/328 (21%)
TM helix 1 466..490 CDD:410628 4/23 (17%)
TM helix 2 499..520 CDD:410628 7/29 (24%)
TM helix 3 530..552 CDD:410628 6/21 (29%)
TM helix 4 570..586 CDD:410628 3/18 (17%)
TM helix 5 605..628 CDD:410628 4/23 (17%)
TM helix 6 655..677 CDD:410628 4/21 (19%)
TM helix 7 682..707 CDD:410628 9/38 (24%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.