Protein Alignment mthl9 and Adgrf4

DIOPT Version :10

• Sequence 1: NP_612029.1
• Gene: mthl9 / 38056
• FlyBaseID: FBgn0035131
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_084343.1
• Gene: Adgrf4 / 78249
• MGIID: 1925499
• Length: 698
• Species: Mus musculus
• Alignment Length: 356
• Identity: 63/356 - (17%)
• Similarity: 123/356 - (34%)
• Gaps: 116/356 - (32%)

  Fly   167 TLRRDNRLWSTDEYCFSPLEHNPE--QWELTPLNCERFQTGYRVWIYAICSIIAIIINIFILSLL 229
            |..:.|:..||...|.|   .:|.  ||:.:|..   ..:.....:...|.....:.:..||...
Mouse   339 TFDKINKSQSTSSQCVS---WDPATGQWDESPCT---VMSDINSTVKCRCRHTKAVTSFSILMSS 397

  Fly   230 GSVRDARKSHYGQLIIYYLLSMIVGYSLLVYLALKNPMKLSHVACRNIGFLAYFCI--------- 285
            ..|::...:|    |.:..||:.: :||::.|.:: .:..|.|....|.::.:.||
Mouse   398 KPVKNTILNH----ITFIGLSISI-FSLVLCLVIE-AIVWSRVVVTEISYMRHVCIVNIAVSLLT 456

  Fly   286 ---------------------------MLSFVFLAICSLDFLLKFK------------QKAVRSS 311
                                       :..|.||   ||.|.:.||            ::.::|.
Mouse   457 ANVWFIIGSNFSANVQEDHKWCVAVTFLCHFFFL---SLFFWMLFKALLIVYGILVVFRRMMKSR 518

  Fly   312 VRRLSLALA-----VLAVIGLRFLVSLAQDSKLPKHFKPGMG---EDYCWFDVRTWGILIYYYGP 368
            :..:..|:.     |:|||    .|::.:         ||.|   :|.||.:......|..:..|
Mouse   519 MMAIGFAIGYGCPLVIAVI----TVTVTE---------PGEGYTRKDACWLNWNQTKALFAFAIP 570

  Fly   369 IALLLIFSIVCCLKAYFSIYELPPDTQY-ILGTQ--------LKIVK-----------THFYAFS 413
            ...::..:::..|....       :||. ::|:.        .:|.|           |..:..:
Mouse   571 ALAIVAVNLLVVLAVAI-------NTQRPLIGSSKSQDMAIVFRISKNVAILTPLLGLTWGFGLT 628

  Fly   414 AYIVGVFAVWIREIVVYIMARVREHFFIIDF 444
            ..:.||..|:   .:::.:....:.|||:.|
Mouse   629 TLLEGVHLVF---HIIFALLNAFQGFFILLF 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl9	NP_612029.1	Methuselah_N	29..199	CDD:429053	10/33 (30%)
		7tmB3_Methuselah-like	232..473	CDD:410632	50/289 (17%)
		TM helix 2	241..263	CDD:410632	6/21 (29%)
		TM helix 3	275..302	CDD:410632	9/62 (15%)
		TM helix 4	314..334	CDD:410632	6/24 (25%)
		TM helix 5	358..387	CDD:410632	3/28 (11%)
		TM helix 6	404..431	CDD:410632	6/37 (16%)
		TM helix 7	440..465	CDD:410632	3/5 (60%)
Adgrf4	NP_084343.1	GPS	352..394	CDD:460350	7/47 (15%)
		7tm_GPCRs	402..669	CDD:475119	49/287 (17%)
		TM helix 1	405..429	CDD:320660	7/29 (24%)
		TM helix 2	444..465	CDD:320660	2/20 (10%)
		TM helix 3	479..501	CDD:320660	8/24 (33%)
		TM helix 4	522..538	CDD:320660	5/19 (26%)
		TM helix 5	560..583	CDD:320660	2/22 (9%)
		TM helix 6	609..631	CDD:320660	2/21 (10%)
		TM helix 7	636..661	CDD:320660	5/24 (21%)