Protein Alignment mthl9 and ADGRB2

DIOPT Version :10

• Sequence 1: NP_612029.1
• Gene: mthl9 / 38056
• FlyBaseID: FBgn0035131
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001351786.1
• Gene: ADGRB2 / 576
• HGNCID: 944
• Length: 1585
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 50/270 - (18%)
• Similarity: 92/270 - (34%)
• Gaps: 99/270 - (36%)

  Fly   165 NGTLRRDNRLWSTDEYC----FSPLEHNPEQWELTPLNCERFQT--------------------- 204
            |||         ||.:|    :|..:.:...|:..  ||:..:|
Human   867 NGT---------TDPHCASWDYSRADASSGDWDTE--NCQTLETQAAHTRCQCQHLSTFAVLAQP 920

  Fly   205 ------------------GYRVWIYAICSIIAIIINI--FILSLLGSVRDARKSHYGQLIIYYLL 249
                              |..|...|:.:::||....  ||           ||....:::.:.|
Human   921 PKDLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFI-----------KSERSIILLNFCL 974

  Fly   250 SMIVGYSLLVYLALKNPMKLSHVACR------NIGFLAYFCIMLSFV---FLAICSLDFLLKFKQ 305
            |::....|::   :.....||...|.      :..||:.||.:|:..   :||:..     :.:.
Human   975 SILASNILIL---VGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIG-----RMRT 1031

  Fly   306 KAVRSSVRRLSLALAVLAV-IGLRFLVSLAQDSKLPKHFKPGMG-EDYCWFDVRTWGILIYYYGP 368
            :.||.....|...|..|.| :.:.|..:            .|.| ..|||..:. .|:|..:.||
Human  1032 RLVRKRFLCLGWGLPALVVAVSVGFTRT------------KGYGTSSYCWLSLE-GGLLYAFVGP 1083

  Fly   369 IALLLIFSIV 378
            .|::::.:::
Human  1084 AAVIVLVNML 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl9	NP_612029.1	Methuselah_N	29..199	CDD:429053	8/37 (22%)
		7tmB3_Methuselah-like	232..473	CDD:410632	32/158 (20%)
		TM helix 2	241..263	CDD:410632	3/21 (14%)
		TM helix 3	275..302	CDD:410632	7/35 (20%)
		TM helix 4	314..334	CDD:410632	5/20 (25%)
		TM helix 5	358..387	CDD:410632	5/21 (24%)
		TM helix 6	404..431	CDD:410632
		TM helix 7	440..465	CDD:410632
ADGRB2	NP_001351786.1	AGRB_N	38..230	CDD:465991
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	229..271
		TSP1	314..362	CDD:214559
		TSP1	367..417	CDD:214559
		TSP1	422..472	CDD:214559
		TSP1	478..528	CDD:214559
		HormR	531..595	CDD:214468
		GAIN	614..>769	CDD:465137
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	767..806
		GPS	870..923	CDD:197639	8/54 (15%)
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	874..924		6/51 (12%)
		7tmB2_BAI2	929..1219	CDD:320654	39/197 (20%)
		TM helix 1	931..956	CDD:320654	5/24 (21%)
		TM helix 2	966..988	CDD:320654	3/24 (13%)
		TM helix 3	997..1025	CDD:320654	6/27 (22%)
		TM helix 4	1035..1055	CDD:320654	5/19 (26%)
		TM helix 5	1073..1102	CDD:320654	5/22 (23%)
		TM helix 6	1149..1176	CDD:320654
		TM helix 7	1181..1206	CDD:320654
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1359..1385
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1423..1454
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1498..1585