Protein Alignment mthl9 and mthl8

DIOPT Version :10

• Sequence 1: NP_612029.1
• Gene: mthl9 / 38056
• FlyBaseID: FBgn0035131
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_611998.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Alignment Length: 460
• Identity: 140/460 - (30%)
• Similarity: 215/460 - (46%)
• Gaps: 29/460 - (6%)

  Fly    26 NHPCAYAHTVNITDGLRMKDGSYSYAGVVVPPHLMAEYSFKVIDGVEYRAKKHLRGCVCLLKPCI 90
            ::|||:..|.|||....: ||.:.:...|:|.|.:|.|.|.:.:|:...|.:|||.|||..|||:
  Fly    27 HYPCAFIDTANITGSYGL-DGPFVHNWTVIPRHFVAVYDFVIENGIRIPASRHLRACVCKTKPCV 90

  Fly    91 SFCCPENLVFDAKHWNCTMP----HQVRESTHVELTYANRTVDQVRIRDRFVVRTELGCRNKFVD 151
            ..||....::|.:...|.:|    ..:...:|:|:...|.::..|:::.||.:..|..|.:....
  Fly    91 RICCLRGEIYDLEKRQCLVPVAGVSSLPSHSHMEVELGNGSLRLVKLQPRFSIHVETPCEHMKAV 155

  Fly   152 KKHDNFWQWDLFENGTLRRDNRLWSTDEYCFSPLEHNPEQWELTPLNC--ER--FQTGYRVWIYA 212
            .|...:..|.|.||||:.....::| ..|||:||.|....||..||.|  |:  |..|.|.|.||
  Fly   156 TKGSEYVHWTLHENGTISHRGHIFS-KHYCFTPLLHGNSTWEWQPLACAPEKLYFVLGVREWTYA 219

  Fly   213 ICSIIAIIINIFILSLLGSVRDARKSHYGQLIIYYLLSMIVGYSLLVYLALKNPMKLSHVACRNI 277
            ||.:|||:....:|.:.....:.|.|.||..|..|.:.||:||:||.||.|.||..||:.|||.:
  Fly   220 ICLLIAILSMFIVLMVYLMCSEMRNSFYGVAIKAYAICMILGYALLAYLTLHNPANLSNAACRIL 284

  Fly   278 GFLAYFCIMLSFVFLAICSLDFLLKFKQKAVRSSVRRLSLALAVLAVIGLRFLVSLA-QDSKLPK 341
            ..||...::|||..|:..:....|.|........:..|.....||..:|..|.|..: ..|:|.
  Fly   285 PSLALMNLVLSFYILSFIAFKLYLSFYGVVFTKLMFWLIFTPIVLVAVGWSFFVGFSYYGSRLI- 348

  Fly   342 HFKPGMGEDYCWFDVRTWGILIYYYGPIALLLIFSIVCCLKAYFSIYEL-----PPDTQYILGTQ 401
                 .|.|.||||.|.|.::||:|.|:      .:.|.:..:|.:...     .||.:.....:
  Fly   349 -----FGGDTCWFDPRNWSVMIYFYAPV------FVACAISGFFYVLSQIYIRDQPDIETEKSFE 402

  Fly   402 LKIVKTHFYAFSAYIVGVFAVWIREIVVYIMARVREHFFIIDFWSGICILGLAIAGFILLLGKNL 466
             .|.|..|.:|..|......||:..|..:......|:...:::....|:.....|....|:|||.
  Fly   403 -SIEKNRFKSFWKYFGYTAVVWVVCICSFAFNYYWENRSHLNYAVSFCMAFHGFAALYALIGKNQ 466

  Fly   467 HVKSW 471
            .::::
  Fly   467 QIQNF 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl9	NP_612029.1	Methuselah_N	29..199	CDD:429053	56/173 (32%)
		7tmB3_Methuselah-like	232..473	CDD:410632	69/246 (28%)
		TM helix 2	241..263	CDD:410632	11/21 (52%)
		TM helix 3	275..302	CDD:410632	7/26 (27%)
		TM helix 4	314..334	CDD:410632	6/19 (32%)
		TM helix 5	358..387	CDD:410632	7/28 (25%)
		TM helix 6	404..431	CDD:410632	8/26 (31%)
		TM helix 7	440..465	CDD:410632	4/24 (17%)
mthl8	NP_611998.1	Methuselah_N	30..202	CDD:429053	56/173 (32%)
		7tm_GPCRs	213..475	CDD:475119	79/272 (29%)
		TM helix 1	214..238	CDD:410628	10/23 (43%)
		TM helix 2	248..269	CDD:410628	10/20 (50%)
		TM helix 5	360..383	CDD:410628	7/28 (25%)
		TM helix 6	409..431	CDD:410628	6/21 (29%)
		TM helix 7	434..465	CDD:410628	5/30 (17%)