DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl9 and ADGRL2

DIOPT Version :10

Sequence 1:NP_612029.1 Gene:mthl9 / 38056 FlyBaseID:FBgn0035131 Length:513 Species:Drosophila melanogaster
Sequence 2:NP_001352934.1 Gene:ADGRL2 / 23266 HGNCID:18582 Length:1469 Species:Homo sapiens


Alignment Length:274 Identity:49/274 - (17%)
Similarity:102/274 - (37%) Gaps:69/274 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 WIYAICSIIAIIINIFILSLLGSVRDARKSHYGQLIIYYLLS---MIVGYSLLVYLALKNPMKLS 270
            |:..:.|::.:.|.||.......::..|.:.:..|.|...::   .::|.....|.         
Human   856 WVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYA--------- 911

  Fly   271 HVACRNIGFLAYFCIMLSFVFLAICSLDFLLK----FKQKAVRSSVRRLSLALAVLAVIGLRFLV 331
             :||.....|.:|..:.:|.::.:..:...|.    |:.:..|.....::..|....|:|    |
Human   912 -IACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLFPATVVG----V 971

  Fly   332 SLAQDSKLPKHFKPGMGEDYCWFDVRTWGILIYYYGPIALL----LIFSIVCCLKAYFSIYELPP 392
            |.|.|      :|....|..||..|..: .:..:.||:..:    :||.::...|.......|.|
Human   972 SAAID------YKSYGTEKACWLHVDNY-FIWSFIGPVTFIILLNIIFLVITLCKMVKHSNTLKP 1029

  Fly   393 DTQYILGTQLKIVKTHFYAFSAYIVGVFAVWIREIVVYIMARVREHFFIIDFWSGICILGLAIAG 457
            |:     ::|:.:|       ::::|.||:                         :|:|||..:.
Human  1030 DS-----SRLENIK-------SWVLGAFAL-------------------------LCLLGLTWSF 1057

  Fly   458 FILLLGKNLHVKSW 471
            .:|.:.:...|.::
Human  1058 GLLFINEETIVMAY 1071

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl9NP_612029.1 Methuselah_N 29..199 CDD:429053
7tmB3_Methuselah-like 232..473 CDD:410632 44/251 (18%)
TM helix 2 241..263 CDD:410632 4/24 (17%)
TM helix 3 275..302 CDD:410632 3/26 (12%)
TM helix 4 314..334 CDD:410632 5/19 (26%)
TM helix 5 358..387 CDD:410632 5/32 (16%)
TM helix 6 404..431 CDD:410632 4/26 (15%)
TM helix 7 440..465 CDD:410632 5/24 (21%)
ADGRL2NP_001352934.1 Gal_Rha_Lectin_LPHN2 36..132 CDD:438702
OLF 142..398 CDD:470611
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 426..460
HormR 469..533 CDD:214468
GAIN 542..764 CDD:465137
GPS 788..840 CDD:197639
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 792..841
7tmB2_Latrophilin-2 848..1105 CDD:320672 49/274 (18%)
TM helix 1 850..875 CDD:320672 5/18 (28%)
TM helix 2 884..906 CDD:320672 3/21 (14%)
TM helix 3 915..942 CDD:320672 3/26 (12%)
TM helix 4 954..974 CDD:320672 5/23 (22%)
TM helix 5 991..1020 CDD:320672 4/29 (14%)
TM helix 6 1036..1063 CDD:320672 9/58 (16%)
TM helix 7 1067..1092 CDD:320672 1/5 (20%)
Latrophilin 1104..1469 CDD:460538
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1368..1410
Blue background indicates that the domain is not in the aligned region.

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