DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atac3 and gabpb2a

DIOPT Version :9

Sequence 1:	NP_001246531.1	Gene:	Atac3 / 38055	FlyBaseID:	FBgn0052343	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_001093447.1	Gene:	gabpb2a / 554849	ZFINID:	ZDB-GENE-030131-5733	Length:	407	Species:	Danio rerio

Alignment Length:	428	Identity:	118/428 - (27%)
Similarity:	189/428 - (44%)	Gaps:	106/428 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VDLGKQLLQCARDSDVAGVKAALAHGAPFASDWLGMSALHFAAMNNQLEICEILLQGGINMDGKT 116
            |||||:||:.||:.....|:..:|:||||.:||||.|.||.||.:......|:||:.|::.|.:|
Zfish     4 VDLGKRLLEAARNGHDDEVRTLMANGAPFTTDWLGTSPLHLAAQHGHYSTAEVLLRAGVSRDART 68

  Fly   117 KVDRTPLHLACYYGHERIVSLLLALKCSVNSRDMLRMTPLHWAVEKKHKGIVRLLLKCQADVTLV 181
            ||||||||:|...|||.||.||:.....:|::|||:||.||||.:..|..:..||:|..|||..:
Zfish    69 KVDRTPLHMAATEGHEVIVDLLIRSGADINAKDMLKMTALHWAAQHGHHNVAELLIKHGADVHAL 133

  Fly   182 SKFGKTPIGLAVYTEQADVLAELEAARQAQASKKLHEESEQQAHKTKKETNEAVSSIMD---EPE 243
            |||.||...:||..:..|::..|:...:.|.::                  .|.:||::   .|:
Zfish   134 SKFCKTAFDIAVDIQHPDLMHLLQEGMENQVNR------------------NAEASIINGSSTPQ 180

  Fly   244 VIKTVDDKEMSVEERMDVLENMRGHANVLRNTALYILKTHEIADMVQDNDDEDSKEMLNTALQNG 308
            .|                   ::|..|:.....       .:.|:::.|..:..:.:..:||.:.
Zfish   181 FI-------------------IQGVPNIQGGVV-------NLTDLIKTNSGDTEEAIAVSALDSS 219

  Fly   309 RQLVLSEGGRMLL------HETKSGISGKQSTNGNARP---------SVAALRTNVNNSHPKIRM 358
            .|.|::|.|:.::      |       |...|||..:|         .|.|:..|      :|..
Zfish   220 IQQVVNESGQRVITILTDQH-------GNLQTNGLGQPFFVTMQDGRQVLAVPAN------QITE 271

  Fly   359 NVLKQKDLPSPAGVAKNKNIRIISLTDFKKLYGSDSTAKSLQKIPASLASSGMVRHLPDGTKLVN 423
            .|:::.:.|     |:.:.|.:          .|::|            .:|...||....:..|
Zfish   272 EVVEESEPP-----ARKRKIEV----------ASNNT------------ETGETEHLQWQLQEAN 309

  Fly   424 MRQLQARQLKLPSLQRPQD----LTALEESHSQNEAAV 457
            .:....||..|...|..::    |.|:|...|...||:
Zfish   310 RKAQSYRQQLLRKEQEAEEYRMKLEAMENGQSNGTAAL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atac3	NP_001246531.1	Ank_4	58..106	CDD:290365	20/47 (43%)
		ANK repeat	58..83	CDD:293786	10/24 (42%)
		ANK	81..204	CDD:238125	56/122 (46%)
		ANK repeat	88..116	CDD:293786	10/27 (37%)
		Ank_2	90..181	CDD:289560	43/90 (48%)
		ANK repeat	118..149	CDD:293786	16/30 (53%)
		ANK repeat	151..181	CDD:293786	14/29 (48%)
		ANK repeat	184..211	CDD:293786	7/26 (27%)
gabpb2a	NP_001093447.1	Ank_4	10..58	CDD:290365	20/47 (43%)
		ANK repeat	10..35	CDD:293786	10/24 (42%)
		ANK	34..156	CDD:238125	56/121 (46%)
		ANK repeat	38..68	CDD:293786	11/29 (38%)
		Ank_2	42..132	CDD:289560	43/89 (48%)
		ANK repeat	70..101	CDD:293786	16/30 (53%)
		ANK repeat	103..132	CDD:293786	14/28 (50%)
		ANK repeat	136..169	CDD:293786	8/50 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1514706at2759
OrthoFinder	1	1.000	-	-		FOG0002988
OrthoInspector	1	1.000	-	-		otm24325
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24193
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5776
SonicParanoid	1	1.000	-	-		X1982
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	8.010