DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atac3 and Gabpb2

DIOPT Version :9

Sequence 1:	NP_001246531.1	Gene:	Atac3 / 38055	FlyBaseID:	FBgn0052343	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	XP_006232998.1	Gene:	Gabpb2 / 295263	RGDID:	1565234	Length:	413	Species:	Rattus norvegicus

Alignment Length:	428	Identity:	117/428 - (27%)
Similarity:	177/428 - (41%)	Gaps:	90/428 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VDLGKQLLQCARDSDVAGVKAALAHGAPFASDWLGMSALHFAAMNNQLEICEILLQGGINMDGKT 116
            |||||:||:.||......|:..:|:||||.:||||.|.||.||........|:||:.|::.|.:|
  Rat     4 VDLGKRLLEAARKGQDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDART 68

  Fly   117 KVDRTPLHLACYYGHERIVSLLLALKCSVNSRDMLRMTPLHWAVEKKHKGIVRLLLKCQADVTLV 181
            ||||||||:|...||..||.||:.....||::|||:||.||||.|.:|:.:|.||:|..|||...
  Rat    69 KVDRTPLHMAAADGHAHIVELLVRSGADVNAKDMLQMTALHWATEHRHRDVVELLIKYGADVHAF 133

  Fly   182 SKFGKTPIGLAVYTEQADVLAELEAARQAQASKKLHEESEQQAHKTKKETNEAVSSIMDEPEVIK 246
            |||.|:...:|:.....::|..|:.|.|.|.:     .:.::|:............|....||:
  Rat   134 SKFDKSAFDIALEKNNTEILVMLQEAMQNQVN-----TNPERANPVANPVAVTAPFIFTSGEVV- 192

  Fly   247 TVDDKEMSVEERMDVLENMRGHANVLRNTALYILKTHEIADMVQDNDDEDSKEMLNTALQNGRQL 311
                             |:....:...||........||.:              ..:|.:..|.
  Rat   193 -----------------NLASFVSSANNTKATSANLEEIEE--------------GNSLDSSIQQ 226

  Fly   312 VLSEGGRMLLHETKSG-----ISGKQSTNGNARPSVAALRTNVNNSHPKIRMNVLKQKDLPSPAG 371
            |:..||:.::.....|     |.....|.|..:|.:..::..              |..|..|||
  Rat   227 VVGSGGQRVITIVTDGVPLGNIQTAIPTGGIGQPFIVTMQDG--------------QPVLTVPAG 277

  Fly   372 VAKNKNIRIISLTDFKKLYGSDSTAKSLQKIPASLASSGMVRHLPDGTK---------------- 420
            ....:.|......|.:||        .|.|.|.....:..|..:.:|::
  Rat   278 QVAEETIIEEEEEDEEKL--------PLVKRPRMAEMTNSVEEMKEGSERELLQQQLQEANRRAQ 334

  Fly   421 ------LVNMRQLQARQLKLPSLQRPQ----DLTALEE 448
                  |...::.:..:|:|.::.|.|    |.|.:||
  Rat   335 EYRHQLLKKEQEAEQYRLRLEAMARQQPNGVDFTVVEE 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atac3	NP_001246531.1	Ank_4	58..106	CDD:290365	20/47 (43%)
		ANK repeat	58..83	CDD:293786	10/24 (42%)
		ANK	81..204	CDD:238125	56/122 (46%)
		ANK repeat	88..116	CDD:293786	10/27 (37%)
		Ank_2	90..181	CDD:289560	45/90 (50%)
		ANK repeat	118..149	CDD:293786	16/30 (53%)
		ANK repeat	151..181	CDD:293786	16/29 (55%)
		ANK repeat	184..211	CDD:293786	7/26 (27%)
Gabpb2	XP_006232998.1	Ank_4	10..58	CDD:290365	20/47 (43%)
		ANK repeat	10..35	CDD:293786	10/24 (42%)
		ANK	34..156	CDD:238125	56/121 (46%)
		ANK repeat	38..68	CDD:293786	11/29 (38%)
		Ank_2	42..132	CDD:289560	45/89 (51%)
		ANK repeat	70..101	CDD:293786	16/30 (53%)
		ANK repeat	103..132	CDD:293786	16/28 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1514706at2759
OrthoFinder	1	1.000	-	-		FOG0002988
OrthoInspector	1	1.000	-	-		otm46265
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24193
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1982
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.910