Protein Alignment Atac3 and GABPB1

DIOPT Version :9

• Sequence 1: NP_001246531.1
• Gene: Atac3 / 38055
• FlyBaseID: FBgn0052343
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: XP_024305651.1
• Gene: GABPB1 / 2553
• HGNCID: 4074
• Length: 400
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 135/532 - (25%)
• Similarity: 204/532 - (38%)
• Gaps: 166/532 - (31%)

  Fly    52 VDLGKQLLQCARDSDVAGVKAALAHGAPFASDWLGMSALHFAAMNNQLEICEILLQGGINMDGKT 116
            |||||:||:.||......|:..:|:||||.:||||.|.||.||........|:||:.|::.|.:|
Human     9 VDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 73

  Fly   117 KVDRTPLHLACYYGHERIVSLLLALKCSVNSRDMLRMTPLHWAVEKKHKGIVRLLLKCQADVTLV 181
            ||||||||:|...||..||.:||.....||::|||:||.||||.|..|:.:|.||:|..|||...
Human    74 KVDRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQ 138

  Fly   182 SKFGKTPIGLAVYTEQADVLAELEAARQAQASKKLHEESEQQAHKTKKETNEAVSSIMDEPEVIK 246
            |||.||...:::.....|:...|:.|.|.|.:             |..|:.:.|:.....|:.|
Human   139 SKFCKTAFDISIDNGNEDLAEILQIAMQNQIN-------------TNPESPDTVTIHAATPQFI- 189

  Fly   247 TVDDKEMSVEERMDVLENMRGHANVLRNTALYILKTHEIADMVQDNDDEDSKEMLNTALQNGRQL 311
                               .|...|:..|.                                  |
Human   190 -------------------IGPGGVVNLTG----------------------------------L 201

  Fly   312 VLSEGGRMLLHETKSGISGKQSTNGNARPSVAALRTNVNNSHPKIRMNVLKQKDLPSPAGVAKNK 376
            |.||.......||  |:|..|.  ||:..||.|            .:..|.:...|    ::.:.
Human   202 VSSENSSKATDET--GVSAVQF--GNSSTSVLA------------TLAALAEASAP----LSNSS 246

  Fly   377 NIRIISLTDFKKLYGSDSTAKSLQKIPASLASSG---MVRHLPDGTKLVNMRQLQARQLKLPSLQ 438
            ...:::..:.       .||:|:......:.|||   ::..:.||.:|.|:
Human   247 ETPVVATEEV-------VTAESVDGAIQQVVSSGGQQVITIVTDGIQLGNL-------------- 290

  Fly   439 RPQDLTALEESHSQNEAAVPSP----LPSGHPASGSSLRGQVGTVQTIQLRPSLSAGSGQGAVNN 499
                       ||...:.:..|    :|.|.         ||.||
Human   291 -----------HSIPTSGIGQPIIVTMPDGQ---------QVLTV-------------------- 315

  Fly   500 GAAPGKTIVNATKQSPKSPNVMPLLTSSEICRQLHELRRQNEDLRRRADSFQREKEEMLRRIDRL 564
               |...|...|..|.:.|       :...|.::.|.|.::.::..| ::.|::.:|..|...:.
Human   316 ---PATDIAEETVISEEPP-------AKRQCIEIIENRVESAEIEER-EALQKQLDEANREAQKY 369

  Fly   565 EQMVLVQESEAD 576
            .|.:|.:|.||:
Human   370 RQQLLKKEQEAE 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atac3	NP_001246531.1	Ank_4	58..106	CDD:290365	20/47 (43%)
		ANK repeat	58..83	CDD:293786	10/24 (42%)
		ANK	81..204	CDD:238125	56/122 (46%)
		ANK repeat	88..116	CDD:293786	10/27 (37%)
		Ank_2	90..181	CDD:289560	45/90 (50%)
		ANK repeat	118..149	CDD:293786	16/30 (53%)
		ANK repeat	151..181	CDD:293786	16/29 (55%)
		ANK repeat	184..211	CDD:293786	7/26 (27%)
GABPB1	XP_024305651.1	ANK repeat	15..40	CDD:293786	10/24 (42%)
		ANK	39..161	CDD:238125	56/121 (46%)
		ANK repeat	43..73	CDD:293786	11/29 (38%)
		ANK repeat	75..106	CDD:293786	16/30 (53%)
		ANK repeat	108..138	CDD:293786	16/29 (55%)
		ERM	<328..>394	CDD:330563	13/62 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4175
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1514706at2759
OrthoFinder	1	1.000	-	-		FOG0002988
OrthoInspector	1	1.000	-	-		otm42119
orthoMCL	1	0.900	-	-		OOG6_107779
Panther	1	1.100	-	-	O	PTHR24193
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5776
SonicParanoid	1	1.000	-	-		X1982
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.860