Protein Alignment Atac3 and ANKRD35

DIOPT Version :10

• Sequence 1: NP_001246531.1
• Gene: Atac3 / 38055
• FlyBaseID: FBgn0052343
• Length: 583
• Species: Drosophila melanogaster
• Sequence 2: NP_653299.4
• Gene: ANKRD35 / 148741
• HGNCID: 26323
• Length: 1001
• Species: Homo sapiens
• Alignment Length: 648
• Identity: 153/648 - (23%)
• Similarity: 244/648 - (37%)
• Gaps: 153/648 - (23%)

  Fly    56 KQLLQCARDSDVAGVKAALAHGAPFAS---DWLGMSALHFAAMNNQLEICEILLQGGINMDGKTK 117
            |.|.:|        :...||:||...|   |  |.:|||.|.::.|.:..::|||.|.|.|....
Human    64 KGLTEC--------LTILLANGADINSKNED--GSTALHLATISCQPQCVKVLLQHGANEDAVDA 118

  Fly   118 VDRTPLH------------LACYY---------------------GHERIVSLLLALKCSVNSRD 149
            .:|:|||            |.|.:                     ||..|.|.||.....||..|
Human   119 ENRSPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGGHAAICSQLLQRGARVNVTD 183

  Fly   150 MLRMTPLHWAVEKKHKGIVRLLLKCQADVTLVSKFGKTPIGLAVYTEQADVLAELEAA--RQAQA 212
            ....:.|..|.||....:..|||...||...|...|...:..|::|:...:...|:.|  |:.:.
Human   184 KNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALHYALHTQDKALWRHLQQALSRRRRG 248

  Fly   213 SKKL--HEESEQQAHKTKKET-NEAVSSIMDEPEVIKTVDDKE----MSVEERMDVLENMRGHAN 270
            .::|  |.:...||..::.:. :...||...|||  :..::||    .|.|.|....|..|   .
Human   249 GQRLVQHPDLASQASPSEPQAGSPPKSSWRAEPE--EEQEEKEDEDPCSEEWRWKYEEERR---K 308

  Fly   271 VLRNTALYILKTHE-----IADMVQDNDDEDSKEMLNTALQ-----NGRQ-LVLSEGG------- 317
            |:|.....:.||.|     .|.:..:|...:..:.|...|.     :|:| ..|..||
Human   309 VVRLEQELVQKTEECKTQAAAYLDLENQIREQAQELGVLLSWEPRASGKQGSSLRPGGDGMEQGC 373

  Fly   318 -RMLLHETKSGISGKQSTNGNARPSVAALRTNVNNSHP-KIRMNV--LKQKDLPSPAGVAKNKNI 378
             :.||.|:...:..:|.......|.:|..:  ..:|.| ||:..|  ..|.:...|.....::.|
Human   374 PKDLLAESTQELKKQQQAAATVNPVLAPKK--AEDSAPGKIQYEVHGRSQPEEQGPPQSPASETI 436

  Fly   379 RIIS----LTDFKKLYGSDSTAKSLQKIPASLASSGMVRHL--------PDGTKLVNMRQLQARQ 431
            |..:    .|:..:.:|.|..    .::||....|..|..:        |.|...:|...||.|:
Human   437 RKATGQQLTTNGAQTFGPDHA----DQLPAGQKESSQVLGVEPGGTVAEPVGPAAMNQLLLQLRE 497

  Fly   432 LKLPSLQRPQDLTALEESHSQNEAAVPSPLPSGHPASGSSLRGQVGTVQT--------IQLRPSL 488
             :|.::.|.:|......|....|.|:.:|......|:...:..::..|..        :|::|.:
Human   498 -ELAAVWREKDAARGALSRPVMEGALGTPRAEAAAAAWEKMEARLERVLARLEWAKAGLQVKPEV 561

  Fly   489 -SAGSGQGAVNNGAAPGKTIVNATKQSPKSPNVM--PL-------------------------LT 525
             |..|.:||:.  |||| :|....::..:.|...  ||                         |:
Human   562 PSQESREGALK--AAPG-SIKQDEEKEKRVPGAQGEPLGALGGEKALGGLAKGQLEKEMSVLRLS 623

  Fly   526 SSEICRQLHELRRQNEDLRRRADS----FQRE---KEEMLRRIDRLEQMV------LVQESEA 575
            :|.:..:|.||.|:.:.|:|...|    .|||   |.:...::.:|.|.|      |..|.||
Human   624 NSNLLEELGELGRERQRLQRELQSLSQRLQREFVPKPQAQVQLQQLRQSVGLLTNELAMEKEA 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atac3	NP_001246531.1	ANKYR	<58..251	CDD:440430	60/233 (26%)
		ANK repeat	58..83	CDD:293786	7/27 (26%)
		ANK repeat	88..116	CDD:293786	11/27 (41%)
		ANK repeat	118..149	CDD:293786	14/63 (22%)
		ANK repeat	151..181	CDD:293786	9/29 (31%)
		ANK repeat	184..211	CDD:293786	6/28 (21%)
ANKRD35	NP_653299.4	ANKYR	24..242	CDD:440430	50/187 (27%)
		ANK repeat	24..51	CDD:293786
		ANK repeat	53..84	CDD:293786	8/27 (30%)
		ANK 1	53..82		7/25 (28%)
		ANK repeat	86..117	CDD:293786	13/32 (41%)
		ANK 2	86..115		12/30 (40%)
		ANK repeat	119..150	CDD:293786	6/30 (20%)
		ANK 3	119..148		6/28 (21%)
		ANK repeat	152..183	CDD:293786	8/30 (27%)
		ANK 4	152..181		7/28 (25%)
		ANK repeat	185..216	CDD:293786	9/30 (30%)
		ANK 5	185..214		9/28 (32%)
		ANK 6	218..247		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..296		9/41 (22%)
		SMC_prok_B	<301..>960	CDD:274008	87/399 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..482		27/135 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	559..601		13/44 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	879..902