DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and VAV1

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:NP_005419.2 Gene:VAV1 / 7409 HGNCID:12657 Length:845 Species:Homo sapiens


Alignment Length:581 Identity:121/581 - (20%)
Similarity:203/581 - (34%) Gaps:166/581 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  2848 ESYGMGRPDLEDSDSDSVASNEEAISFYPT-TYAEVLYNFTAGGPQELGLERGMLIEILRKEVGP 2911
            |.:|:.|.:|           .||...:.. .:.:|:|..:|.....:...||::         |
Human    84 EKFGLKRSEL-----------FEAFDLFDVQDFGKVIYTLSALSWTPIAQNRGIM---------P 128

  Fly  2912 WWFGRIKKEETNLVEDI---LGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAE 2973
            :    ..:||:...|||   |..::....:|...:..|.|.:      .|..||  ..|...|:|
Human   129 F----PTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENE------EAEGDE--IYEDLMRSE 181

  Fly  2974 EGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDT 3038
            ..|:|..:..:.:                                         |...:||:..|
Human   182 PVSMPPKMTEYDK-----------------------------------------RCCCLREIQQT 205

  Fly  3039 EVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQNQVA--- 3100
            |..|...|.:|...:|..:.:   ...|..|.:||.||..:.:....||:.::..:.....|   
Human   206 EEKYTDTLGSIQQHFLKPLQR---FLKPQDIEIIFINIEDLLRVHTHFLKEMKEALGTPGAANLY 267

  Fly  3101 KVFLKMHKGFLCYSTYCNAYPRALIELETYDRV----KDARTILENCRESQNLAELPLSAHLLAP 3161
            :||:|..:.||.|..||:....|...|   |||    :|.:..||.|.:..|.....|...|:.|
Human   268 QVFIKYKERFLVYGRYCSQVESASKHL---DRVAAAREDVQMKLEECSQRANNGRFTLRDLLMVP 329

  Fly  3162 VQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAM 3226
            :||:.:|.|.|.|::|...|...||                               .:.|||:||
Human   330 MQRVLKYHLLLQELVKHTQEAMEKE-------------------------------NLRLALDAM 363

  Fly  3227 RGITEAVNEGKRHSET---IARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYTLFLF 3288
            |.:.:.|||.||.:||   |...|.|.:|......|....:...::..|..::......|. ||.
Human   364 RDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRSKMDRYA-FLL 427

  Fly  3289 DNQLVYCKR--------DIIKRSHFIYKGRIFLDRCRVVNVRDGKMFGHTIKNSLRIYSESRDKW 3345
            |..|:.|||        |.:....|..:.....|       ||.|.:.|    ...:..:...:.
Human   428 DKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGD-------RDNKKWSH----MFLLIEDQGAQG 481

  Fly  3346 YDFSFRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFEL 3406
            |:..|::...|.:::      .||   .:.:|.:             |.:.:..:..||::
Human   482 YELFFKTRELKKKWM------EQF---EMAISNI-------------YPENATANGHDFQM 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620 13/69 (19%)
RhoGEF 3031..3235 CDD:279015 55/210 (26%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 28/143 (20%)
PH <3285..3363 CDD:278594 17/85 (20%)
VAV1NP_005419.2 CH_VAV1 2..121 CDD:409111 9/47 (19%)
RhoGEF 195..371 CDD:238091 55/212 (26%)
PH_Vav 385..508 CDD:269930 26/156 (17%)
C1_VAV1 510..566 CDD:410417 2/11 (18%)
SH3_VAV1_1 596..658 CDD:212912
SH2_Vav1 665..767 CDD:198268
SH3_VAV1_2 786..839 CDD:212909
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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