Protein Alignment RhoGEF3 and Pex13

DIOPT Version :9

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: NP_076140.2
• Gene: Pex13 / 72129
• MGIID: 1919379
• Length: 405
• Species: Mus musculus
• Alignment Length: 500
• Identity: 94/500 - (18%)
• Similarity: 161/500 - (32%)
• Gaps: 166/500 - (33%)

  Fly  2564 KPNKSRRTGRSRSLPSVMLRRLYLAGMPKPGSNEMGT--TSDCAASLSQQIKAVSSPTLSE--PC 2624
            ||.:|||      :|.        || |.|||....|  ::|...:|   :.....|||:.  |.
Mouse    10 KPWESRR------IPG--------AG-PGPGSGPGPTYQSADLGPTL---LTRPGQPTLTRVPPP 56

  Fly  2625 LEEQPQKGTESTDV-----ANTGSSAGSGGLGVLQKFKRTLNNFNNK-------------NQLHI 2671
            :..:|.:.|.|.:|     |.:..|:|.|..|         |:|...             |:|.:
Mouse    57 ILPRPSQQTGSNNVNTFRPAYSSFSSGYGAYG---------NSFYGSYSPYSYGYNGLGFNRLRV 112

  Fly  2672 SPLSPAAVGNNAPKTK-------TSPTTTTASIAPMITTTTASDPGS------EAGDTSSGKYRF 2723
            ..|.|:.....|.::.       .|.....||::.|:..|.::...|      .|...|..|..|
Mouse   113 DDLPPSRFVQQAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHF 177

  Fly  2724 GPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQY--SRATMA-VSRQDEPRAFALTNGSC 2785
            ..:....:..|......||.:..   .|::...|.::.:  |..|:| :|.:|:
Mouse   178 TKVFSAFALVRTIRYLYRRLQWM---MGLRRGSENEDLWAESEGTVACLSAEDQ----------- 228

  Fly  2786 GVALSKMRAIRRTNSAKASSIL--------GPFIVKTKIAKHLNIGESDKAERKAPESLPTRSLS 2842
                       .|||||:..|.        ||:::...::.|.:
Mouse   229 -----------ATNSAKSWPIFLFFAVILGGPYLIWKLLSTHND--------------------- 261

  Fly  2843 QPNGLESYGMGRPDLEDSDSDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRK 2907
                           |.:|:.:.||.|:     ....|...|:|.|...:|:....|.::.:..|
Mouse   262 ---------------EVTDNTNWASGED-----DHVVARAEYDFVAVSDEEISFRAGDMLNLALK 306

  Fly  2908 EVGP----WWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEA 2968
            |..|    |           |:..:.|...|..|..:|:|:            .........|.:
Mouse   307 EQQPKVRGW-----------LLASLDGQTTGLIPANYVKIL------------GKRRGRKTIESS 348

  Fly  2969 TARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAP 3013
            |...::.|...|.......|...:...::....:.:|:....|||
Mouse   349 TMLKQQQSFTNPTLIKGVTTTNPLDEQEAAFESVFVETNKVSSAP 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620	14/69 (20%)
		RhoGEF	3031..3235	CDD:279015
		PH_Collybistin_ASEF	3240..3373	CDD:269931
		PH	<3285..3363	CDD:278594
Pex13	NP_076140.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		22/78 (28%)
		Peroxin-13_N	113..256	CDD:282008	31/167 (19%)
		SH3_PEX13_eumet	278..335	CDD:212798	15/67 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030