Protein Alignment RhoGEF3 and Arhgef9

DIOPT Version :10

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: XP_038955963.1
• Gene: Arhgef9 / 66013
• RGDID: 620719
• Length: 523
• Species: Rattus norvegicus
• Alignment Length: 611
• Identity: 161/611 - (26%)
• Similarity: 256/611 - (41%)
• Gaps: 151/611 - (24%)

  Fly  2863 DSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVED 2927
            ||:.|            ||.:::......:||..:.|.:|::|......||:|:|..||
  Rat    15 DSIVS------------AEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEE------ 61

  Fly  2928 ILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVTV 2992
                  ||||..|||:              ....|...||..:..:.|.:
  Rat    62 ------GWFPASFVRL--------------WVNQEDGVEEGPSDVQNGHL--------------- 91

  Fly  2993 TTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAM 3057
               ..|...:.:..|          :...|.   :|.:.:.|::.||.:|:|.|..||:|||...
  Rat    92 ---DPNSDCLCLGRP----------LQNRDQ---MRANVINEIMSTERHYIKHLKDICEGYLKQC 140

  Fly  3058 SKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQ-----NQVAKVFLKMHKGFLCYSTYC 3117
            .||.|:||...:::||.||..||:||..|:..|.:....     :::...||:...||..||.||
  Rat   141 RKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYC 205

  Fly  3118 NAYPRALIELETYDRVKDAR--TILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSAL 3180
            |.:..|.:||...  :||:|  ...|.||..|.:.::.:...||.|||:||:|||.|.|::|
  Rat   206 NNHLDACMELSKL--MKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLK--- 265

  Fly  3181 EKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSET--- 3242
                         .:|...:||..              |..||..||.:|:.:||.||..|.
  Rat   266 -------------YTAQDHSDYRY--------------VAAALAVMRNVTQQINERKRRLENIDK 303

  Fly  3243 IARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLW-------NSSYTLFLFDNQLVYCKRDII 3300
            ||:.|||..:::|..:...|:......:..      |       |.....||||:|:|.||:|:|
  Rat   304 IAQWQASVLDWEGDDILDRSSELIYTGEMA------WIYQPYGRNQQRVFFLFDHQMVLCKKDLI 362

  Fly  3301 KRSHFIYKGRIFLDRCRVVNVRDGK--MFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTL 3363
            :|....|||||.:|:..|:::.||:  .|..::||:.:::::..::.:.|..:....|.|:|...
  Rat   363 RRDILYYKGRIDMDKYEVIDIEDGRDDDFNVSMKNAFKLHNKETEEVHLFFAKKLEEKIRWLRAF 427

  Fly  3364 ALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAK----- 3423
            ..||    |.:...|..|||.:..::     .|:....:......||.|..|..|..|..
  Rat   428 REER----KMVQEDEKIGFEISENQK-----RQAAMTVRKASKQKGVNSARSVPPSYPPPQDPLN 483

  Fly  3424 ----------STSRLCE-TLPKKSQS 3438
                      :.|::.| |.||:|||
  Rat   484 QGQYLVPDGIAQSQVFEFTEPKRSQS 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	SH3	2876..2942	CDD:214620	18/65 (28%)
		RhoGEF	3028..3234	CDD:238091	68/212 (32%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	39/144 (27%)
Arhgef9	XP_038955963.1	SH3_ARHGEF9	14..75	CDD:212908	23/97 (24%)
		RhoGEF	114..293	CDD:214619	67/210 (32%)
		PH_Collybistin_ASEF	298..437	CDD:269931	40/148 (27%)