DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and PREX1

DIOPT Version :10

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:NP_065871.3 Gene:PREX1 / 57580 HGNCID:32594 Length:1659 Species:Homo sapiens


Alignment Length:408 Identity:108/408 - (26%)
Similarity:179/408 - (43%) Gaps:82/408 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  3008 PTPSAPSVDFVAQP-------------DHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSK 3059
            |.|.||.   .|.|             :....:|...:.|:|.||.:||..|..:...:|..:.:
Human    20 PDPRAPG---AAAPSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQ 81

  Fly  3060 RI-----DIFSPNSIRLIFSNITAIYKFQRKFLEALRRGI-----EQNQVAKVFLKMHKGFLCYS 3114
            .:     ...:..:::::||||..|.:..:.||.||...:     .|:::..||||....|..|.
Human    82 NVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYE 146

  Fly  3115 TYCNAYPRALIELETYDRVKDARTILENCR--ESQNLAELPLSAHLLAPVQRICRYPLHLNEIIK 3177
            .||:.:.:||..|...:::...|..|.:|.  ..:...::||..:||:|:||||:|||.|.|:.|
Human   147 EYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAK 211

  Fly  3178 SALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHS-- 3240
                            ::.||..|:              ..|..||:||:.:...:||.||..  
Human   212 ----------------RTPGKHPDH--------------PAVQSALQAMKTVCSNINETKRQMEK 246

  Fly  3241 -ETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWN-SSYTLFLFDNQLVYCKR------ 3297
             |.:.:.|:..:.::|..|.....:..||  .|..|.:..| .....|||||.||||||      
Human   247 LEALEQLQSHIEGWEGSNLTDICTQLLLQ--GTLLKISAGNIQERAFFLFDNLLVYCKRKSRVTG 309

  Fly  3298 --------DIIKRSHFIYKGRIFLDRCRVVNVRDG----KMFGHTIKNSLRIYSESRDKWYDFSF 3350
                    ..|..|.:|::|||..:...|.||.||    ...|:|:.|..:|::.:::||:....
Human   310 SKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMA 374

  Fly  3351 RSANRKHRFLSTLALERQ 3368
            ::|..|.::|..:..||:
Human   375 KTAEEKQKWLDAIIRERE 392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 SH3 2876..2942 CDD:214620
RhoGEF 3028..3234 CDD:238091 56/217 (26%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 42/151 (28%)
PREX1NP_065871.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 6/22 (27%)
RhoGEF 53..238 CDD:459876 55/214 (26%)
PH_Collybistin_ASEF 244..396 CDD:269931 42/151 (28%)
DEP 414..494 CDD:470580
DEP_2_P-Rex 506..598 CDD:239887
PDZ 635..702 CDD:214570
PDZ_canonical 708..>759 CDD:483948
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 796..819
Blue background indicates that the domain is not in the aligned region.

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