DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF3 and PLEKHG1

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_001316727.1	Gene:	PLEKHG1 / 57480	HGNCID:	20884	Length:	1444	Species:	Homo sapiens

Alignment Length:	717	Identity:	171/717 - (23%)
Similarity:	262/717 - (36%)	Gaps:	208/717 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  2769 VSRQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIGESDKAERKAP 2833
            |.|:.:..| |.||...|.:::....:|....:..:.:..|   ||            .|.|..|
Human     6 VGRKRQETA-AWTNRVLGQSITDGHQLRLEVPSAVTKVPHP---KT------------TARRSCP 54

  Fly  2834 ESLPTRSLSQPNGLESYGMGRPDLEDSDSDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLER 2898
            :.|.|..||..:...|:|        |.|.|.:|.:...||              |....|....
Human    55 QELKTMELSDSDRPVSFG--------STSSSASSRDSHGSF--------------GSRMTLVSNS 97

  Fly  2899 GMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEA 2963
            .|.:....|||     |.||.|        |.|...:...|..|       ||          .|
Human    98 HMGLFNQDKEV-----GAIKLE--------LIPARPFSSSELQR-------DN----------PA 132

  Fly  2964 AAEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIR 3028
            ..::   .|:|||...|.|.:..|::....|        :.:|..:|....||.|
Human   133 TGQQ---NADEGSERPPRAQWRVDSNGAPKT--------IADSATSPKLLYVDRV---------- 176

  Fly  3029 RSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDI-FSPNSIRLIFSNITAIYKFQRKFLEALRR 3092
               |:|:|:||..||:.|.:|.:.||..:..:..: ........:|.||..||.|..:.|:.| .
Human   177 ---VQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDL-E 237

  Fly  3093 GIEQNQV--AKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAE---- 3151
            ..|.:.|  |:.|:...:.|..|:.||..|||::             .:|..|..::.||:
Human   238 NCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSV-------------AVLTECMRNKILAKFFRE 289

  Fly  3152 --------LPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVT 3208
                    |||.::||.|||||.:|.|.|:| |::.|:|      ||:|
Human   290 RQETLKHSLPLGSYLLKPVQRILKYHLLLHE-IENHLDK------DTEG---------------- 331

  Fly  3209 ELDIPDSQDTVNLALEAMRGITEAVNEGKR---HSETIARHQASFQNFKGPPLHLHSARFFLQVD 3270
                   .|.|..|::.|:.:...:|:.||   |:..:...|:...|:|||.|..:..   |.::
Human   332 -------YDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWKGPDLTSYGE---LVLE 386

  Fly  3271 ATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNV-------------R 3322
            .|.:.|...|.. ||||||..|:..|:   :...|.||..|......:|.|             :
Human   387 GTFRIQRAKNER-TLFLFDKLLLITKK---RDDTFTYKAHILCGNLMLVEVIPKEPLSFSVFHYK 447

  Fly  3323 DGKMFGHTIKNSLRIYSESRDK--WYDFSFR----------SANRKHRFLSTLALER-------Q 3368
            :.|: .||::     ....:||  |.....|          .|..|...|...|:..       :
Human   448 NPKL-QHTVQ-----AKSQQDKRLWVLHLKRLILENHAAKIPAKAKQAILEMDAIHHPGFCYSPE 506

  Fly  3369 FGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGV--TSGESSLPE------SPAKST 3425
            .|.|||:.|:.....|.. .|..:.|.:|....:..|.|..:  .|.|...|:      |||:..
Human   507 GGTKALFGSKEGSAPYRL-RRKSEPSSRSHKVLKTSETAQDIQKVSREEGSPQLSSARPSPAQRN 570

  Fly  3426 SR 3427
            |:
Human   571 SQ 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620	13/65 (20%)
		RhoGEF	3031..3235	CDD:279015	58/218 (27%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	36/164 (22%)
		PH	<3285..3363	CDD:278594	23/102 (23%)
PLEKHG1	NP_001316727.1	RhoGEF	176..351	CDD:279015	59/231 (26%)
		PH_PLEKHG1_G2_G3	332..477	CDD:270063	39/157 (25%)
		PH	381..474	CDD:278594	25/105 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940