DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and prex1

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:XP_699627.3 Gene:prex1 / 570984 ZFINID:ZDB-GENE-030131-1428 Length:1622 Species:Danio rerio


Alignment Length:382 Identity:96/382 - (25%)
Similarity:171/382 - (44%) Gaps:71/382 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  3022 DHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRID---IFSPNSIRLIFSNITAIYKFQ 3083
            |....:|...:.|:|:||.:||:.|..:...:|..:.:..:   ..:...::::||||.:|....
Zfish    23 DRQLRLRLCVLNEILNTERDYVRNLTFLQSAFLQRIRQTAENQQCLTQEQVKVLFSNIESILDVH 87

  Fly  3084 RKFLEALRRGIE-----QNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENC 3143
            |:||..|...::     .:.:..|||:....|..|..||:.:.:||..|...:::...|..|.:.
Zfish    88 REFLSTLDASLQPEPQAHHSLGHVFLQFKVRFSVYGEYCSNHEKALRLLMELNKIPHIRAFLLHL 152

  Fly  3144 R--ESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLD 3206
            .  ..:...::||..:||:|:||||:|||.|.|::|                ::..|.:||    
Zfish   153 MLLGGKKSTDVPLEGYLLSPIQRICKYPLLLRELLK----------------RTPKKHSDY---- 197

  Fly  3207 VTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIAR---HQASFQNFKGPPLHLHSARFFLQ 3268
                      ..|..||:||:.:...:||.||..|.:..   .|:..:.::|..|........||
Zfish   198 ----------PAVEEALQAMKAVCCNINETKRQMEKLEALEILQSHIEGWEGTNLTDICTELLLQ 252

  Fly  3269 -----VDATRQKQNLWNSSYTLFLFDNQLVYCKR-------------DIIKRSHFIYKGRIFLDR 3315
                 :.|...::.::      |||||.||||||             ..|....::::|||..:.
Zfish   253 GNLLKISAGNIQERVF------FLFDNLLVYCKRKSRVSGKKSTKRTKSINGPQYVFRGRINTEV 311

  Fly  3316 CRVVNVRDGKMFGH----TIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQ 3368
            ..|.||.||....|    |:.|..:|::.:::||:....::|..|.::|..:..||:
Zfish   312 MEVENVEDGTADYHSNNYTVTNGWKIHNTAKNKWFVCMAKNAEDKQKWLDAILKERE 368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620
RhoGEF 3031..3235 CDD:279015 52/213 (24%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 38/154 (25%)
PH <3285..3363 CDD:278594 29/94 (31%)
prex1XP_699627.3 RhoGEF 32..216 CDD:279015 52/213 (24%)
PH_Collybistin_ASEF 221..372 CDD:269931 38/154 (25%)
PH 249..363 CDD:278594 32/119 (27%)
DEP 390..470 CDD:295306
DEP_2_P-Rex 482..574 CDD:239887
PDZ 600..678 CDD:214570
PDZ_signaling 684..745 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.840

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