DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and spata13

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:XP_005162798.1 Gene:spata13 / 568426 ZFINID:ZDB-GENE-091116-25 Length:1251 Species:Danio rerio


Alignment Length:1470 Identity:322/1470 - (21%)
Similarity:514/1470 - (34%) Gaps:446/1470 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  2066 SRSSSSSSYSGGESHEPLNGTGSTTVTPSAGSGSTSHRRALTAKQAEQEHRIRRSRSLQLTERSP 2130
            |.....||:|.....:|.  |....:.||..||.....:.:.::...:|:|:.|.:|        
Zfish     6 SSDLQGSSHSNDPQSDPF--TEDQLMNPSLRSGCRVQVQPVLSEPCYEENRLNRLKS-------- 60

  Fly  2131 NRAHKSIVNVGA-----LVPQQRSVGVPYQQSRVPGGGVFPPTIRTSPAGAKIHVNS-----PAP 2185
               |...|.|.|     |.|.:                    |:|..|..||....:     |..
Zfish    61 ---HAQSVPVIADGQAKLYPSR--------------------TVRLFPTQAKSEDGASQRGPPVT 102

  Fly  2186 PN-----SSVRVRHNETDKARSFDFDYNNFSRGGGAKGSSRTAHTSGSGGDSGS----------- 2234
            |.     :..||..:......|......|.|   .|.|:|:..:.|....||.|           
Zfish   103 PQAWSGLAGFRVMGSFKKLRTSVLQGIQNRS---NAMGASQERNLSSVIEDSSSFLVTKREISIS 164

  Fly  2235 ---------NQNLRVERESRSFDDEICEAVLNNNNGSNGSVSGLRFLQPATDSGQVSMASTSSSR 2290
                     |...|..:.|...|::.||.|......|:.|.|    ::.|..:|::||....:.:
Zfish   165 QTHETEKVLNGTSRTRKTSSVSDEDDCEEVCGFQRNSHFSQS----IRKAYGAGRISMLDMVNKQ 225

  Fly  2291 LRKSNSPVSASGMEAS---RSPQSSGS---------STNNLH------QQARQSGSPQSYGTRLC 2337
            ...:..|...:.:|::   .:..:.|:         |.:|||      ::...:..||:   ..|
Zfish   226 SLSTAEPDPVNTVESTEPCNNQDTQGNVKVLKRLSKSADNLHVFKTHFRRKVATAEPQN---PEC 287

  Fly  2338 DHELTYEMLRKSPIMNFRRGDSGDYELPVMLRNRETINSGGNSEL-----NFMSNETRIYEHPTT 2397
            ...:..:....|..::.:....|.::.|:..|.......|..::|     |..|...|:...|.:
Zfish   288 SSTVMLQRTSSSSSVDLQEHVLGSHQSPMRTRGHLQKLVGSLTDLTVKRKNIASPSPRVPVSPLS 352

  Fly  2398 VLKSQRSLRQSPGSRDDLNLEVAVGVGGDYIYRQPANQPRSSSVKAEFLTTATTKSCTKTLDTCD 2462
            .|....| |::|          .|...|.  .|:|:..|          |.....|..:|:....
Zfish   353 QLHDDYS-RRTP----------CVPTSGR--QRRPSPVP----------TKTQQDSTCQTIPILH 394

  Fly  2463 YWPRCAACQHKSVSGELKKGPSASGKPLTVLDNVQPHVTSVIVN-EDNAVPGPQLRSLEKSNPSW 2526
            ..|.|.|.....:...|:. ||.:  ...:.|.||..|:|..:: .|:|.| |:           
Zfish   395 PAPSCPAVFISDLDDSLEP-PSKT--TALISDYVQMAVSSSELHIGDSACP-PE----------- 444

  Fly  2527 TFLCSGIASICQPV---QQTETDH-STAQEAAEEDIVIRKVKPNKSRRTGRSRSLPSVMLRRLYL 2587
                    ..|:|:   |....|| |...:......:...|..|            .|.|:.|: 
Zfish   445 --------KYCEPMECHQNGLNDHYSQIPQQCSSPCLKPTVNGN------------DVNLQCLW- 488

  Fly  2588 AGMPKPGSNEMGTTSDCAASLSQQI-------KAVSSPT---LSEPCLEEQPQKGTESTDVANTG 2642
                    .|...|.|..||...:|       ...|:|.   ::..|..|.| .||.:|      
Zfish   489 --------TEERETDDLEASSDNRITRAFLKSDEASTPAASPITNSCCSESP-LGTPTT------ 538

  Fly  2643 SSAGSGGLGVLQKFKRTLNNFNNKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMITTTTAS 2707
                                          |.|||.|  :|..|...|........|.       
Zfish   539 ------------------------------PNSPAFV--SASPTSVVPRKRAGRSKPR------- 564

  Fly  2708 DPGSEAGDTSSGKYRFGPLIWRSSKERRKTKY-NRRDKCNSGDSGIQIELEQDEQYSRATMAVSR 2771
             |.|:.|..:|.|:    .|....:|.....| :::|..::|.   .||..:.|.....|...||
Zfish   565 -PVSDYGQLASSKF----CILEEDRELENMDYTSQKDYISNGS---YIESSRPENGHVCTQKESR 621

  Fly  2772 QDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNIGESDKAERK-APES 2835
            :..|                            .|::|          .:::..|..||:| ..||
Zfish   622 KRRP----------------------------ISVIG----------GVDLYSSQPAEQKDDTES 648

  Fly  2836 LPTR--------------------------SLSQPNGLESYG--MGR---------PDLEDSDSD 2863
            ||:.                          |.|.|.||:..|  .||         |.||||.|:
Zfish   649 LPSPVCRPPVPSHRVPPYRAVSARLRPCVFSQSTPIGLDRMGRRKGRRVLSDGSSDPMLEDSVSE 713

  Fly  2864 SVASNEEAISFYP-------------------TTYAEVLYNFTAGGPQELGLERGMLIEILRKEV 2909
            ...|.||.....|                   ..|||.|::......|||..:.|.:|.:|..:.
Zfish   714 EDGSFEELTEGTPYLQPEVDLFTLNQHIESGRAVYAEALWDHVTMEEQELAFKAGEVIRVLDVQE 778

  Fly  2910 GPWWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAE--EATARA 2972
            ..||:|            ::|....|||..|||:             |...:::::|  |:|...
Zfish   779 QDWWWG------------MVGDREAWFPSSFVRV-------------RVNQEDSSSESVESTPDT 818

  Fly  2973 EEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLD 3037
            ||   |:|..:..::                                 |:|...:|.:.|:|::|
Zfish   819 EE---PIPSDSHKQN---------------------------------PEHRKQMRANVVKEIMD 847

  Fly  3038 TEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQ-----N 3097
            ||..|:|.|..||:||:....|...:|:...::.|||||..||:||||||:.|.|....     :
Zfish   848 TERVYIKHLKDICEGYIRQCRKHPGMFTDTQLKTIFSNIEDIYRFQRKFLKDLERKYNPENPHLS 912

  Fly  3098 QVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAELPLSAHLLAPV 3162
            ::...||:..:||..||.|||.:|.|..||:...:....:...|.||..|.:.::.::..||.||
Zfish   913 EIGSCFLQQEEGFSIYSEYCNTHPVACAELQRLMKQSRYKHFFEACRLLQQMIDISIAGFLLTPV 977

  Fly  3163 QRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMR 3227
            |:||:|||.|.|::|..    .||.:|..|..:|.|                          ||:
Zfish   978 QKICKYPLQLGELLKYT----PKEHSDFAGVCAAHK--------------------------AMK 1012

  Fly  3228 GITEAVNEGKRHSE---TIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYTLFLFD 3289
            .:...:||.||..|   |||..|.:..::.|..:...|:......:.||..:.......:.||||
Zfish  1013 NVASLINERKRRLESIDTIAHWQVAILHWAGEDVLARSSELIHSGELTRIVRPGKTQQRSYFLFD 1077

  Fly  3290 NQLVYCKRDIIKRSHFIYKGRIFLDRCRVVNVRDGKMFGHT----IKNSLRI-YSESRDKWYDFS 3349
            :|||:||:|:::|....|:||:..|.....::.||:   ||    :||:..: ::|:.:......
Zfish  1078 HQLVFCKKDVLRRDLLHYRGRMDTDLLEPSDLPDGR---HTELGLLKNAFLLRHAENLNVLCVLC 1139

  Fly  3350 FRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYNYEER 3389
            .:.:..|.|:|...|.||    |.:...:..|.|....:|
Zfish  1140 CKKSQDKQRWLQAFARER----KRVQEDQEMGMEITEAQR 1175

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620 19/84 (23%)
RhoGEF 3031..3235 CDD:279015 67/208 (32%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 37/140 (26%)
PH <3285..3363 CDD:278594 25/82 (30%)
spata13XP_005162798.1 SH3 747..800 CDD:327375 19/64 (30%)
RhoGEF 841..1020 CDD:214619 67/208 (32%)
PH_Collybistin_ASEF 1025..1163 CDD:269931 38/144 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5634
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001415
OrthoInspector 1 1.000 - - otm24762
orthoMCL 1 0.900 - - OOG6_103254
Panther 1 1.100 - - LDO PTHR45834
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 1 1.000 - - X1124
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.840

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