Protein Alignment RhoGEF3 and arhgef9b

DIOPT Version :9

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: XP_021336708.1
• Gene: arhgef9b / 560923
• ZFINID: ZDB-GENE-030131-7745
• Length: 573
• Species: Danio rerio
• Alignment Length: 614
• Identity: 117/614 - (19%)
• Similarity: 201/614 - (32%)
• Gaps: 173/614 - (28%)

  Fly  1981 SSVSVSPFKMQRQRSLTPDRNDSHSSTSSL-----RKQRSNTPESR---------------SLTP 2025
            ||.|:.|.:..|:....|:|   .|.|:::     |::..:.|:.|               |:|.
Zfish    43 SSDSILPCQTLRREKQEPNR---RSRTAAIWRILQRRKAPSDPDRRPHSMILPGEPSFLKLSITN 104

  Fly  2026 EER---RKKGSQLSLGGARQSSSSRSN---TFEGRQRHDDKTPP-----NISRSSSS-SSYSGGE 2078
            :.|   :.|...:..|.|.:.|.|:.|   ..||...:..|..|     |:.::.:. .|::|..
Zfish   105 KVRNFKKLKSPSVFKGKASRISDSKYNIDLKDEGDDMYMCKDSPSSEFKNVFKNKAKRHSFAGHT 169

  Fly  2079 -----SHEPLNGTGSTTVTPSAGSGSTSHRRALTAKQAEQEHRIRRSRSLQLTER-------SPN 2131
                 |.|.::.:|    ||.             ..|.|.::.:......:|:||       .||
Zfish   170 ADFYCSFEDIDPSG----TPD-------------NVQEETKNTVSNHNGCKLSERVIYTKKSHPN 217

  Fly  2132 RAHKSIVNVGALVPQ----QRSVGVPYQQSRVPGGGVFPPTIRTSPAGAKIHVNSPAPPNSSVRV 2192
            .::.:  |...:.|:    ::|..:|.::....||.|.....|.|..|.    .|.....||..
Zfish   218 FSNCN--NSSVIEPEDSCAKQSFKIPQRRRWSRGGDVLNYLRRISLKGK----GSQTLAESSFE- 275

  Fly  2193 RHNETDKARSFDFDYNNFSRGGGAKGSSRTAHTSGSGGDSGSNQNLRVERESRSFDDEICEAVLN 2257
            ..|..||  :.|.||.:.| ....|..:.....||..|.||..:.|      ..|.:.:.|..:.
Zfish   276 SMNTLDK--TIDSDYGSVS-FELVKDLNSAPEQSGVDGKSGHFRGL------LRFFNTVAETAMK 331

  Fly  2258 NNNGSNGSVSGLRFLQPATDSGQVSMASTSSSRLRKSNSPVSASGMEASRSPQSSGSSTNNLHQQ 2322
            ..|.|..      |..|.....|:.:..|..|.....|:|:..         :|......::|.:
Zfish   332 WRNSSRS------FSPPEGQQSQLDLRKTQQSGELIQNTPLPV---------RSEHKDDTSVHGK 381

  Fly  2323 ARQSGSPQSYGTRLCDHELTYEMLRKSPIMNFRRGDSGDYELPVMLR-----------NRETINS 2376
            :                .|..:|.:....:|    |..|...||:|:           :....|:
Zfish   382 S----------------TLPLDMCKVVSTVN----DKVDCSPPVVLKAWRTCPDSPRDSNSLCNN 426

  Fly  2377 GGNSELNFMSNE---TRIYEHPT-TVLKSQRSLRQSPGSRDDLNLEVAVG----VGGDYIY---- 2429
            ...|:....|..   ..|..||. ...:....|:..||..:|.|.:..:.    :..:.|:
Zfish   427 SDESQSQISSTHISLATIESHPRYEEAEPPALLKHLPGKTEDENQDTCMDRKKFICPEDIFKTLS 491

  Fly  2430 RQPANQPRSSSVKAEFLTTATTKSCTKTLDTCDYWPRCAACQHKSVSGELKKGPSASGKPLTVLD 2494
            |.|...|....:||                   ...||.:....:....|        :|:|:..
Zfish   492 RPPGKSPADPPLKA-------------------LLQRCCSLPLPNTLSAL--------EPITLTH 529

  Fly  2495 NVQPHVTSV----IVNEDNAVPGPQLRSL 2519
            .:.|...|:    |:...|:..|...|.|
Zfish   530 VLTPPAKSIAKSSILRMRNSSTGSNRRKL 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015
		PH_Collybistin_ASEF	3240..3373	CDD:269931
		PH	<3285..3363	CDD:278594
arhgef9b	XP_021336708.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5634
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001415
OrthoInspector	1	1.000	-	-		otm24762
orthoMCL	1	0.900	-	-		OOG6_103254
Panther	1	1.100	-	-	O	PTHR45834
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1124
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.840