Protein Alignment RhoGEF3 and arhgef9a

DIOPT Version :9

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: XP_005165263.1
• Gene: arhgef9a / 559868
• ZFINID: ZDB-GENE-070705-271
• Length: 549
• Species: Danio rerio
• Alignment Length: 599
• Identity: 168/599 - (28%)
• Similarity: 264/599 - (44%)
• Gaps: 128/599 - (21%)

  Fly  2880 AEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPELGWFPKEFVRI- 2943
            ||.:::......:||..:.|.:|::|......||:|:|.:||            ||||..|||:
Zfish    13 AEAVWDHVTMADRELAFKAGDVIKVLDASNKDWWWGQIDEEE------------GWFPASFVRVE 65

  Fly  2944 IHCPETDNFFIAHRAAADEAAAEEATARA---EEGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIE 3005
            .|.|::...|..:..||....  .|||:.   :|           |:|.|.|....|.|.....|
Zfish    66 SHPPQSKQLFYINPVAASRLT--NATAKLWVNQE-----------ENTAVEVAESSSEVQNGHAE 117

  Fly  3006 SPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIR 3070
            :.|.||...:.......:...:|.:.:.|::.||.:|:|.|..||:|||....||.|:|:.:.::
Zfish   118 ASPNPSTDCLCLGQPTQNRDQMRANVINEIMSTERHYIKHLKDICEGYLRQCKKRRDMFNDDQLK 182

  Fly  3071 LIFSNITAIYKFQRKFLEALRRGIEQ-----NQVAKVFLKMHKGFLCYSTYCNAYPRALIELETY 3130
            :||.||..||:||..|:..|.:....     :::...||:...||..||.|||.:..|.:||...
Zfish   183 VIFGNIEDIYRFQLSFVRDLEKQFNTEEPHLSEIGPCFLEHQDGFWIYSEYCNNHVDACMELTRL 247

  Fly  3131 DRVKDAR--TILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGA 3193
              ::|||  ...|.||..|.:.::.:..:||.|||:||:|||.|.|::|..::
Zfish   248 --MRDARYQHFFEACRLVQQMIDIAIDGYLLTPVQKICKYPLQLAELLKYTVQ------------ 298

  Fly  3194 KSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSET---IARHQASFQNFKG 3255
                :.:||..              |..||..||.:|:.:||.||..|.   ||:.|||..:::|
Zfish   299 ----EHSDYRY--------------VAAALAVMRNVTQQINERKRRLENIDKIAQWQASVLDWEG 345

  Fly  3256 PPLHLHSARFFLQVDATRQKQNLWNSSYTL-FLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVV 3319
            ..:...|:......:.:...|....|...: ||||:|:|.||:|:|:|....|||||.|||..|:
Zfish   346 EDILDRSSELVYTGEMSWIYQPYGRSQTRIFFLFDHQMVLCKKDLIRRDILYYKGRIDLDRYEVI 410

  Fly  3320 NVRDGK--MFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEMTGF 3382
            :..||:  .|..::||:.::.:...|:.:.|..:....|.|:|.....||    |.:...|..||
Zfish   411 DAIDGRDDDFNVSVKNAFKLANRDTDEIHLFLPKKLEEKIRWLRAFQEER----KMVQEDEKIGF 471

  Fly  3383 EYN-YEER-------------------------------PGDYSDQSDY---DAQDFELATGVTS 3412
            |.: |::|                               ||.|.....|   |..::|
Zfish   472 EISQYQKRQAALTVRRATKQKGVGRSVPPAYPPPVDPMNPGQYLLPDGYGQADGYEYE------- 529

  Fly  3413 GESSLPESPAKSTS 3426
                    |.:|||
Zfish   530 --------PKRSTS 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620	18/61 (30%)
		RhoGEF	3031..3235	CDD:279015	65/210 (31%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	42/138 (30%)
		PH	<3285..3363	CDD:278594	30/80 (38%)
arhgef9a	XP_005165263.1	SH3_ARHGEF9_like	13..64	CDD:212762	19/62 (31%)
		RhoGEF	143..322	CDD:279015	65/210 (31%)
		PH_Collybistin_ASEF	327..466	CDD:269931	43/142 (30%)
		PH	372..458	CDD:278594	30/85 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5634
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001415
OrthoInspector	1	1.000	-	-		otm24762
orthoMCL	1	0.900	-	-		OOG6_103254
Panther	1	1.100	-	-	O	PTHR45834
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1124
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.840