DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF3 and vav2

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	XP_021324720.1	Gene:	vav2 / 556413	ZFINID:	ZDB-GENE-091204-420	Length:	891	Species:	Danio rerio

Alignment Length:	428	Identity:	97/428 - (22%)
Similarity:	167/428 - (39%)	Gaps:	127/428 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  3018 VAQPDHSTIIRRSAVR------------------ELLDTEVNYVKLLAAICDGYLPAMSKRIDIF 3064
            |::|.:.   |||.:|                  |:.:||..|.|.|..|...|:..:.:   :.
Zfish   186 VSEPPYG---RRSLIRYMQKMGMTEDDKRNCCLVEIQETEAKYYKTLEDIEKNYMIPLKQ---VL 244

  Fly  3065 SPNSIRLIFSNITAIYKFQRKFLEALRRGIEQ--NQVAKVFLKMHKGFLCYSTYCNAYPRALIEL 3127
            :|..:..||.|:..|.:.....|.|:...:..  |.:.|:||...:..|.|..||:....|   .
Zfish   245 TPQEMEAIFVNLEDIIRVHFALLRAIDLTMVSGGNGLGKIFLDFKERLLIYGQYCSHMENA---Q 306

  Fly  3128 ETYDRV----KDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGN 3188
            :|.|.:    :|.:..:|.|.......:..|...|:.|:||:.:|.|.|.|::..::::
Zfish   307 KTLDELIATREDVKCKVEECTMKVQEGKFKLQDLLVVPMQRVLKYHLLLKELVSHSMDR------ 365

  Fly  3189 DTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSET---IARHQASF 3250
                                    |:.|. :..|||||:.:...:||.||.:||   |:..|:|.
Zfish   366 ------------------------PERQQ-LKEALEAMQDLAMYINEVKRDNETLKKISEFQSSI 405

  Fly  3251 QNFK------GPPLHLHSARFFLQVD--------ATRQKQNLWNSSYTLFLFDNQLVYCKRDIIK 3301
            :|.:      |.|          ::|        ..|.||:.:     :||||..::.|||   |
Zfish   406 ENLQVKLEEYGRP----------KIDGELKVCSIVNRTKQDRY-----IFLFDKVVIVCKR---K 452

  Fly  3302 RSHFIYKGRIFLDRCRV----VNVRD-----GKMFGHTI-------KNSLRIYSESRD---KWYD 3347
            ..::..|..|.|...::    :|.||     |||:.:..       |...:.:.::.|   ||.:
Zfish   453 GYNYELKEVIELHLYKMSDDPMNNRDMKKSSGKMWSYGFYLIHLQGKQGFQFFCKTEDTKRKWME 517

  Fly  3348 FSFRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYN 3385
             .|..|      :|.:..||....:..:  :|..||.|
Zfish   518 -QFEMA------MSNIKPERATANQHNF--QMHTFEKN 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	46/227 (20%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	38/168 (23%)
		PH	<3285..3363	CDD:278594	24/96 (25%)
vav2	XP_021324720.1	CAMSAP_CH	18..103	CDD:314792
		RhoGEF	211..386	CDD:238091	45/211 (21%)
		PH_Vav	401..528	CDD:269930	33/151 (22%)
		C1	536..579	CDD:237996	4/13 (31%)
		SH3	601..660	CDD:327375
		SH2_Vav2	680..782	CDD:198269
		SH3_VAV2_2	832..889	CDD:212910
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940