DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF3 and ARHGEF38

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_001229658.1	Gene:	ARHGEF38 / 54848	HGNCID:	25968	Length:	777	Species:	Homo sapiens

Alignment Length:	434	Identity:	94/434 - (21%)
Similarity:	172/434 - (39%)	Gaps:	110/434 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  3028 RRSAVRELLDTEVNYVK-LLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALR 3091
            |...::||:.||.:|:. |...:.:...|..:|:.|....:|   :||||.::::...|.|..|.
Human    95 REKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDS---LFSNIESVHQISAKLLSLLE 156

  Fly  3092 RGIEQNQ-----VAKVFLKMHKGFL--CYSTYCNAYPRALIELETYDRVKDARTILENCRES--- 3146
            ......:     :.:|||:: ||.|  .|..||..:..|...||:|::.::.:..|.:|.:|
Human   157 EATTDVEPAMQVIGEVFLQI-KGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLKK 220

  Fly  3147 -------QNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQ 3204
                   .||  |.:.:.::.|:||:.:|||.|.|:..|                :.....||..
Human   221 IYMQEGKPNL--LDMGSLMIKPIQRVMKYPLLLCELRNS----------------TPPSHPDYRA 267

  Fly  3205 LDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQASFQN----FKGPPLHLHSAR- 3264
            ||.              |..|::.|...:||.||..:.:.:::.:.::    .|...|::||..
Human   268 LDD--------------AFAAVKDINVNINELKRRKDLVLKYKKNDEDESLKDKLSKLNIHSISK 318

  Fly  3265 ---------FFLQVDATRQKQNLWNSSYTLF-LFDNQLVYCKRDIIKRSHFIYKG-----RIFLD 3314
                     ..|....::.|.|.:|....|| ..:..:..|.::|......|...     :..:|
Human   319 KSKRVTNHLKILTRGESQVKDNTFNREEKLFRALEKTVRLCVKNISLCLQHIQDAMPLALQSVMD 383

  Fly  3315 RCRVVNVRDGKM-FGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLST--LALERQFGG----- 3371
            ...:...:|.:| :..|:.|:|       :..:||    |:...|.:.|  .||...|.|
Human   384 LQEISYNKDDEMDYSETLSNAL-------NSCHDF----ASHLQRLILTPLSALLSLFPGPHKLI 437

  Fly  3372 -----KAL----YVSEMTGFEYNYEERPGDYSDQSDYDAQDFEL 3406
                 |.|    |:...||.|.:..::        :|:|.:.:|
Human   438 QKRYDKLLDCNSYLQRSTGEESDLAKK--------EYEALNAQL 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	52/221 (24%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	28/165 (17%)
		PH	<3285..3363	CDD:278594	16/86 (19%)
ARHGEF38	NP_001229658.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..72
		RhoGEF	98..284	CDD:279015	52/221 (24%)
		BAR_DNMBP	336..522	CDD:153273	32/157 (20%)
		SH3	586..642	CDD:302595
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..694
		SH3_DNMBP_C2	717..773	CDD:213017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810