DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and ARHGEF38

DIOPT Version :10

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:NP_001229658.1 Gene:ARHGEF38 / 54848 HGNCID:25968 Length:777 Species:Homo sapiens


Alignment Length:434 Identity:94/434 - (21%)
Similarity:172/434 - (39%) Gaps:110/434 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  3028 RRSAVRELLDTEVNYVK-LLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALR 3091
            |...::||:.||.:|:. |...:.:...|..:|:.|....:|   :||||.::::...|.|..|.
Human    95 REKIIKELIQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDS---LFSNIESVHQISAKLLSLLE 156

  Fly  3092 RGIEQNQ-----VAKVFLKMHKGFL--CYSTYCNAYPRALIELETYDRVKDARTILENCRES--- 3146
            ......:     :.:|||:: ||.|  .|..||..:..|...||:|::.::.:..|.:|.:|   
Human   157 EATTDVEPAMQVIGEVFLQI-KGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLKK 220

  Fly  3147 -------QNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQ 3204
                   .||  |.:.:.::.|:||:.:|||.|.|:..|                :.....||..
Human   221 IYMQEGKPNL--LDMGSLMIKPIQRVMKYPLLLCELRNS----------------TPPSHPDYRA 267

  Fly  3205 LDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQASFQN----FKGPPLHLHSAR- 3264
            ||.              |..|::.|...:||.||..:.:.:::.:.::    .|...|::||.. 
Human   268 LDD--------------AFAAVKDINVNINELKRRKDLVLKYKKNDEDESLKDKLSKLNIHSISK 318

  Fly  3265 ---------FFLQVDATRQKQNLWNSSYTLF-LFDNQLVYCKRDIIKRSHFIYKG-----RIFLD 3314
                     ..|....::.|.|.:|....|| ..:..:..|.::|......|...     :..:|
Human   319 KSKRVTNHLKILTRGESQVKDNTFNREEKLFRALEKTVRLCVKNISLCLQHIQDAMPLALQSVMD 383

  Fly  3315 RCRVVNVRDGKM-FGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLST--LALERQFGG----- 3371
            ...:...:|.:| :..|:.|:|       :..:||    |:...|.:.|  .||...|.|     
Human   384 LQEISYNKDDEMDYSETLSNAL-------NSCHDF----ASHLQRLILTPLSALLSLFPGPHKLI 437

  Fly  3372 -----KAL----YVSEMTGFEYNYEERPGDYSDQSDYDAQDFEL 3406
                 |.|    |:...||.|.:..::        :|:|.:.:|
Human   438 QKRYDKLLDCNSYLQRSTGEESDLAKK--------EYEALNAQL 473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 SH3 2876..2942 CDD:214620
RhoGEF 3028..3234 CDD:238091 53/223 (24%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 28/165 (17%)
ARHGEF38NP_001229658.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..72
RhoGEF 98..283 CDD:459876 52/220 (24%)
BAR_DNMBP 336..522 CDD:153273 32/157 (20%)
SH3 586..642 CDD:473055
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..694
SH3_DNMBP_C2 717..773 CDD:213017
Blue background indicates that the domain is not in the aligned region.

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