DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF3 and ARHGEF37

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	XP_011535944.1	Gene:	ARHGEF37 / 389337	HGNCID:	34430	Length:	686	Species:	Homo sapiens

Alignment Length:	460	Identity:	96/460 - (20%)
Similarity:	163/460 - (35%)	Gaps:	146/460 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  3005 ESPPTPS-APSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNS 3068
            :.|.:.| :|..:..|..|.|.:.:|.|||||:||||:|:.:| .:|   ...:..|:.......
Human    18 DEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHML-QLC---ASDIRSRLQQLPQGD 78

  Fly  3069 IRLIFSNITAIYKFQRKFLEALRRGIEQNQ-----VAKVFLKMHKGF-LCYSTYCNAYPRALIEL 3127
            :.::||||..|.|...:||..|:....:.:     |..:||:..:.. ..|..||.:|.:||:.:
Human    79 LDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLV 143

  Fly  3128 ETYDRVKDARTILENCRESQNLAE--LP------LSAHLLAPVQRICRYPLHLNEIIKSALEKGA 3184
            :||.:..:.:      |..|.:.|  :|      ||..|:.|:|||.||||.|.:|:::.
Human   144 DTYRKEPELQ------RHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENT----- 197

  Fly  3185 KEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQ--DTVNLALEAMRGITEAVNEGKRHSETIARHQ 3247
                                       :||:.  ..:..|:.|::.:...:||.|...|..
Human   198 ---------------------------VPDASAYPVLQRAVSALQDVNTNINEYKMRKEVA---- 231

  Fly  3248 ASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIF 3312
                                             |.||..   .||...:|.....:|.:.|....
Human   232 ---------------------------------SKYTKV---EQLTLRERLARINTHTLSKKTTR 260

  Fly  3313 LDRCRVVNVRDGKMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVS 3377
            |.:              .:|....:...:.||.:|    ....:.:::|....|.: ...|.|:.
Human   261 LSQ--------------LLKQEAGLIPRTEDKEFD----DLEERFQWVSLCVTELK-NNVAAYLD 306

  Fly  3378 EMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAKSTSRLC-----ETLPKKSQ 3437
            .:..|.|   .||.:|:                    ..:||.||.....|.     |...|..|
Human   307 NLQAFLY---FRPHEYN--------------------LDIPEGPAVQYCNLARDLHLEAFLKFKQ 348

  Fly  3438 SRDGI 3442
            ..:|:
Human   349 RLEGL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	54/219 (25%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	16/132 (12%)
		PH	<3285..3363	CDD:278594	11/77 (14%)
ARHGEF37	XP_011535944.1	RhoGEF	45..223	CDD:279015	54/219 (25%)
		BAR_DNMBP	275..463	CDD:153273	21/107 (20%)
		SH3_ARHGEF37_C1	521..574	CDD:212733
		SH3_ARHGEF37_C2	617..673	CDD:212874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810