DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and Arhgef28

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:XP_038958459.1 Gene:Arhgef28 / 361882 RGDID:1307061 Length:1714 Species:Rattus norvegicus


Alignment Length:2099 Identity:373/2099 - (17%)
Similarity:640/2099 - (30%) Gaps:754/2099 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   800 AGTLPSSAQDDQVERLEAPPASMEQQQYADLKQNKY----AQDFFKHVNDVKRSIYQSEMKRNNS 860
            |||:..|..:        .|...::..||...:|.|    |:.:|.:....:|.:..::...:|.
  Rat    12 AGTMELSCSE--------VPLYGQRTVYAKFGKNVYLPEDAEFYFIYDGSHQRHVVIADRVEDNV 68

  Fly   861 LESSRSGPRAGGSTKSNV-----KASPKRAASQETRLVTTLP--LSRSRLSAGVKPTPAPRTSLQ 918
            |:|...|.....:...:|     ..||....|.....|..:.  |:|..::...:.||....:|.
  Rat    69 LQSIIPGHWLQETVMVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQADRLTPCSHQTLL 133

  Fly   919 TPTPLPETTVAKDPTPSKRKSQPTVRREYPSLD-RLVASTT-------GTIPKKNSRNI------ 969
            ||..|....:                   |:|| .||.:.|       .|:...:|..:      
  Rat   134 TPFALTAEAL-------------------PALDEELVLALTQLELPLGWTVLGNSSLEVCLHRES 179

  Fly   970 ---TAASLQSPKLTQKTRSEAPEKKVAPEDQLPLPPSGKRHHRTGASKTNTNAPCSSLRRKDIPA 1031
               .|.....|||....              |.||                    ..::..::|.
  Rat   180 LLHLAVRWALPKLFHFL--------------LCLP--------------------GGVKALELPN 210

  Fly  1032 PPPPSP------ATYSDLQELKANMEGFRDDTKSR-------SLEYDTND--------------L 1069
            ....:|      ..:|.|.|..:|.:|.|....||       :|::|.:.              |
  Rat   211 EEATTPLDLALHGGHSMLVEDISNFQGRRSPGFSRLRLNEDATLQFDRSSETLTLTVNHTAEHLL 275

  Fly  1070 TAD------------------DNSNKTQKKSL-SGPPNPMTEAPIGATDAGAVETDDNDVFYDAR 1115
            .||                  |...||::.:: ||...  ||..:...::|...:::.:.....:
  Rat   276 EADIKLFRKYFWDRAFLVKALDQEAKTERATMPSGAAE--TEEEVRNLESGRSPSEEEEDGQLVK 338

  Fly  1116 SEDSGGGILPSNTSDISKMSPSHMATFTRAATNENRKGAFDNEKEHSAEDDDSPSPAAPAPEGRE 1180
            |:..|    ||...|..::...|               :||..|:         |..|||.....
  Rat   339 SQADG----PSEQEDQDRLVLDH---------------SFDGLKK---------SKHAPASLAAG 375

  Fly  1181 QASSITGRPKGNGNSKITTTPSC----ELGS------SAEAESKLDSAALCRPRPRPRQASPHLP 1235
            |.|.:.     ||..::..  :|    ::|.      :.|..|...|....|....|:.....||
  Rat   376 QLSDVP-----NGGDEVYA--NCMVIDQVGDLDINYINIEGLSTHTSPESMRSTLGPQACKHILP 433

  Fly  1236 PECTDTGGAGDEQASKTKHEKKTPADAPRQHVGPTCSEGQRTAALATNVACALSTTTNAGNTSAS 1300
            |:.:..|                       |:  .|.:..||...|.:.:|....:::..|.:.|
  Rat   434 PDTSPCG-----------------------HL--LCEDSDRTLDAAASQSCMSPPSSHTSNLNLS 473

  Fly  1301 ----------------NSVLELELSCKTGNTDSETP---AV-AHSDPTSDVPA------------ 1333
                            :|.|:..::.......||.|   || :.|.|.:.:|.            
  Rat   474 FGLHGFVKEQSHLKKRSSSLDALVADSEEEGRSEPPICYAVGSQSSPRTGLPGGDELDSFDANTE 538

  Fly  1334 --CGTAENPT-------H-----LRALTRQDYACIDSSEAQSDDSHLTRDSITRESQNDELSSS- 1383
              |..:...:       |     |..:..:.|:| .|.:..|..|.|.||.....|..::.|.| 
  Rat   539 PDCNISRTESLSLSSTLHSKESLLSGIRSRSYSC-SSPKISSGKSRLVRDFTVCSSSEEQRSYSF 602

  Fly  1384 ---------TLEKLDVSTLPLPALPKRR---RTRS-----RTSPSKHRQQQQQQQQQQQQ--RHE 1429
                     ..|:.|...:|..|..::.   ||.|     .|||....:.:.:..:.:::  ||:
  Rat   603 QEPPGEKRIQEEEWDDYIIPAKAESEKHKVSRTFSFLMNRMTSPRNKSKMKNKDTKDKEKLNRHQ 667

  Fly  1430 VIEDANAVDASTAAAGQQHPKPRQGAASPESQKPEISGAKNNAAGEQQKQPQSQQQQTHLSAFQQ 1494
            .:                 |....|..       :.||......|::..|..:.:..||...   
  Rat   668 FV-----------------PGTFSGVL-------QCSGCDKTLLGKESLQCANCKANTHKGC--- 705

  Fly  1495 YVAKRRESLEASNRCFNEKLEARRMHYHMGGSAANGNATASHLTAGSNGVPTYLFGENFYGVPAT 1559
                 ::::....:.|.:|....:....:|.|:.............|..:|        .|:|| 
  Rat   706 -----KDTVPPCTKKFQDKYNKNKPQTILGSSSVRDVPPPGLSLHPSPSMP--------IGLPA- 756

  Fly  1560 GRKSISPTTKKEEIFLNKS--GWVQVNTTRGVNKDDNGG---GYRSLSYAQQNGGGRVAAMLTDP 1619
            |||.    |..:...|::|  |....:..|.|...::.|   .:||.|::.:......::..|:.
  Rat   757 GRKE----TAGQAHPLSRSVPGTTLESFRRAVTSLESEGDSNSWRSRSHSDELFQSMGSSPSTES 817

  Fly  1620 GRRSDLARKSFILQ-----HQQQHQSNISMTEPKFVGSKVEELIQRNEA--RLSGCSIRYPSLRP 1677
            ....|:...|...:     .:.:.:|...:.:|.|...:.:::|:|.:.  .|....:       
  Rat   818 FMMEDVVDSSLWSELSSDAQEFEAESWSLVVDPSFCSRQEKDVIKRQDVIFELMQTEV------- 875

  Fly  1678 GHRIIDPQLANILNE--RPGFLPVKGPTDLD-SPLTPILSPPPAFQDNSRSARR-----QERRNP 1734
             |.|   |...|::|  |.|   :|....|| |.:..|.   |...:...:.:.     :|||  
  Rat   876 -HHI---QTLLIMSEVFRKG---MKEELQLDHSTVDRIF---PCLDELLETHKHFFFSMKERR-- 928

  Fly  1735 GRQQGPLPLPVPFRSEPQMDPQNPINGSAKGMVFSRSFEYDTRRHTPTDNYVETFSRSFDGNLSD 1799
                                 |....|:.:..|.::.          .|..|:.||.. :.:...
  Rat   929 ---------------------QESCTGNDRNFVINQI----------GDILVQQFSEE-NASKMK 961

  Fly  1800 RLLNLAVLAGQRERSPNFSTLTGNS--PNYLTKRESGGGSSGSLRSRDSSPK--YLHPQATTAYL 1860
            |:.. ...:..:|....|..|..|.  .|::..|     :|..|..|...|:  .|..|..|.| 
  Rat   962 RIYG-DFCSHHKEAMSLFKELQQNKKFQNFIKIR-----NSNLLARRRGIPECILLVTQRITKY- 1019

  Fly  1861 NAAVKEAPPVYSVPTGSQAKYSPRSRFER----TTERSKTHALGRSRKSQFSRVGSAGPLIAHPN 1921
                    ||.               .||    |.||::.|      :.....:|....:||   
  Rat  1020 --------PVL---------------VERILQYTKERTEEH------RDLCRALGLIKDMIA--- 1052

  Fly  1922 TANVGVSRFRSFDTSKSQR----LNSCDSGARSDLSNDELDNE------------DG-------- 1962
            ..::.||.:     .|:|:    ||..::...:.|.|..:..:            ||        
  Rat  1053 AVDLKVSEY-----EKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSQERALLHDGLVYWKTAT 1112

  Fly  1963 G---------LNDFLSAGSHKFPKIGTSSVSVSPFKMQRQR-------------------SLTPD 1999
            |         |.|.|.....|..|...::|...|..:..|:                   |..|:
  Rat  1113 GRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPE 1177

  Fly  2000 RNDSHSSTSSLRKQRSN-----------TPESR----SLTPEERRKKGSQLSLGGARQSSSSRSN 2049
            ..:.|:|:   :::|:|           .||..    |.:.|||||..::::  ..:|.....||
  Rat  1178 MYEIHTSS---KEERNNWMRRIQQAVESCPEEEGGRTSESDEERRKADARVA--KIQQCQEILSN 1237

  Fly  2050 ------TFEGRQRHDDKTPPNISRSSSSSSYSGGES-H-EPLNGTGSTTVTPSAGSGSTSHRRAL 2106
                  |:...:.|         ..:.....||.|. | ||     ...:.|..|....:.....
  Rat  1238 QDQQICTYLEEKLH---------IYAELGELSGFEDVHLEP-----HLLIKPDPGEPPQAASLLA 1288

  Fly  2107 TAKQAEQEHRIRRSRSLQLTERSPNRAHKSIVNVGALVPQQRSVGVPYQQSRVPGGGVFPPTIRT 2171
            .|        :|.:.|||:..::...|               .|..|.::.  |||.|...|:..
  Rat  1289 AA--------LREAESLQVAVKASKLA---------------DVSQPSEEG--PGGAVLADTLSA 1328

  Fly  2172 SPAGAKIHVNSPAPPNSSVRVRHNETDKARSFDFDYNNFSRGGGAKGSSRTAHTSGSGGD----- 2231
            ..|        ||.|                                   ||.|.|:.|.     
  Rat  1329 QDA--------PASP-----------------------------------TAFTEGTEGRGCWDV 1350

  Fly  2232 -------------SGSNQNLRVERESRSFDDEICEAVLNNNNGSNGSVSGLRF-LQPA---TDS- 2278
                         |.:.:.:.....|.|...||.:|:.|        ::.|.: ||.|   .|| 
  Rat  1351 DPRLQGVVTDLAVSDAGEKVEYRSFSGSSQSEIIQAIQN--------LTRLLYSLQAALTIQDSH 1407

  Fly  2279 ---------GQVSMASTSSSRLRKSNSPVSASGMEASRSPQSSGSSTNNLHQQARQSGSPQSYGT 2334
                     .|.|:|.:.|.|    ..|:  ...|.||..:.......|:|:...|....|....
  Rat  1408 IEIHKLVLQQQESLAPSHSFR----GGPL--QDQEKSRYLEKHREELANIHKLQYQFQQEQRRWH 1466

  Fly  2335 RLCDHELTYEMLRKSPIMNFRRGDSGDYELPVMLRNRETINSGGNSELN-----FMSNETRIYEH 2394
            |.||.:...:..::|.:....|......||  :||:|        |||:     :..|..|:.|.
  Rat  1467 RTCDQQQREQEAQESWLQARERECQSQEEL--LLRHR--------SELDHQLQEYQQNLERLREG 1521

  Fly  2395 PTTVLKSQRSLRQ--------------------SPGSRD--DLNLEVAVGVGGDYIYRQPANQPR 2437
            ...|.:.::.:|.                    ||||::  :||                    |
  Rat  1522 QRMVERERQRMRDQQGLLGHCKHSRQRSLPAVFSPGSKEVTELN--------------------R 1566

  Fly  2438 SSSV---KAEFLTTATTKSCTKTLDTCDYWPRCAACQHKSVSGELKKGPSASGKPLTV------- 2492
            :.|:   |:.||..|.|                    |.|::...|  |:.||.|...       
  Rat  1567 AESLCHEKSFFLNDAFT--------------------HMSLNTSNK--PNPSGAPWDAHPPGGSH 1609

  Fly  2493 LDNVQPHVTSVIVNEDNAVP------------GPQLRSLEKSNPSWTFLCSGIASICQPVQQTET 2545
            ||..:...:.:.|..|.:.|            |||..:.::|...   .|..:|.:.....::..
  Rat  1610 LDLARTSDSQIEVKMDVSQPSDVNSELWTTGLGPQRPARQESIKD---SCKNVADLNSFQTESPD 1671

  Fly  2546 DHSTAQEAAEEDIVIRKVK 2564
            ...:.|...:...:|.:.|
  Rat  1672 PQDSNQRGPQPQTLITEAK 1690

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620
RhoGEF 3031..3235 CDD:279015
PH_Collybistin_ASEF 3240..3373 CDD:269931
PH <3285..3363 CDD:278594
Arhgef28XP_038958459.1 C1_p190RhoGEF 659..719 CDD:410426 11/91 (12%)
RhoGEF 866..1055 CDD:214619 50/278 (18%)
PH_p190RhoGEF 1100..1200 CDD:275430 17/102 (17%)
DUF5401 <1368..>1536 CDD:375164 43/191 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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