DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF3 and Arhgef37

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_808496.2	Gene:	Arhgef37 / 328967	MGIID:	3045339	Length:	676	Species:	Mus musculus

Alignment Length:	238	Identity:	66/238 - (27%)
Similarity:	114/238 - (47%)	Gaps:	45/238 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  3005 ESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSI 3069
            |:.....:|..:.....|.|.:.:|.|:|||:||||:|:.:| .:|...:.:..:::   .|..:
Mouse     8 EASSKSESPEQEDQGSEDRSLLHQRLAIRELIDTEVSYLHML-RLCASDIRSHLQQL---PPGDL 68

  Fly  3070 RLIFSNITAIYKFQRKFLEALR----RGIEQ-NQVAKVFLKMHKGF-LCYSTYCNAYPRALIELE 3128
            .::||||..|.:...:||..|:    |..|| :.:..:||:..:.| ..|..||..|.:||:.::
Mouse    69 DILFSNIDDIIQVSSRFLRGLQETACREEEQAHLIGNLFLEFQEEFEQVYKVYCANYDQALLLVK 133

  Fly  3129 TYDR----VKDARTILENCRESQNLAELP------LSAHLLAPVQRICRYPLHLNEIIKS----- 3178
            .|.:    .|:.:.|:|        |.:|      ||..|:.|:|||.:|||.|.:|:::
Mouse   134 AYQKEPELQKEIQGIIE--------AAMPQAGPSGLSFFLVIPLQRITKYPLLLQKILENTPADA 190

  Fly  3179 ----ALEKGAKEGNDTDG--------AKSAGKTTDYEQLDVTE 3209
                ||::......|.:|        .:.|.|.|..|||.:.|
Mouse   191 SAHPALQRATSALQDVNGNINEYKMRKEVALKYTKVEQLSLRE 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	61/212 (29%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931
		PH	<3285..3363	CDD:278594
Arhgef37	NP_808496.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		2/17 (12%)
		RhoGEF	34..211	CDD:366202	54/188 (29%)
		BAR_DNMBP	264..452	CDD:153273
		SH3_ARHGEF37_C1	510..563	CDD:212733
		SH3_ARHGEF37_C2	607..663	CDD:212874
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810