DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF3 and Prex1

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_001129190.1	Gene:	Prex1 / 311647	RGDID:	1306534	Length:	1646	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	106/376 - (28%)
Similarity:	173/376 - (46%)	Gaps:	66/376 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  3027 IRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRI-----DIFSPNSIRLIFSNITAIYKFQRKF 3086
            :|...:.|:|.||.:||..|..:...:|..:.:.:     ...:..:::::||||..|.:..:.|
  Rat    44 LRLCVLNEILATERDYVGTLRFLQSAFLQRIRQNVADSVDKGLTEENVKILFSNIEDILEVHKDF 108

  Fly  3087 LEALRRGI-----EQNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCR-- 3144
            |.||...:     .|:::..||||....|..|..||:.:.:||..|...::|..||..|.||.
  Rat   109 LAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAARAFLLNCMLL 173

  Fly  3145 ESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTE 3209
            ..:...::||..:||:|:||||:|||.|.|:.|                ::.||..|:
  Rat   174 GGRKTTDIPLEGYLLSPIQRICKYPLLLKELSK----------------RTPGKHPDH------- 215

  Fly  3210 LDIPDSQDTVNLALEAMRGITEAVNEGKRHS---ETIARHQASFQNFKGPPLHLHSARFFLQVDA 3271
                   ..|..||:||:.:...:||.||..   |.:.:.|:..:.::|..|.....:..||  .
  Rat   216 -------SAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQ--G 271

  Fly  3272 TRQKQNLWN-SSYTLFLFDNQLVYCKR--------------DIIKRSHFIYKGRIFLDRCRVVNV 3321
            |..|.:..| .....|||||.||||||              ..|..|.:|::|||..:...|.||
  Rat   272 TLLKISAGNIQERAFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENV 336

  Fly  3322 RDG----KMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQ 3368
            .||    ...|:|:.|..:|::.:::||:....::|..|.::|..|..||:
  Rat   337 EDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIRERE 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	58/215 (27%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	43/151 (28%)
		PH	<3285..3363	CDD:278594	31/95 (33%)
Prex1	NP_001129190.1	RhoGEF	48..234	CDD:279015	58/215 (27%)
		PH_Collybistin_ASEF	239..391	CDD:269931	43/151 (28%)
		PH	278..384	CDD:278594	33/105 (31%)
		DEP	409..489	CDD:295306
		DEP_2_P-Rex	501..593	CDD:239887
		PDZ	630..697	CDD:214570
		PDZ	714..768	CDD:238080
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810