DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF3 and Arhgef37

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_001094444.2	Gene:	Arhgef37 / 307398	RGDID:	1560471	Length:	676	Species:	Rattus norvegicus

Alignment Length:	625	Identity:	142/625 - (22%)
Similarity:	229/625 - (36%)	Gaps:	148/625 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  3005 ESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICD----GYLPAMSKRIDIFS 3065
            |:.....:|..:.....|.|.:.:|.|:|||:||||:|:..| .:|.    |:|..:       .
  Rat     8 EASSKSESPEQEGQGSEDKSLLHQRLAIRELIDTEVSYLHTL-RLCTSDIRGHLQQL-------P 64

  Fly  3066 PNSIRLIFSNITAIYKFQRKFLEALRRGI--EQNQ---VAKVFLKMHKGF-LCYSTYCNAYPRAL 3124
            |..:.::||||..|.:...:||..|:...  |:.|   :..:||:..:.. ..|..||..|.:||
  Rat    65 PGDLDILFSNIDDIIQVSSRFLHGLQETACKEEKQAHLIGNLFLEFQEELEQVYKVYCANYDQAL 129

  Fly  3125 IELETYDR----VKDARTILENCRESQNLAELP------LSAHLLAPVQRICRYPLHLNEIIK-- 3177
            :.::.|.:    .|:.:.|:|        |.:|      ||..|:.|:|||.:|||.|.:|::
  Rat   130 LLVKAYQKEPELQKEIQGIIE--------AAVPQAGPSGLSFLLVIPLQRITKYPLLLQKILENT 186

  Fly  3178 --------------SALEKGAKEGNDTDGAKS-AGKTTDYEQLDV----------------TELD 3211
                          |||:......|:....|. |.|.|..|||.:                |.|.
  Rat   187 PADASAHPVLQRATSALQDVNSNINEYKMRKEVALKYTKVEQLSLRERLARINTHTLSKKTTRLS 251

  Fly  3212 ---------IPDSQDT-----------VNLALEAMRGITEAVNEGKRHSETIARHQASFQNFKGP 3256
                     :|.::|.           |:|.:..::....|..:..........|:.:.....|.
  Rat   252 QLLKQEAGLVPRTEDKEFDDLEERFQWVSLCVTELKSNVAAYMDNLEAFLCFRPHERNLDIPGGA 316

  Fly  3257 PLHLHSARFFLQVDATRQ-KQNL----WNSSYTL---FLFDNQLVYCKRDIIKRSHFIYKGRIFL 3313
            .....|....||:.|..| ||.|    |....:|   .:....|:  |:.:.|...|.......|
  Rat   317 AEQYCSLARDLQLQAFLQFKQRLTGLVWQPLCSLARALVGPQNLI--KKRLDKLLDFERVEEKLL 379

  Fly  3314 DRCRVVNVRDGKMFGHTIKNSLRI-----YSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKA 3373
            |...|....:.....:...|||.:     ::....:|.....|:.....|.|:...|.|.....|
  Rat   380 DVGSVTYEEEAARHTYQALNSLIVAELPQFNHLVMQWLGQILRTFVVLQRDLADQVLRRAESSMA 444

  Fly  3374 L----YVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPES------------PA 3422
            |    :||| ..|:...|:..|..|.|..:..:.||.....::.:..||.|            |.
  Rat   445 LLPHRHVSE-PDFQKLLEDTLGQSSSQLRHFRESFEKVLPPSTSQPLLPGSEHQMQSLLTRYGPG 508

  Fly  3423 K---------STSRLCETLPKKS-----QSRDGISSAENSQIVTTTS-------TGSLGRRHFGN 3466
            |         .|..|..|||:..     |::|  :...||:.:..|.       .|.|...|..|
  Rat   509 KIYQVTSNINGTGTLDLTLPRGQIVALLQNKD--TKGNNSRWLVDTGGHRGYVPAGKLQLYHPIN 571

  Fly  3467 WFRK-PKSANCTPSQ--SPTHKPSFDADATL-TEARVAAM 3502
            ...| |:.....|..  .||.:|:..:..|: |.::|.|:
  Rat   572 PSEKEPRRQTGMPEDYWLPTPEPTQPSVPTVPTMSQVVAV 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	68/276 (25%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	28/145 (19%)
		PH	<3285..3363	CDD:278594	15/85 (18%)
Arhgef37	NP_001094444.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		2/17 (12%)
		RhoGEF	34..211	CDD:395496	53/192 (28%)
		BAR_DNMBP	264..452	CDD:153273	34/189 (18%)
		SH3_ARHGEF37_C1	510..563	CDD:212733	10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..601		8/32 (25%)
		SH3_ARHGEF37_C2	607..663	CDD:212874	2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..676
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810