DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and Prex1

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:NP_808450.2 Gene:Prex1 / 277360 MGIID:3040696 Length:1650 Species:Mus musculus


Alignment Length:376 Identity:102/376 - (27%)
Similarity:173/376 - (46%) Gaps:66/376 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  3027 IRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRI-----DIFSPNSIRLIFSNITAIYKFQRKF 3086
            :|...:.|:|.||.:||..|..:...:|..:.:.:     ...:..:::::||||..|.:..:.|
Mouse    44 LRLCVLNEILGTERDYVGTLRFLQSAFLQRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDF 108

  Fly  3087 LEALRRGI-----EQNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCR-- 3144
            |.||...:     .|:::..||||....|..|..||:.:.:||..|...::|...|..|.:|.  
Mouse   109 LAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKVPAVRAFLLSCMLL 173

  Fly  3145 ESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTE 3209
            ..:...::||..:||:|:||||:|||.|.|:.|                ::.||..|:       
Mouse   174 GGRKTTDIPLEGYLLSPIQRICKYPLLLKELAK----------------RTPGKHPDH------- 215

  Fly  3210 LDIPDSQDTVNLALEAMRGITEAVNEGKRHS---ETIARHQASFQNFKGPPLHLHSARFFLQVDA 3271
                   ..|..||:||:.:...:||.||..   |.:.:.|:..:.::|..|........||.:.
Mouse   216 -------TAVQSALQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTELLLQGNL 273

  Fly  3272 TR-QKQNLWNSSYTLFLFDNQLVYCKR--------------DIIKRSHFIYKGRIFLDRCRVVNV 3321
            .: ...|:...::  |||||.||||||              ..|..|.:|::|||..:...|.||
Mouse   274 LKISAGNIQERAF--FLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENV 336

  Fly  3322 RDG----KMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQ 3368
            .||    ...|:|:.|..:|::.:::||:....::|..|.::|..|..||:
Mouse   337 EDGTADYHSNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDALIRERE 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620
RhoGEF 3031..3235 CDD:279015 56/215 (26%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 41/151 (27%)
PH <3285..3363 CDD:278594 31/95 (33%)
Prex1NP_808450.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..33
RhoGEF 48..234 CDD:279015 56/215 (26%)
PH_Collybistin_ASEF 239..391 CDD:269931 41/151 (27%)
PH 267..384 CDD:278594 35/118 (30%)
DEP 409..489 CDD:295306
DEP_2_P-Rex 501..593 CDD:239887
PDZ 630..697 CDD:214570
PDZ 714..768 CDD:238080
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 793..813
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1047
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1129
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43009
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.840

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