DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and TIAM2

DIOPT Version :10

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:NP_036586.3 Gene:TIAM2 / 26230 HGNCID:11806 Length:1701 Species:Homo sapiens


Alignment Length:1598 Identity:307/1598 - (19%)
Similarity:527/1598 - (32%) Gaps:507/1598 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1993 QRSLTPDRNDSHSSTSSLRKQRSNTPESRSLTPEERRKK---GSQLSLGGARQSSSSRS--NTFE 2052
            |.:|...:|  ||:|.:..||...:.:.|.:..:|.:..   |...:..|.:..|.:||  :.|:
Human     7 QYTLQGSKN--HSNTITGAKQIPCSLKIRGIHAKEEKSLHGWGHGSNGAGYKSRSLARSCLSHFK 69

  Fly  2053 GRQRHDDKTPPNISRSSSSSSYSGGESHEP---LNGTGSTTVTPSAGSGSTSHRRA---LTAKQA 2111
            ..|.:..:......:.|...:||...::.|   ..|..:...|.: |..|..|..|   :|::..
Human    70 SNQPYASRLGGPTCKVSRGVAYSTHRTNAPGKDFQGISAAFSTEN-GFHSVGHELADNHITSRDC 133

  Fly  2112 EQEHRIR---RSRSLQLT-----ERSPNRAHKSIVNV-GALVPQQRSVGVPYQQSRVPGGGV--- 2164
             ..|.:.   |:.|:..|     .:||....|::..: |.|..:..:.|.|   |:||....   
Human   134 -NGHLLNCYGRNESIASTPPGEDRKSPRVLIKTLGKLDGCLRVEFHNGGNP---SKVPAEDCSEP 194

  Fly  2165 -----FPPTI--RTSP--------AGAKIHVNSPAPPNSSVRVRHNETDKARS--FDFDYNNFSR 2212
                 :.||:  .|||        :...:..:.|:|.:|.:|.....:..:.|  :|..:.|...
Human   195 VQLLRYSPTLASETSPVPEARRGSSADSLPSHRPSPTDSRLRSSKGSSLSSESSWYDSPWGNAGE 259

  Fly  2213 GGGAKGS-------SRTAHTSGSGGDSGSNQNLRVERESRSFDDEICEAVLNNNNGSNGSVSGLR 2270
            ...|:||       ..:.|.|...||:....|     :|.|. ..:.|...:.|.||. |.||:|
Human   260 LSEAEGSFLAPGMPDPSLHASFPPGDAKKPFN-----QSSSL-SSLRELYKDANLGSL-SPSGIR 317

  Fly  2271 FLQP-----ATDSGQVSMAS--------------------------------------------- 2285
            ....     |:.|.:||.||                                             
Human   318 LSDEYMGTHASLSNRVSFASDIDVPSRVAHGDPIQYSSFTLPCRKPKAFVEDTAKKDSLKARMRR 382

  Fly  2286 ------TSSSRLRKSNSPVSASG------------MEASRSPQS-----SGSSTNNLHQQARQSG 2327
                  :.|.:.||...|.|..|            .:...|.|:     ||.||..|.|::..: 
Human   383 ISDWTGSLSRKKRKLQEPRSKEGSDYFDSRSDGLNTDVQGSSQASAFLWSGGSTQILSQRSEST- 446

  Fly  2328 SPQSYGTRLCDHELTYEMLRKSPIMNFRRGDSGDYELPVMLRNRETINSGGNSELNFMSNETRIY 2392
                       |.:..:.||::...||.|      ||.:...|.|.|.:         |.||.  
Human   447 -----------HAIGSDPLRQNIYENFMR------ELEMSRTNTENIET---------STETA-- 483

  Fly  2393 EHPTTVLKSQRSLRQSPGSRDDLNLEVAVGV--GGDYIYRQPANQPRSSSVKAEFLTT------- 2448
            |..:..|.|...|        ||..|...||  ...:::.:|....:... |.|.:..       
Human   484 ESSSESLSSLEQL--------DLLFEKEQGVVRKAGWLFFKPLVTVQKER-KLELVARRKWKQYW 539

  Fly  2449 ATTKSCT---------KTLDTCDYWPRCAACQHKSVSGELKKGPSASGKPLTVLDNVQPHVTSVI 2504
            .|.|.||         .::|.... ||||.....|:...:.:.|                     
Human   540 VTLKGCTLLFYETYGKNSMDQSSA-PRCALFAEDSIVQSVPEHP--------------------- 582

  Fly  2505 VNEDNAVPGPQLRSLEKSNPSWTFLCS---GIASICQPVQQTETD------HST-----AQEAAE 2555
                           :|.|   .|..|   |...:.|...||:.:      ||.     |::..:
Human   583 ---------------KKEN---VFCLSNSFGDVYLFQATSQTDLENWVTAVHSACASLFAKKHGK 629

  Fly  2556 EDIVIRKVKPNKSRRTGRSRSLPSVMLRRLYLAGMPKPGSNEMGTTSDCAASLSQQIKAVSSPTL 2620
            || .:|.:| |:::...:...:.|.|.:...|                       |:..||.|. 
Human   630 ED-TLRLLK-NQTKNLLQKIDMDSKMKKMAEL-----------------------QLSVVSDPK- 668

  Fly  2621 SEPCLEEQPQKGTESTD-----------------------------VANTGSSAGSGGLGVL--Q 2654
            :...:|.|.|:..::.:                             .|:..|....|.||:|  .
Human   669 NRKAIENQIQQWEQNLEKFHMDLFRMRCYLASLQGGELPNPKSLLAAASRPSKLALGRLGILSVS 733

  Fly  2655 KF-------------KRTLN---NFNNKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMITT 2703
            .|             ||||:   ...||..: .|.|..........|.|....|....:..:..:
Human   734 SFHALVCSRDDSALRKRTLSLTQRGRNKKGI-FSSLKGLDTLARKGKEKRPSITQVDELLHIYGS 797

  Fly  2704 TTASDPGSEAGDTSSGKYRFGPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSR-ATM 2767
            |....|...|              |..     :|..:.:|     :.|:.:.::.:.:... .|:
Human   798 TVDGVPRDNA--------------WEI-----QTYVHFQD-----NHGVTVGIKPEHRVEDILTL 838

  Fly  2768 AVS-RQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPF--------------------I 2811
            |.. ||.||..:       |:.|.|:     .:......|..|:                    :
Human   839 ACKMRQLEPSHY-------GLQLRKL-----VDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVYDV 891

  Fly  2812 VKTKIAKHLNIGESDKAERKAPESLPTRSLSQ--PNGLESYGMGRPDLEDSDSDSVASNEEAISF 2874
            ..||.....:.|.:..|:....:.|....:|.  |:|| :||.|.    ...::.:..|.||:|.
Human   892 QLTKTGSVCDFGFAVTAQVDERQHLSRIFISDVLPDGL-AYGEGL----RKGNEIMTLNGEAVSD 951

  Fly  2875 YPTTYAEVLYNFTAGGPQELGLERGMLIEILRKE-------VGPW----WFGRIKK------EET 2922
            ......|.|::           |:.:.:.::.:.       ...|    .|.|.:|      .::
Human   952 LDLKQMEALFS-----------EKSVGLTLIARPPDTKATLCTSWSDSDLFSRDQKSLLPPPNQS 1005

  Fly  2923 NLVEDILGPELGWFPK----EFVRI------IHCPETDNFF--IAHRAAADEA--AAEEATARAE 2973
            .|:|:.|..    |.|    :|..:      :...:||...  ::||...::.  :||:.||...
Human  1006 QLLEEFLDN----FKKNTANDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCR 1066

  Fly  2974 EGSVPVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDT 3038
                             :....|:|    .:|.|.....|....:|:........|..::||:||
Human  1067 -----------------SFNDSQAN----GMEGPRENQDPPPRSLARHLSDADRLRKVIQELVDT 1110

  Fly  3039 EVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIE-------- 3095
            |.:|||.|:.:.:.||..:... ...:.:.:..:|.::..:.:||:.|||.|..||.        
Human  1111 EKSYVKDLSCLFELYLEPLQNE-TFLTQDEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTL 1174

  Fly  3096 --QNQVAKVFLKMHKGFL-------CYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAE 3151
              .:|..|:...:...||       .||.:|..:.:....||.....|..:..|: .|.......
Human  1175 ETPSQFRKLLFSLGGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLD-ARNPTKQHS 1238

  Fly  3152 LPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELD-IPDS 3215
            ..|.::|:.||||:.:|||.|.|::....::..:..:.|:..|:..|...:    :.|:. |.:.
Human  1239 STLESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASH----INEMQKIYED 1299

  Fly  3216 QDTVNLALEAMRGITEAVNEGKRHSETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWN 3280
            ..||...|.|.:..||.........|.:.....|:.|   |.|.|..||..|::           
Human  1300 YGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWLN---PFLSLGKARKDLEL----------- 1350

  Fly  3281 SSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRV 3318
               |:|:|       ||.:|    .:||     :.|::
Human  1351 ---TVFVF-------KRAVI----LVYK-----ENCKL 1369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 SH3 2876..2942 CDD:214620 13/86 (15%)
RhoGEF 3028..3234 CDD:238091 55/223 (25%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 18/79 (23%)
TIAM2NP_036586.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 6/15 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..250 10/48 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..293 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..417 6/27 (22%)
PH1_Tiam1_2 505..631 CDD:269937 27/166 (16%)
Tiam_CC_Ex 645..742 CDD:408184 17/120 (14%)
Ubl1_cv_Nsp3_N-like 811..881 CDD:475130 14/86 (16%)
PDZ 887..976 CDD:214570 19/104 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1092 5/25 (20%)
RhoGEF 1103..1292 CDD:214619 46/194 (24%)
PH2_Tiam1_2 1294..1466 CDD:269957 25/109 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1500..1556
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1568..1628
Blue background indicates that the domain is not in the aligned region.

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