Protein Alignment RhoGEF3 and PLEKHG3

DIOPT Version :9

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: XP_011534929.1
• Gene: PLEKHG3 / 26030
• HGNCID: 20364
• Length: 1391
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 144/578 - (24%)
• Similarity: 229/578 - (39%)
• Gaps: 125/578 - (21%)

  Fly  2957 RAAADEAAAEEATARAEEGSV---PVPVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFV 3018
            |:|.:|.::.||.|:...||:   .:|            .::.::.:.:.::.|.:|.....  .
Human    54 RSAMEEPSSSEAPAKNGAGSLRSRHLP------------NSNNNSSSWLNVKGPLSPFNSRA--A 104

  Fly  3019 AQPDHSTI--IRRSAVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSIRLIFSNITAIYK 3081
            |.|.|..:  :.| .|||:::||..||:.|.:|.:.||..:.....:..|..:..:|.||..||.
Human   105 AGPAHHKLSYLGR-VVREIVETERMYVQDLRSIVEDYLLKIIDTPGLLKPEQVSALFGNIENIYA 168

  Fly  3082 FQRKFLEALRR-GIEQNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCRE 3145
            ...:.|..|.. ..:...||..|::..:.|..|:.|||.||.::..|....|.|......   |:
Human   169 LNSQLLRDLDSCNSDPVAVASCFVERSQEFDIYTQYCNNYPNSVAALTECMRDKQQAKFF---RD 230

  Fly  3146 SQNLAE--LPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVT 3208
            .|.|.:  |||.::||.|||||.:|.|.|.||.|                          ..|..
Human   231 RQELLQHSLPLGSYLLKPVQRILKYHLLLQEIAK--------------------------HFDEE 269

  Fly  3209 ELDIPDSQDTVNLALEAMRGITEAVNEGKR---HSETIARHQASFQNFKGPPLHLHSARFFLQVD 3270
            |    |..:.|..|::.|..:...:|:.||   |:..:...|:...|:|||.|..:..   |.::
Human   270 E----DGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTYGE---LVLE 327

  Fly  3271 ATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGRIFLDRCRVV-NVRDGKMFGHT-IKN 3333
            .|.:...:.|.. |.||||..|:..|:   :..||:|||.|......:: :.||...|..| .|:
Human   328 GTFRVHRVRNER-TFFLFDKTLLITKK---RGDHFVYKGNIPCSSLMLIESTRDSLCFTVTHYKH 388

  Fly  3334 SLRIYS------ESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEMTGFEYNYEERPGD 3392
            |.:.||      |.:..|.....|.....|.     |...|...:|  :.||..: |....|...
Human   389 SKQQYSIQAKTVEEKRNWTHHIKRLILENHH-----ATIPQKAKEA--ILEMDSY-YPNRYRCSP 445

  Fly  3393 YSDQSDYDAQDFELATGVTSG--ESSLPESPAKSTSRLCETLPKKSQSRDGISSAENSQIVTTTS 3455
            ...:..:.:|| |::|.|..|  :|....||               .||..:.|.:...::.:..
Human   446 ERLKKAWSSQD-EVSTNVRQGRRQSEPGHSP---------------YSRATLPSGQRGFVMPSLK 494

  Fly  3456 TGSLGRRHFGNWFRKPKSANCTPSQSPTHKPSFDADATLTE-ARVAAMELAEAAAALV 3512
                |||         ||           :|:......|.| ||.|.|:.|.:|..|:
Human   495 ----GRR---------KS-----------EPTKHLLRQLNEKARAAGMKHAGSAGTLL 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	57/206 (28%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	36/140 (26%)
		PH	<3285..3363	CDD:278594	24/85 (28%)
PLEKHG3	XP_011534929.1	RhoGEF	118..292	CDD:279015	57/206 (28%)
		PH_PLEKHG1_G2_G3	274..417	CDD:270063	40/149 (27%)
		PH	338..414	CDD:278594	24/79 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940