DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF3 and tiam-1

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_491367.3	Gene:	tiam-1 / 259373	WormBaseID:	WBGene00015704	Length:	889	Species:	Caenorhabditis elegans

Alignment Length:	765	Identity:	153/765 - (20%)
Similarity:	265/765 - (34%)	Gaps:	272/765 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2756 LEQDEQYSRATMAVSRQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHL 2820
            ||..|....|    |::|..:...|.|         :...:|.||.:..::.|..:::..|
Worm   250 LETSESSENA----SKEDIRQMLLLKN---------VVVTQRLNSLQQRALPGIELIQHDI---- 297

  Fly  2821 NIGESDKAERKAPES--LPTRSLSQPNGLESYGMGRPDLEDSDSDSVASNEEAIS---------- 2873
                |.:.::|..|.  ||:..|...| :.|:.:.|..:|..|.:::.|:..:.|
Worm   298 ----SPQIDQKLLEKCRLPSLFLYHFN-MNSFRIWRKPMETRDMNTMGSSMASTSQYHQIPIQIQ 357

  Fly  2874 -----------------FYP----TTYAEVLYNFTAGGPQELGLERG------MLIEILRKEVGP 2911
                             ::|    ||:.... .|....|.:..|..|      .|.|...:.
Worm   358 NQNPLPSQQIQPQQQQQYHPPDHVTTHNGTT-TFHTTNPTKPRLCEGSLAPGCSLAEASEQR--- 418

  Fly  2912 WWFGRIKKEETNLVEDILGPELGWFPKEFVRIIHCPETDNFFI------------AHRAAADEAA 2964
                  |:|.....:::.||.               ..:::|:            ||.
Worm   419 ------KREMAEQKKELAGPS---------------SAEDYFVRKTNGRLGLTIYAHN------- 455

  Fly  2965 AEEATARAEEGSVPVPVAAFAEDTDVTVTTDQSNVTLI--------------VI----ESPPTPS 3011
             ::...|||...|.......|:..|..|..|...::.:              ||    ::|.||.
Worm   456 -DDGVIRAEVRGVTSFAPRCAQVGDSVVAVDSELISSVRNASDVEKLLRIGKVIHLRRKTPLTPR 519

  Fly  3012 APSVDFVAQPDHSTIIRRS-------AVRELLDTEVNYVKLLAAICDGYLPAMSKRIDIFSPNSI 3069
            |||     |.|.:.:.:::       |::|||.||..||..|..:.:.:| .|.:..||.:. :|
Worm   520 APS-----QLDATNVNKKTGCAKLAMALQELLVTEKKYVSDLREMNEVFL-CMRQVRDIMNA-AI 577

  Fly  3070 RLIFSNITAIYKFQRKFLEALRRGI----EQN-----------QVAKVFLKMHKGFLCYSTYCNA 3119
            ||        ||.|..|::::...|    .|:           :|..||:.....|..|:.|...
Worm   578 RL--------YKMQTSFVDSIEEAIGDMSRQDISVAQIRDSVMRVCAVFINKCSDFKIYAEYAAG 634

  Fly  3120 YPRALIELETYDRVKDARTILENCRESQNLAELPLS--AHLLAPVQRICRYPLHLNEIIKSALEK 3182
            |  .|::.|    :|:.:.:|.......:..|...|  :.::.|||||.:|||.|.. |..||.|
Worm   635 Y--HLLQHE----IKNKKELLSKLEAVNSTREQHCSWESRMIKPVQRIVQYPLLLKN-IADALPK 692

  Fly  3183 GAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIARHQ 3247
            .|:|                             :..|..||:.|:...|.|||.:|..|..|::.
Worm   693 DARE-----------------------------RVQVEAALQKMQTSAEYVNEMQRLHEDYAQYM 728

  Fly  3248 ASFQNFKGPPLHLHSARFFLQVDATRQ----KQNLWNSS----YTLFLFDNQLV----YCKRDI- 3299
            .:.:....|.|    |...|::| ||:    ....|..:    |.:|:|.:.::    |.:::|
Worm   729 ETVRKANEPML----AEKSLRLD-TRELLVFAHIKWRDAPAEHYVVFVFHSLILLLPSYARKEIK 788

  Fly  3300 -----------------------IKRSHFIYKG-----------RIFLDRCRVVNVRDGKMFGHT 3330
                                   :|..|..::|           .::...|....::.     |.
Worm   789 MKWTRVLPINEVDINEMPNDALNLKLYHAAFEGPNGQLSHSNPNTVYNIECCQSQLKQ-----HL 848

  Fly  3331 IKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSEMT 3380
            |||    ..::|..:       :...||.||  ...:..||   ||||::
Worm   849 IKN----IKKARTLF-------SRESHRPLS--GSSQSDGG---YVSEVS 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620	13/75 (17%)
		RhoGEF	3031..3235	CDD:279015	56/220 (25%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	30/179 (17%)
		PH	<3285..3363	CDD:278594	17/116 (15%)
tiam-1	NP_491367.3	RhoGEF	541..715	CDD:238091	55/219 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930