Protein Alignment RhoGEF3 and scd1

DIOPT Version :9

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: NP_594221.1
• Gene: scd1 / 2542337
• PomBaseID: SPAC16E8.09
• Length: 872
• Species: Schizosaccharomyces pombe
• Alignment Length: 591
• Identity: 125/591 - (21%)
• Similarity: 220/591 - (37%)
• Gaps: 195/591 - (32%)

  Fly  2997 SNVTLIVIESPPTPSAPSVDFVAQPDHSTIIR--RSAVRELLDTEVNYVKLLAAICDGYLPAMSK 3059
            ||.|    :|..|||..:.|.|.....:::|.  |....||.:||:.|::.|..: ..|:..:.:
pombe   200 SNTT----KSSSTPSPSTDDNVPTGTLNSLIASGRRVTAELYETELKYIQDLEYL-SNYMVILQQ 259

  Fly  3060 RIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRG----IEQNQVAKVFLKMHKGFLCYSTYCNAY 3120
            : .|.|.::|..||:|:..|..|||:||..|...    :|:.::..:|:.:.:||..|..:|..:
pombe   260 K-QILSQDTILSIFTNLNEILDFQRRFLVGLEMNLSLPVEEQRLGALFIALEEGFSVYQVFCTNF 323

  Fly  3121 PRALIELETYDRVKDARTILENCRESQNLAEL-----PLSAHLLAPVQRICRYPLHLNEIIKSAL 3180
            |.|            .:.|::|..:...:|.|     .|.|.|:.|:||||:|||.||:::|
pombe   324 PNA------------QQLIIDNQNQLLKVANLLEPSYELPALLIKPIQRICKYPLLLNQLLK--- 373

  Fly  3181 EKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSETIAR 3245
                            |..:.|:.           ::.:...:..:..:...|||.:|
pombe   374 ----------------GTPSGYQY-----------EEELKQGMACVVRVANQVNETRR------- 404

  Fly  3246 HQASFQNFKGPPLHLHSAR-FFLQVDATRQKQNLWNSSYTLFLFDNQLVY-----CKRDIIKRSH 3304
                          :|..| ..::::   |:...| ..|:|..|...||:     ||.| |:|.:
pombe   405 --------------IHENRNAIIELE---QRVIDW-KGYSLQYFGQLLVWDVVNVCKAD-IEREY 450

  Fly  3305 FIYKGRIFLDRCRVVNVRDGKMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQF 3369
            .:|.....|..|:.::         |:|...|..             |.|:|.:.|.:|.|:
pombe   451 HVYLFEKILLCCKEMS---------TLKRQARSI-------------SMNKKTKRLDSLQLK--- 490

  Fly  3370 GGKALYVSEMTGFEYNYEERPGDYSDQSDY--DAQDFELATGVTSGES----------------- 3415
             |:.| .|.:|....|:  ..|.|:.|..:  |.|.......:.:.||
pombe   491 -GRIL-TSNITTVVPNH--HMGSYAIQIFWRGDPQHESFILKLRNEESHKLWMSVLNRLLWKNEH 551

  Fly  3416 ----------SLPESPAKSTSRLCETLPKKSQSRDGISSAE---------NSQIVTTTSTGSLGR 3461
                      |.|.:|..:.|        .||:..|.:|::         :..:.:.||..|
pombe   552 GSPKDIRSAASTPANPVYNRS--------SSQTSKGYNSSDYDLLRTHSLDENVNSPTSISS--- 605

  Fly  3462 RHFGNWFRKPKSANCTPSQSPTHKPSFDADATLTEAR--------------VAAMELAEAAAALV 3512
                      .|:..:|....|.|.:  ..||.|:.|              .:::..::..:.:|
pombe   606 ----------PSSKSSPFTKTTSKDT--KSATTTDERPSDFIRLNSEESVGTSSLRTSQTTSTIV 658

  Fly  3513 PTDSSS 3518
            ..||||
pombe   659 SNDSSS 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	49/212 (23%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	27/138 (20%)
		PH	<3285..3363	CDD:278594	19/82 (23%)
scd1	NP_594221.1	CDC24	105..194	CDD:283938
		RhoGEF	232..401	CDD:279015	49/212 (23%)
		PH_Scd1	404..546	CDD:270066	39/196 (20%)
		PB1	775..848	CDD:214770

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840