DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and DNMBP

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:NP_056036.1 Gene:DNMBP / 23268 HGNCID:30373 Length:1577 Species:Homo sapiens


Alignment Length:1226 Identity:235/1226 - (19%)
Similarity:401/1226 - (32%) Gaps:403/1226 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  2329 PQSYGTRLCDHELTYEMLRKSPIMNFRRGDSGDYELPVMLRNRETINSG----------GNSELN 2383
            |.:||..|    ..::.|..:.:         |:|:...:|...|:..|          |.....
Human   244 PGTYGVAL----YRFQALEPNEL---------DFEVGDKIRILATLEDGWLEGSLKGRTGIFPYR 295

  Fly  2384 F--MSNETRIYEHPTTVLKSQRSLRQSPGSRDDLNLEVAVGVGGDYIYRQPANQPRSSSVKAEFL 2446
            |  :..:||:.|  |..|..:.||.:.|.:..|. ||..:||        ...:..:|..:||..
Human   296 FVKLCPDTRVEE--TMALPQEGSLARIPETSLDC-LENTLGV--------EEQRHETSDHEAEEP 349

  Fly  2447 TTATTKSCTKTLD--TCDYWPRCAACQHKSVSGELKKGPSASGKPLTVLDNVQPHVTSVIVNEDN 2509
            ....:::.|..|.  |.:|.....:.|.:..:|...:.|....:.....|:.....|.|:    |
Human   350 DCIISEAPTSPLGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEVV----N 410

  Fly  2510 AVPGPQLRSLEKSNPSWTFLCSGIASICQPVQQTETDHST---AQEAAEEDIVIRKVKPNKSRRT 2571
            .:         .|.|...|         .|..|....:||   :...:|:       .|:.....
Human   411 GI---------SSQPQVPF---------HPNLQKSQYYSTVGGSHPHSEQ-------YPDLLPLE 450

  Fly  2572 GRSRSLPSVMLRRLYLAGMPKPGSNEMGTTSDCAASLSQQIKAVSSPTLSEPCLEEQPQKGTEST 2636
            .|:|...|:..:|:|                       .|:|.:..|.|  |...          
Human   451 ARTRDYASLPPKRMY-----------------------SQLKTLQKPVL--PLYR---------- 480

  Fly  2637 DVANTGSSAGSGGLGVLQKFKRTLNNFNNKNQLHISPLSPAAVGNNAPKTKTSPTTTTASIAPMI 2701
                 |||..:         .|.:....:..|||          |.|..||...|::..||:..:
Human   481 -----GSSVSA---------SRVVKPRQSSPQLH----------NLASYTKKHHTSSVYSISERL 521

  Fly  2702 TTTTASDPGSEAGDTSSGKYRFGPLIWRSSKERRKTKYNRRDKCNSGDSGIQIELEQDEQYSRAT 2766
                ...||.:|..          |:..::..            :.||....::.:..:|.    
Human   522 ----EMKPGPQAQG----------LVMEAATH------------SQGDGSTDLDSKLTQQL---- 556

  Fly  2767 MAVSRQDEPRAFALTNGSCGVALSKMRAIRRTNSAKASSILGPFIVKTKIAKHLNI----GESD- 2826
                                :...|             |:.||.....||.:|.:|    .|.| 
Human   557 --------------------IEFEK-------------SLAGPGTEPDKILRHFSIMDFNSEKDI 588

  Fly  2827 -----------------KAERKAPESLPTRSLSQPNGLESYGMG-------RPDLEDSDSDSVAS 2867
                             ||.|..|....|...:.|:.|....:.       ||........|...
Human   589 VRGSSKLITEQELPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQ 653

  Fly  2868 NEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVEDILGPE 2932
            ...|:|                 |:.|...| ...|.|.|| ||...|| ..::|:..       
Human   654 RTNAVS-----------------PKLLSRHR-PTCETLEKE-GPGHMGR-SLDQTSPC------- 691

  Fly  2933 LGWFPKEFVRIIHCPETDNFFIAHRAAADE-----AAAEEATARAE--------EGSVPVPVAAF 2984
                |...|||   .|.:.....:..|.:|     ...::.::|||        |.::.......
Human   692 ----PLVLVRI---EEMERDLDMYSRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESLNMEL 749

  Fly  2985 AEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQ-PDHSTIIRRS-AVRELLDTEVNYVKLLA 3047
            .:..::|:.:.||: :|:         |||....|: |:...:.:|: .:.|||.||.:|::.|.
Human   750 QQLREMTLLSSQSS-SLV---------APSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLE 804

  Fly  3048 AICDGYL-PAMSKRIDIFSPN-SIRLIFSNITAIYKFQRKFLEALRRGIEQNQVAKVFLKMHKGF 3110
            ...:..: |....::    || ....:|.|:..:.|..::.|.||.   ..:.|..|||. |:..
Human   805 MCIERIMVPMQQAQV----PNIDFEGLFGNMQMVIKVSKQLLAALE---ISDAVGPVFLG-HRDE 861

  Fly  3111 L--CYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLAELP-------------LSAHLLA 3160
            |  .|..||..:..|:..||.|::.:..:..|::     :||:|.             |.:.|:.
Human   862 LEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD-----SLADLKSLYNEWGCTNYINLGSFLIK 921

  Fly  3161 PVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEA 3225
            ||||:.||||.|.|::.|..|..                             ||.....|..| |
Human   922 PVQRVMRYPLLLMELLNSTPESH-----------------------------PDKVPLTNAVL-A 956

  Fly  3226 MRGITEAVNEGKRHSETIARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYT-LFLFD 3289
            ::.|...:||.||..:.:.:::      ||....|......|.:.:..:|.|..:|... |..|.
Human   957 VKEINVNINEYKRRKDLVLKYR------KGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFA 1015

  Fly  3290 NQLVYCKRDIIKRSHFIYKGRIFLDRCRVVN--VRDGKMFGHTIKNSLRIYSESRDKWYDFSFRS 3352
            .|:   |.::.:.:.     :.|..:.|::.  :||..::...|:.|..:...:....:|.....
Human  1016 PQI---KDEVFEETE-----KNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMER 1072

  Fly  3353 ANRK-------HRFLS----TLALERQFGGKALYVSEM-------TG--------FE-----YNY 3386
            .:|.       ||::|    |...||.   :.|.:|.:       ||        |:     ||.
Human  1073 GHRDLEQFERVHRYISDQLFTNFKERT---ERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNC 1134

  Fly  3387 EERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAKSTSRLCETLPKKSQSRDGI 3442
            .||.....|:...:    ||.:...:.|:        ..::|.:.|||..|...|:
Human  1135 TERAEKLKDKKTLE----ELQSARNNYEA--------LNAQLLDELPKFHQYAQGL 1178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620 13/65 (20%)
RhoGEF 3031..3235 CDD:279015 53/220 (24%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 25/146 (17%)
PH <3285..3363 CDD:278594 15/90 (17%)
DNMBPNP_056036.1 SH3_DNMBP_N1 6..56 CDD:212728
SH3_DNMBP_N2 70..123 CDD:212729
SH3_DNMBP_N3 149..199 CDD:212730
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..244 235/1226 (19%)
SH3_DNMBP_N4 247..296 CDD:212731 10/61 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..395 10/59 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 591..624 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..659 4/19 (21%)
RhoGEF 788..966 CDD:279015 53/220 (24%)
BAR_DNMBP 1017..1208 CDD:153273 35/185 (19%)
SH3_DNMBP_C1 1289..1345 CDD:212732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1348..1487
SH3_DNMBP_C2 1517..1573 CDD:213017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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