DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGEF3 and ARHGEF9

DIOPT Version :9

Sequence 1:NP_612024.4 Gene:RhoGEF3 / 38050 FlyBaseID:FBgn0264707 Length:3519 Species:Drosophila melanogaster
Sequence 2:NP_001340852.1 Gene:ARHGEF9 / 23229 HGNCID:14561 Length:529 Species:Homo sapiens


Alignment Length:612 Identity:162/612 - (26%)
Similarity:259/612 - (42%) Gaps:145/612 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  2862 SDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVE 2926
            |.|:.:.:..:|      ||.:::......:||..:.|.:|::|......||:|:|..||     
Human    14 SRSLITGDSIVS------AEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEE----- 67

  Fly  2927 DILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVT 2991
                   ||||..|||:              ....|...||..:..:.|.:              
Human    68 -------GWFPASFVRL--------------WVNQEDEVEEGPSDVQNGHL-------------- 97

  Fly  2992 VTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPA 3056
                ..|...:.:..|          :...|.   :|.:.:.|::.||.:|:|.|..||:|||..
Human    98 ----DPNSDCLCLGRP----------LQNRDQ---MRANVINEIMSTERHYIKHLKDICEGYLKQ 145

  Fly  3057 MSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQ-----NQVAKVFLKMHKGFLCYSTY 3116
            ..||.|:||...:::||.||..||:||..|:..|.:....     :::...||:...||..||.|
Human   146 CRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEY 210

  Fly  3117 CNAYPRALIELETYDRVKDAR--TILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSA 3179
            ||.:..|.:||...  :||:|  ...|.||..|.:.::.:...||.|||:||:|||.|.|::|  
Human   211 CNNHLDACMELSKL--MKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLK-- 271

  Fly  3180 LEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSET-- 3242
                          .:|...:||..              |..||..||.:|:.:||.||..|.  
Human   272 --------------YTAQDHSDYRY--------------VAAALAVMRNVTQQINERKRRLENID 308

  Fly  3243 -IARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLW-------NSSYTLFLFDNQLVYCKRDI 3299
             ||:.|||..:::|..:...|:......:..      |       |.....||||:|:|.||:|:
Human   309 KIAQWQASVLDWEGEDILDRSSELIYTGEMA------WIYQPYGRNQQRVFFLFDHQMVLCKKDL 367

  Fly  3300 IKRSHFIYKGRIFLDRCRVVNVRDGK--MFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLST 3362
            |:|....|||||.:|:..||::.||:  .|..::||:.:::::..::.:.|..:....|.|:|..
Human   368 IRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRA 432

  Fly  3363 LALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAK---- 3423
            ...||    |.:...|..|||.:..::     .|:....:......||.|..|..|..|..    
Human   433 FREER----KMVQEDEKIGFEISENQK-----RQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPL 488

  Fly  3424 -----------STSRLCE-TLPKKSQS 3438
                       :.|::.| |.||:|||
Human   489 NHGQYLVPDGIAQSQVFEFTEPKRSQS 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGEF3NP_612024.4 DUF4802 <754..>790 CDD:292678
SH3 2876..2942 CDD:214620 18/65 (28%)
RhoGEF 3031..3235 CDD:279015 67/210 (32%)
PH_Collybistin_ASEF 3240..3373 CDD:269931 40/144 (28%)
PH <3285..3363 CDD:278594 28/79 (35%)
ARHGEF9NP_001340852.1 SH3_ARHGEF9 20..81 CDD:212908 21/92 (23%)
RhoGEF 120..299 CDD:214619 67/210 (32%)
PH_Collybistin_ASEF 304..443 CDD:269931 41/148 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 116 1.000 Domainoid score I5956
eggNOG 1 0.900 - - E1_KOG3519
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001415
OrthoInspector 1 1.000 - - otm40937
orthoMCL 1 0.900 - - OOG6_103254
Panther 1 1.100 - - O PTHR45834
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 1 1.000 - - X1124
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.840

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