Protein Alignment RhoGEF3 and ARHGEF9

DIOPT Version :10

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: NP_001340852.1
• Gene: ARHGEF9 / 23229
• HGNCID: 14561
• Length: 529
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 162/612 - (26%)
• Similarity: 259/612 - (42%)
• Gaps: 145/612 - (23%)

  Fly  2862 SDSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVE 2926
            |.|:.:.:..:|      ||.:::......:||..:.|.:|::|......||:|:|..||
Human    14 SRSLITGDSIVS------AEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEE----- 67

  Fly  2927 DILGPELGWFPKEFVRIIHCPETDNFFIAHRAAADEAAAEEATARAEEGSVPVPVAAFAEDTDVT 2991
                   ||||..|||:              ....|...||..:..:.|.:
Human    68 -------GWFPASFVRL--------------WVNQEDEVEEGPSDVQNGHL-------------- 97

  Fly  2992 VTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPA 3056
                ..|...:.:..|          :...|.   :|.:.:.|::.||.:|:|.|..||:|||..
Human    98 ----DPNSDCLCLGRP----------LQNRDQ---MRANVINEIMSTERHYIKHLKDICEGYLKQ 145

  Fly  3057 MSKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQ-----NQVAKVFLKMHKGFLCYSTY 3116
            ..||.|:||...:::||.||..||:||..|:..|.:....     :::...||:...||..||.|
Human   146 CRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEY 210

  Fly  3117 CNAYPRALIELETYDRVKDAR--TILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSA 3179
            ||.:..|.:||...  :||:|  ...|.||..|.:.::.:...||.|||:||:|||.|.|::|
Human   211 CNNHLDACMELSKL--MKDSRYQHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLK-- 271

  Fly  3180 LEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSET-- 3242
                          .:|...:||..              |..||..||.:|:.:||.||..|.
Human   272 --------------YTAQDHSDYRY--------------VAAALAVMRNVTQQINERKRRLENID 308

  Fly  3243 -IARHQASFQNFKGPPLHLHSARFFLQVDATRQKQNLW-------NSSYTLFLFDNQLVYCKRDI 3299
             ||:.|||..:::|..:...|:......:..      |       |.....||||:|:|.||:|:
Human   309 KIAQWQASVLDWEGEDILDRSSELIYTGEMA------WIYQPYGRNQQRVFFLFDHQMVLCKKDL 367

  Fly  3300 IKRSHFIYKGRIFLDRCRVVNVRDGK--MFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLST 3362
            |:|....|||||.:|:..||::.||:  .|..::||:.:::::..::.:.|..:....|.|:|..
Human   368 IRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRA 432

  Fly  3363 LALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFELATGVTSGESSLPESPAK---- 3423
            ...||    |.:...|..|||.:..::     .|:....:......||.|..|..|..|..
Human   433 FREER----KMVQEDEKIGFEISENQK-----RQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPL 488

  Fly  3424 -----------STSRLCE-TLPKKSQS 3438
                       :.|::.| |.||:|||
Human   489 NHGQYLVPDGIAQSQVFEFTEPKRSQS 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	SH3	2876..2942	CDD:214620	18/65 (28%)
		RhoGEF	3028..3234	CDD:238091	68/212 (32%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	40/144 (28%)
ARHGEF9	NP_001340852.1	SH3_ARHGEF9	20..81	CDD:212908	21/92 (23%)
		RhoGEF	120..299	CDD:214619	67/210 (32%)
		PH_Collybistin_ASEF	304..443	CDD:269931	41/148 (28%)