DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF3 and Vav1

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_035821.3	Gene:	Vav1 / 22324	MGIID:	98923	Length:	845	Species:	Mus musculus

Alignment Length:	436	Identity:	100/436 - (22%)
Similarity:	168/436 - (38%)	Gaps:	110/436 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  2995 DQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRR-SAVRELLDTEVNYVKLLAAICDGYLPAMS 3058
            |:....|:.:||.|||          |..:...:| ..:||:..||..|...|.:|...::..:.
Mouse   171 DEIYEDLMRLESVPTP----------PKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQ 225

  Fly  3059 KRIDIFSPNSIRLIFSNITAIYKFQRKFLEALR---RGIEQNQVAKVFLKMHKGFLCYSTYCNAY 3120
            :   ...|..:..||.||..::.....||:.|:   .|.....:.:||:|..:.||.|..||:..
Mouse   226 R---FLKPQDMETIFVNIEELFSVHTHFLKELKDALAGPGATTLYQVFIKYKERFLVYGRYCSQV 287

  Fly  3121 PRALIELETYDRV----KDARTILENCRESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALE 3181
            ..|...|   |:|    :|.:..||.|.:..|.....|...|:.|:||:.:|.|.|.|::|
Mouse   288 ESASKHL---DQVATAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVK---- 345

  Fly  3182 KGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHSET---I 3243
                                 ...|.||      ::.:.|||:|||.:.:.|||.||.:||   |
Mouse   346 ---------------------HTQDATE------KENLRLALDAMRDLAQCVNEVKRDNETLRQI 383

  Fly  3244 ARHQASFQNFK------GPPLHLHSARFFLQVDATRQKQNLWNSSYT---LFLFDNQLVYCKRDI 3299
            ...|.|.:|..      |.|          ::|...:..::...|.|   .||.|..|:.|||
Mouse   384 TNFQLSIENLDQSLANYGRP----------KIDGELKITSVERRSKTDRYAFLLDKALLICKR-- 436

  Fly  3300 IKRSHFIYKGRIFLDRCRV----VNVRDGKMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFL 3360
             :...:..|..:.|...:|    ...||.|.:.|    ...:..:...:.|:..|::...|.:::
Mouse   437 -RGDSYDLKASVNLHSFQVRDDSSGERDNKKWSH----MFLLIEDQGAQGYELFFKTRELKKKWM 496

  Fly  3361 STLALERQFGGKALYVSEMTGFEYNYEERPGDYSDQSDYDAQDFEL 3406
                  .||   .:.:|.:             |.:.:..:..||::
Mouse   497 ------EQF---EMAISNI-------------YPENATANGHDFQM 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	53/210 (25%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	30/148 (20%)
		PH	<3285..3363	CDD:278594	17/81 (21%)
Vav1	NP_035821.3	CH	18..102	CDD:320720
		RhoGEF	195..371	CDD:238091	53/212 (25%)
		PH_Vav	385..508	CDD:269930	28/161 (17%)
		C1_1	516..567	CDD:278556	2/5 (40%)
		SH3_VAV1_1	596..658	CDD:212912
		SH2_Vav1	665..767	CDD:198268
		SH3_VAV1_2	786..839	CDD:212909
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940