DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF3 and Plekhg1

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	XP_006512502.1	Gene:	Plekhg1 / 213783	MGIID:	2676551	Length:	1487	Species:	Mus musculus

Alignment Length:	519	Identity:	131/519 - (25%)
Similarity:	200/519 - (38%)	Gaps:	131/519 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  2995 DQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAM-- 3057
            |.|.......:|..:|....||.|             |:|:|:||..||:.|.:|.:|||..:
Mouse   190 DTSGTPQTTADSATSPKLLYVDRV-------------VQEILETERTYVQDLKSIVEGYLECIRD 241

  Fly  3058 SKRIDIFSPNSIRLIFSNITAIYKFQRKFLEALRRGIEQNQV--AKVFLKMHKGFLCYSTYCNAY 3120
            ..::.:.:.:...| |.||..||.|..:.|:.| ...|.:.|  |:.|:...:.|..|:.||..|
Mouse   242 QTKLPLVTEDRAAL-FGNIQDIYHFNSELLQDL-ENCENDPVAIAECFVSKSEEFHIYTQYCTNY 304

  Fly  3121 PRALIELETYDRVKDARTILENCRESQNLA--ELPLSAHLLAPVQRICRYPLHLNEIIKSALEKG 3183
            ||::..|....|.|   .:.:..||.|...  .|||.::||.|||||.:|.|.|:| |::.|:|
Mouse   305 PRSVAVLTECMRNK---ILTKFFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHE-IENHLDK- 364

  Fly  3184 AKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKR---HSETIAR 3245
            |.||.|                  ..||          |::.|:.:...:|:.||   |:..:..
Mouse   365 ATEGYD------------------VVLD----------AIDTMQRVAWHINDMKRKHEHAVRLQE 401

  Fly  3246 HQASFQNFKGPPLHLHSARFFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRDIIKRSHFIYKGR 3310
            .|:...|::||.|..:..   |.::.|.:.|.. ....||||.|..|:..|:   :...|.||..
Mouse   402 IQSLLTNWEGPDLTSYGE---LVLEGTFRIQKA-KKERTLFLLDQLLLITKK---RDDTFTYKAH 459

  Fly  3311 IFLDRCRVVNV-------------RDGKMFGHTIKNSLRIYSESRDK--WYDFSFRSANRKHRFL 3360
            |......:|.|             ::.|: .||::     ....:||  |.      .:.|...|
Mouse   460 ILCGNLMLVEVIPKEPLSFSVFHYKNPKL-QHTVQ-----AKSQQDKRLWV------LHLKRLIL 512

  Fly  3361 STLALERQFGGKALY-VSEMTGFEYNYEERPG-DYSDQSDYDAQDFELATGVTSG-----ESSLP 3418
            ...|...:...||.. :.||....|     || .||.:.       |:.|...|.     ..|.|
Mouse   513 ENHAAAAKIPAKAKQAILEMDAIHY-----PGFCYSPEG-------EMKTPCGSAPHRLRRKSEP 565

  Fly  3419 ESPAKSTSRLCETLPKKSQSRDGISSAEN-SQIVTTTSTGSLGRRHFGNWFRKPKSANCTPSQS 3481
            .|.:....:..||    ||....:|..|: ||:.:..                |...||.|..:
Mouse   566 SSRSHKVLKTSET----SQDIQKVSREESPSQLTSAV----------------PAQRNCQPGSA 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	63/209 (30%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	30/147 (20%)
		PH	<3285..3363	CDD:278594	20/92 (22%)
Plekhg1	XP_006512502.1	RhoGEF	211..387	CDD:238091	65/223 (29%)
Plekhg1	XP_006512502.1	PH_PLEKHG1_G2_G3	369..514	CDD:270063	38/191 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940