DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGEF3 and uig-1

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_001256489.1	Gene:	uig-1 / 179808	WormBaseID:	WBGene00009337	Length:	972	Species:	Caenorhabditis elegans

Alignment Length:	944	Identity:	183/944 - (19%)
Similarity:	330/944 - (34%)	Gaps:	313/944 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2739 YNRRDKCNSGDSGIQIELEQDEQYSRATMA--VSRQDEPRAFALTNGSCGVALSKMRAIRRT--N 2799
            |.:||:          |.|.|.:.:::.::  :.|...|...:|       |||:...|..|  |
Worm    37 YRQRDR----------EHEVDPRMTQSMISERIQRSQSPVDVSL-------ALSEDSTITITELN 84

  Fly  2800 SAKASSILGPFIVKTKIAKHLNIGESDKAERKAPESLPTRSLSQPNGL--ESYGMGRPDLEDSDS 2862
            :...|:.....|..|.:.:                    |..||.:|:  .:|.:    |:.::|
Worm    85 NRNGSTFNANSINATPVMR--------------------RRRSQMSGVRQRNYRI----LDQNES 125

  Fly  2863 DSVASNEEAISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEETNLVED 2927
            ..:...:.|.:.                 :|   ::|.|:.              :|....|:|.
Worm   126 KYILQQQSAAAI-----------------EE---KKGTLLR--------------RKSSKKLIEP 156

  Fly  2928 ---ILGPELGWFPKEFVRIIHCPETDNFFIAHR----------AAADEAAAEEATARAEEGSVPV 2979
               |:.|.:.....:...:.:..::..:.::.|          :...:.:.||.|||....|...
Worm   157 LPMIITPPVLMARTQCCAVCYKEKSTGYSVSSRTQSYPLEAMSSVTTDRSTEEETARLSFVSSST 221

  Fly  2980 PVAAFAEDTDVTVTTDQSNVTLIVIESPPTPSAPSVDFVAQPDHSTIIRRSAVR----------- 3033
            ..::.......:...|:||..    .:....||.|..|......|.  ||||:.
Worm   222 GYSSARSSLRSSDGGDESNNN----SAGNRDSAISNTFSLSSQSSA--RRSALLTKGSLTHLDRI 280

  Fly  3034 --ELLDTEVNYVKLLAAICDGYLPAM---SKRIDIFSPNSIRLIFSNITAIYKFQRKFLEAL-RR 3092
              ||||||..||:.|.|:..||:..:   .:::.: :.::|..:|..|..|:.|.::....| ..
Worm   281 AIELLDTERTYVEDLNAVIKGYMDFLVEDREKLKV-TLDAISSLFGCIERIFAFNKQLYNQLDAA 344

  Fly  3093 GIEQNQVAKVFLKMHKGFLCYSTYCNAYPRALIELETYDRVKDARTILENCRESQNLA---ELPL 3154
            .::..::::.|::....|..|..||..|.|.:..|....:    :.::....:.:.||   .|.|
Worm   345 DLDCVKMSRCFVESSGKFEDYIEYCTNYHRMMSTLYHLQQ----QPLVARALQERQLALNHSLQL 405

  Fly  3155 SAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTDYEQLDVTELDIPDSQDTV 3219
            ||:||.|||||.:|.|.|..|:                 |:...||..|:|           ..|
Worm   406 SAYLLKPVQRILKYHLFLENIL-----------------KNMPSTTHPEEL-----------IQV 442

  Fly  3220 NLALEAMRGITEAVNEGKR---HSETIARHQASFQNFKGPPLHLH--SARFFLQVDAT-RQKQNL 3278
            ..|.|.|......:|:.|:   |.|.:.:.|::.|.:|...:.:.  ||...|.::|| ||..:
Worm   443 KRAHEVMTSQAARINDEKKKAEHIERVGQLQSTLQKWKADEIQISNLSAYGDLLLEATFRQAGS- 506

  Fly  3279 WNSSYTLFLFDNQLV--------YCKRDII--------------------------KRSHFIYKG 3309
             .::..||||:..|:        |..:|.|                          .|:.:::..
Worm   507 -KTTRLLFLFEEMLLIVKQRGANYVCKDYIMCSNLMLNEWICPEEPLSFQVLSFDNPRAQYVFMA 570

  Fly  3310 --------------RIFLDRCRV----------VNVRDGKM--FGH------TIKNSLRI--YSE 3340
                          |:.||...|          :::.:.::  ||.      ::||..::  |.|
Worm   571 SSMEQKRTWMQELKRMMLDHYSVEIPEKTKQLMLSIDNTRIVPFGRPEFAEVSMKNHKKVPKYLE 635

  Fly  3341 SRDKWYDFSFRSANRKHRFLSTLALERQFGGKALYVSE-----------MTGFEYN--------- 3385
            .|.|..|....|..|:     :|:..|..||....:||           |.|..||
Worm   636 KRRKSVDAKEESNRRR-----SLSASRLLGGSKTSISEPIKEEQKCTCHMNGGIYNGANPTTSKS 695

  Fly  3386 --------YEERPGDYSDQSDY---------DAQDFEL-ATGVTSGESSLPESPAKSTSRLCETL 3432
                    |::.....|...:|         .|...:| ...:|.     |.|.|..:||
Worm   696 IISHPSLTYQQSHPTQSTDPNYCRPPVCRTQSAATIDLNQVHITE-----PNSAAVMSSR----- 750

  Fly  3433 PKKSQSRDGISSAENSQIVTTTSTGSLGRRH--------------FGNWFRKPKSANCTP---SQ 3480
            .:..|:|:......::|...:||:..:|...              ||:..:...::|.:.   |:
Worm   751 SRYQQARNRRLPPRHNQESRSTSSRRMGEEEIDRTFDQLYEELVSFGDSTKPTVTSNRSQRLRSE 815

  Fly  3481 SPTHKPSFDADATLTEARVAA------MELAEAA 3508
            :|        .:|:|...|||      :.:||.|
Worm   816 AP--------QSTVTTITVAATPATATLSIAECA 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620	8/68 (12%)
		RhoGEF	3031..3235	CDD:279015	53/223 (24%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	39/203 (19%)
		PH	<3285..3363	CDD:278594	24/145 (17%)
uig-1	NP_001256489.1	RhoGEF	280..458	CDD:214619	52/210 (25%)
uig-1	NP_001256489.1	PH_PLEKHG1_G2_G3	439..590	CDD:270063	30/163 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940