DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF3 and prx-13

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	NP_495513.1	Gene:	prx-13 / 174192	WormBaseID:	WBGene00004198	Length:	330	Species:	Caenorhabditis elegans

Alignment Length:	87	Identity:	26/87 - (29%)
Similarity:	37/87 - (42%)	Gaps:	10/87 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  2862 SDSVASNEE----AISFYPTTYAEVLYNFTAGGPQELGLERGMLIEILRKEVGPWWFGRIKKEET 2922
            |..|.:.||    |....|...|:.|::|.|...|||....|..:.:..||..|    |::....
Worm   218 SQMVQAAEEKRKWATGAAPHYTAQALFDFQASNEQELSFMNGETLRVAPKEEQP----RVRGWLL 278

  Fly  2923 NLVEDILGPELGWFPKEFVRII 2944
            ..|.|  |..:|..|..:|||:
Worm   279 ASVAD--GSRIGLVPINYVRIV 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620	18/65 (28%)
		RhoGEF	3031..3235	CDD:279015
		PH_Collybistin_ASEF	3240..3373	CDD:269931
		PH	<3285..3363	CDD:278594
prx-13	NP_495513.1	Peroxin-13_N	70..217	CDD:282008
prx-13	NP_495513.1	SH3_PEX13_eumet	239..297	CDD:212798	18/63 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030