Protein Alignment RhoGEF3 and Prex2

DIOPT Version :10

• Sequence 1: NP_612024.4
• Gene: RhoGEF3 / 38050
• FlyBaseID: FBgn0264707
• Length: 3519
• Species: Drosophila melanogaster
• Sequence 2: XP_006495504.1
• Gene: Prex2 / 109294
• MGIID: 1923385
• Length: 1617
• Species: Mus musculus
• Alignment Length: 295
• Identity: 63/295 - (21%)
• Similarity: 96/295 - (32%)
• Gaps: 99/295 - (33%)

  Fly    63 FTIINSCDQTIWPAITPGENFNGGGFELKPGQSIVFHAPVGWSGRIWGRTGCKFDSTG-TGTCET 126
            :.|.:|| .||..|:.....|..|..|.||.    |.                 :||| |.....
Mouse    37 YQIFDSC-YTISKAMESSLVFLTGQEEFKPN----FR-----------------NSTGSTLAAMV 79

  Fly   127 GSCGSTLKCSASGKPPASLAEFTLAALDFYDVS--LVDGFNLP--MSVTPMNGKGNCSVAGCVAD 187
            |:.||:|..:||    ..|..:.:..:.:....  |.|.|..|  :.|.|.:            .
Mouse    80 GAGGSSLSVAAS----RILGLYYMPQVGYTSSCSILSDKFQFPSYLRVVPSD------------K 128

  Fly   188 LRPHCPQELAVKSNGKVISCRSACDVFDRDEYCCRGVYGNPVVCQPTYYSKI--------FKQAC 244
            ::......| :|..|.|.....|.|    |:|   |.||     ..|:..|:        |.:..
Mouse   129 IQSEAMVNL-IKHFGWVWVGAVAAD----DDY---GKYG-----VKTFKEKMESANLCVAFSETI 180

  Fly   245 PTAYS--------YAYDDPTS-IMTCTASDYVIS---------------FCSSRFVLFTFLTTSH 285
            |..||        .|..:.|: ::....||..:|               :.:|...:.:.|....
Mouse   181 PKVYSNEKMQKAINAVKNSTAKVIVLYTSDIDLSPFVLELIHHNVTDRTWIASEAWITSALIAKP 245

  Fly   286 DYFNYDSNQVSFILDH-------DFYIYMIYFIHP 313
            :||.|....:.|.|..       :|    :|.|||
Mouse   246 EYFPYFGGSIGFALPRTTIPGLKEF----LYDIHP 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	SH3	2876..2942	CDD:214620
		RhoGEF	3028..3234	CDD:238091
		PH_Collybistin_ASEF	3240..3373	CDD:269931
Prex2	XP_006495504.1	RhoGEF	19..204	CDD:459876	48/217 (22%)
		PH_Collybistin_ASEF	210..356	CDD:269931	14/71 (20%)
		DEP_1_P-Rex	374..454	CDD:239886
		DEP_2_P-Rex	466..558	CDD:239887
		PDZ_canonical	587..>636	CDD:483948
		PDZ_RGS12-like	668..743	CDD:467194