DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGEF3 and Prex2

DIOPT Version :9

Sequence 1:	NP_612024.4	Gene:	RhoGEF3 / 38050	FlyBaseID:	FBgn0264707	Length:	3519	Species:	Drosophila melanogaster
Sequence 2:	XP_006495504.1	Gene:	Prex2 / 109294	MGIID:	1923385	Length:	1617	Species:	Mus musculus

Alignment Length:	383	Identity:	97/383 - (25%)
Similarity:	175/383 - (45%)	Gaps:	75/383 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  3022 DHSTIIRRSAVRELLDTEVNYVKLLAAICDGYLPAMSK----RID-IFSPNSIRLIFSNITAIYK 3081
            |....:|...:.||..||.:||..|..:...:|..|::    ::| ..:..:::::||||..|..
Mouse    10 DKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAAAKVDKNVTEETVKMLFSNIEEILI 74

  Fly  3082 FQRKFLEALRRGI-----EQNQVAKVFLKMHKGFLCYSTYCNAYPRA---LIELETYDRVKDART 3138
            ..::||:.:...:     .|.:|...||.....|..|..||:.:.:|   |:||   ::::..||
Mouse    75 VHKEFLKVVEECLYPEPSAQQEVGACFLHFKDKFRIYDEYCSNHEKAQKLLLEL---NKIRTIRT 136

  Fly  3139 ILENCR--ESQNLAELPLSAHLLAPVQRICRYPLHLNEIIKSALEKGAKEGNDTDGAKSAGKTTD 3201
            .|.||.  ..:...::||..:|:.|:||||:|||.|.|::|                ::..:.:|
Mouse   137 FLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLLLKELLK----------------RTPRRHSD 185

  Fly  3202 YEQLDVTELDIPDSQDTVNLALEAMRGITEAVNEGKRHS---ETIARHQASFQNFKGPPL----- 3258
            |              ..|..||:||:.:...:||.||..   |.:...||..:.::|..:
Mouse   186 Y--------------TAVMEALQAMKAVCSNINEAKRQMEKLEVLEEWQAHIEGWEGSNITDTCT 236

  Fly  3259 HLHSARFFLQVDATRQKQNLWNSSYTLFLFDNQLVYCKRD--IIKRS-------HFIYKGRIFLD 3314
            .:......:::.:...::.::      |||||.||||||.  .:|.|       .::::|||..:
Mouse   237 EMLMCGVLMKISSGNIQERVF------FLFDNLLVYCKRKHRRLKNSKASTDGYRYVFRGRINTE 295

  Fly  3315 RCRVVNVRDG----KMFGHTIKNSLRIYSESRDKWYDFSFRSANRKHRFLSTLALERQ 3368
            ...|.||.||    ...||.:.|..:|::.:::||:....:|...||.:...:..||:
Mouse   296 VMEVENVDDGTADFHSSGHIVVNGWKIHNTAKNKWFVCMAKSPEEKHEWFEAILKERE 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGEF3	NP_612024.4	DUF4802	<754..>790	CDD:292678
		SH3	2876..2942	CDD:214620
		RhoGEF	3031..3235	CDD:279015	55/218 (25%)
		PH_Collybistin_ASEF	3240..3373	CDD:269931	36/150 (24%)
		PH	<3285..3363	CDD:278594	30/90 (33%)
Prex2	XP_006495504.1	RhoGEF	19..204	CDD:366202	55/217 (25%)
		PH_Collybistin_ASEF	210..356	CDD:269931	36/150 (24%)
		DEP_1_P-Rex	374..454	CDD:239886
		DEP_2_P-Rex	466..558	CDD:239887
		PDZ_signaling	587..662	CDD:238492
		PDZ_signaling	669..736	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3519
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43009
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810